Gene Expression Literature Summary

• Symbol: Ctnna2
• Name: catenin alpha 2
• ID: MGI:88275

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)			2	2	1	1	1	8	1	5	1	6	1	7	2	2	5	1	4	1	8
In situ RNA (section)								2				7				1	1		1		1
Immunohistochemistry (whole mount)	1	1	1	2	1
Northern blot																					1
Western blot				1			1	4		2		2		2	1	2			1		10
RT-PCR		1						1		1		2		1		1			2	1	3
cDNA clones											1	1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ctnna2  catenin alpha 2   (Synonyms: alpha N-catenin, alpha(N)-catenin, Catna, Catna2, chp)
Results	Reference
3*	J:105375 Ajioka I, Maeda T, Nakajima K, Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development. Eur J Neurosci. 2006 Jan;23(2):296-308
4	J:102941 Ajioka I, Nakajima K, Switching of alpha-catenin from alphaE-catenin in the cortical ventricular zone to alphaN-catenin II in the intermediate zone. Brain Res Dev Brain Res. 2005 Nov 7;160(1):106-11
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:105284 Birger Y, Davis J, Furusawa T, Rand E, Piatigorsky J, Bustin M, A role for chromosomal protein HMGN1 in corneal maturation. Differentiation. 2006 Feb;74(1):19-29
1*	J:277278 Butali A, Mossey PA, Adeyemo WL, Eshete MA, Gowans LJJ, Busch TD, Jain D, Yu W, Huan L, Laurie CA, Laurie CC, Nelson S, Li M, Sanchez-Lara PA, Magee WP, Magee KS, Auslander A, Brindopke F, Kay DM, Caggana M, Romitti PA, Mills JL, Audu R, Onwuamah C, Oseni GO, Owais A, James O, Olaitan PB, Aregbesola BS, Braimah RO, Oginni FO, Oladele AO, Bello SA, Rhodes J, Shiang R, Donkor P, Obiri-Yeboah S, Arthur FKN, Twumasi P, Agbenorku P, Plange-Rhule G, Oti AA, Ogunlewe OM, Oladega AA, Adekunle AA, Erinoso AO, Adamson OO, Elufowoju AA, Ayelomi OI, Hailu T, Hailu A, Demissie Y, Derebew M, Eliason S, Romero-Bustillous M, Lo C, Park J, Desai S, Mohammed M, Abate F, Abdur-Rahman LO, Anand D, Saadi I, Oladugba AV, Lachke SA, Amendt BA, Rotimi CN, Marazita ML, Cornell RA, Murray JC, Adeyemo AA, Genomic analyses in African populations identify novel risk loci for cleft palate. Hum Mol Genet. 2019 Mar 15;28(6):1038-1051
1*	J:302571 Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N, Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020 Dec 16;13(1):167
1	J:85505 Cattelino A, Liebner S, Gallini R, Zanetti A, Balconi G, Corsi A, Bianco P, Wolburg H, Moore R, Oreda B, Kemler R, Dejana E, The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol. 2003 Sep 15;162(6):1111-22
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:320718 Duethorn B, Groll F, Rieger B, Drexler HCA, Brinkmann H, Kremer L, Stehling M, Borowski MT, Mildner K, Zeuschner D, Zernicka-Goetz M, Stemmler MP, Busch KB, Vaquerizas JM, Bedzhov I, Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism. Nat Commun. 2022 Feb 1;13(1):610
5	J:202007 Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, A Kukuruzinska M, The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. Lab Invest. 2013 Nov;93(11):1203-18
2	J:238422 Fumoto K, Takigawa-Imamura H, Sumiyama K, Kaneiwa T, Kikuchi A, Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition. Development. 2017 Jan 01;144(1):151-162
1	J:83398 Hollnagel A, Grund C, Franke WW, Arnold HH, The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol Cell Biol. 2002 Jul;22(13):4760-70
1*	J:296375 Holmes G, Gonzalez-Reiche AS, Lu N, Zhou X, Rivera J, Kriti D, Sebra R, Williams AA, Donovan MJ, Potter SS, Pinto D, Zhang B, van Bakel H, Jabs EW, Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Cell Rep. 2020 Jul 7;32(1):107871
1	J:304850 Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernandez-Baldovinos J, Zhou L, Hoss C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Grone HJ, Graumann PL, Niessen CM, Offermanns S, Wickstrom SA, Worzfeld T, Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun. 2021 Feb 26;12(1):1308
2	J:255472 Jimenez-Caliani AJ, Pillich R, Yang W, Diaferia GR, Meda P, Crisa L, Cirulli V, alphaE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation. Cell Rep. 2017 Aug 8;20(6):1295-1306
3	J:134436 Kadowaki M, Nakamura S, Machon O, Krauss S, Radice GL, Takeichi M, N-cadherin mediates cortical organization in the mouse brain. Dev Biol. 2007 Apr 1;304(1):22-33
3	J:147274 Karpowicz P, Willaime-Morawek S, Balenci L, DeVeale B, Inoue T, van der Kooy D, E-Cadherin regulates neural stem cell self-renewal. J Neurosci. 2009 Mar 25;29(12):3885-96
4	J:236651 Katsunuma S, Honda H, Shinoda T, Ishimoto Y, Miyata T, Kiyonari H, Abe T, Nibu K, Takai Y, Togashi H, Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium. J Cell Biol. 2016 Feb 29;212(5):561-75
1	J:277726 Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C, Epidermal development requires ninein for spindle orientation and cortical microtubule organization. Life Sci Alliance. 2019 Apr;2(2)
1	J:185949 Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB, Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
4	J:106707 Lien WH, Klezovitch O, Fernandez TE, Delrow J, Vasioukhin V, alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science. 2006 Mar 17;311(5767):1609-12
3	J:139820 Lien WH, Klezovitch O, Null M, Vasioukhin V, alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain. J Cell Sci. 2008 May 1;121(Pt 9):1357-62
3*	J:114661 Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF, Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol. 2006 Nov;26(21):7929-41
7	J:258447 Maddala R, Rao PV, Switching of alpha-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation. Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3445-3455
1	J:326946 Martin JB, Herman K, Houssin NS, Rich W, Reilly MA, Plageman TF Jr, Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts. Front Cell Dev Biol. 2022;10:840129
1*	J:194034 Mazahery AR, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis GD, Behringer RR, Yamada G, Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41
1	J:291493 Najas S, Pijuan I, Esteve-Codina A, Usieto S, Martinez JD, Zwijsen A, Arbones ML, Marti E, Le Dreau G, A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex. Development. 2020 Jul 13;147(13):dev187005
1	J:330740 Narayanan R, Pham L, Kerimoglu C, Watanabe T, Castro Hernandez R, Sokpor G, Ulmke PA, Kiszka KA, Tonchev AB, Rosenbusch J, Seong RH, Teichmann U, Frahm J, Fischer A, Bonn S, Stoykova A, Staiger JF, Tuoc T, Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. iScience. 2018 Jun 29;4:109-126
7	J:77488 Park C, Falls W, Finger JH, Longo-Guess CM, Ackerman SL, Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation. Nat Genet. 2002 Jul;31(3):279-84
1*	J:29443 Qiu M, Bulfone A, Martinez S, Meneses JJ, Shimamura K, Pedersen RA, Rubenstein JL, Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 1995 Oct 15;9(20):2523-38
1	J:201523 Ray S, Foote HP, Lechler T, beta-Catenin protects the epidermis from mechanical stresses. J Cell Biol. 2013 Jul 8;202(1):45-52
2*	J:31212 Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL, Longitudinal organization of the anterior neural plate and neural tube. Development. 1995 Dec;121(12):3923-33
3	J:19633 Shimamura K, Hirano S, McMahon AP, Takeichi M, Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development. 1994 Aug;120(8):2225-34
2	J:313618 Sokpor G, Kerimoglu C, Nguyen H, Pham L, Rosenbusch J, Wagener R, Nguyen HP, Fischer A, Staiger JF, Tuoc T, Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner. Front Mol Neurosci. 2021;14:687581
9	J:106946 Stocker AM, Chenn A, Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex. Brain Res. 2006 Feb 16;1073-1074:151-8
1	J:176963 Sumigray KD, Chen H, Lechler T, Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. J Cell Biol. 2011 Aug 22;194(4):631-42
1	J:324244 Sun J, Ha N, Liu Z, Bian Q, Wang X, A Neural Crest-specific Overexpression Mouse Model Reveals the Transcriptional Regulatory Effects of Dlx2 During Maxillary Process Development. Front Physiol. 2022;13:855959
1	J:80255 Tudela C, Formoso MA, Martinez T, Perez R, Aparicio M, Maestro C, Del Rio A, Martinez E, Ferguson M, Martinez-Alvarez C, TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion. Int J Dev Biol. 2002 May;46(3):333-6
2	J:97223 Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM, E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005 Mar 23;24(6):1146-56
17*	J:18004 Uchida N, Shimamura K, Miyatani S, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M, Mouse alpha N-catenin: two isoforms, specific expression in the nervous system, and chromosomal localization of the gene. Dev Biol. 1994 May;163(1):75-85
6*	J:111612 Uemura M, Takeichi M, alphaN-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain. Dev Dyn. 2006 May 11;235(9):2559-2566
1	J:73084 Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E, Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001 Dec;3(12):1076-85
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4	J:204591 Yamben IF, Rachel RA, Shatadal S, Copeland NG, Jenkins NA, Warming S, Griep AE, Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
3	J:163165 Yano M, Hayakawa-Yano Y, Mele A, Darnell RB, Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling. Neuron. 2010 Jun 24;66(6):848-58