Gene Expression Literature Summary

• Symbol: Atp1a3
• Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
• ID: MGI:88107

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E2	E2.5	E3	E4	E9.5	E10.5	E12.5	E14.5	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)										1		1		1	1	1	4
In situ RNA (section)						1	1		2	1	1				1	1	2
Immunohistochemistry (whole mount)				1	1
In situ reporter (knock in)																	1
Northern blot															1
Western blot				1	1								1	1	3		7
RT-PCR	1	1	1	1	1			1							1		4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Atp1a3  ATPase, Na+/K+ transporting, alpha 3 polypeptide   (Synonyms: Atpa-2, MGC:27631, MGC:38713, MGC:38914, MGC:39036)
Results	Reference
2	J:99702 Albert Y, Whitehead J, Eldredge L, Carter J, Gao X, Tourtellotte WG, Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis. J Cell Biol. 2005 Apr 25;169(2):257-68
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:259556 Bottger P, Glerup S, Gesslein B, Illarionova NB, Isaksen TJ, Heuck A, Clausen BH, Fuchtbauer EM, Gramsbergen JB, Gunnarson E, Aperia A, Lauritzen M, Lambertsen KL, Nissen P, Lykke-Hartmann K, Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. Sci Rep. 2016 Feb 25;6:22047
2*	J:151948 Clapcote SJ, Duffy S, Xie G, Kirshenbaum G, Bechard AR, Rodacker Schack V, Petersen J, Sinai L, Saab BJ, Lerch JP, Minassian BA, Ackerley CA, Sled JG, Cortez MA, Henderson JT, Vilsen B, Roder JC, Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14085-90
1	J:108845 Erichsen S, Berger S, Schmid W, Stierna P, Hultcrantz M, Na,K-ATPase expression in the mouse cochlea is not dependent on the mineralocorticoid receptor. Hear Res. 2001 Oct;160(1-2):37-46
5*	J:18442 Herrera VL, Cova T, Sassoon D, Ruiz-Opazo N, Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression. Am J Physiol. 1994 May;266(5 Pt 1):C1301-12
2*	J:151007 Hilgenberg LG, Pham B, Ortega M, Walid S, Kemmerly T, O'Dowd DK, Smith MA, Agrin Regulation of {alpha}3 Sodium-Potassium ATPase Activity Modulates Cardiac Myocyte Contraction. J Biol Chem. 2009 Jun 19;284(25):16956-65
2	J:316199 Ikeda K, Onimaru H, Kawakami K, Knockout of sodium pump alpha3 subunit gene (Atp1a3(-/-)) results in perinatal seizure and defective respiratory rhythm generation. Brain Res. 2017 Jul 1;1666:27-37
4	J:210870 Ikeda K, Satake S, Onaka T, Sugimoto H, Takeda N, Imoto K, Kawakami K, Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice. J Physiol. 2013 Jul 1;591(Pt 13):3433-49
1	J:237402 Iwai-Takekoshi L, Ramos A, Schaler A, Weinreb S, Blazeski R, Mason C, Retinal pigment epithelial integrity is compromised in the developing albino mouse retina. J Comp Neurol. 2016 Dec 15;524(18):3696-3716
1	J:314906 Khang R, Jo A, Kang H, Kim H, Kwag E, Lee JY, Koo O, Park J, Kim HK, Jo DG, Hwang I, Ahn JY, Lee Y, Choi JY, Lee YS, Shin JH, Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci Rep. 2021 Nov 23;11(1):22745
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:307518 Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, Casari G, Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet. 2011 Jun;7(6):e1002129
1	J:284759 Li Q, Cui S, Ma Q, Liu Y, Yu H, Geng G, Agborbesong E, Ren C, Wei K, Zhang Y, Yang J, Bai X, Cai G, Xie Y, Li X, Chen X, Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. JCI Insight. 2019 Sep 19;4(18)
1	J:242127 Liu Z, Li W, Ma X, Ding N, Spallotta F, Southon E, Tessarollo L, Gaetano C, Mukouyama YS, Thiele CJ, Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development. J Biol Chem. 2014 Oct 24;289(43):29801-16
11*	J:62912 MacPhee DJ, Jones DH, Barr KJ, Betts DH, Watson AJ, Kidder GM, Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse. Dev Biol. 2000 Jun 15;222(2):486-98
1	J:81899 Moseley AE, Lieske SP, Wetzel RK, James PF, He S, Shelly DA, Paul RJ, Boivin GP, Witte DP, Ramirez JM, Sweadner KJ, Lingrel JB, The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice. J Biol Chem. 2003 Feb 14;278(7):5317-24
3	J:117414 Moseley AE, Williams MT, Schaefer TL, Bohanan CS, Neumann JC, Behbehani MM, Vorhees CV, Lingrel JB, Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J Neurosci. 2007 Jan 17;27(3):616-26
2*	J:98210 Radzyukevich TL, Moseley AE, Shelly DA, Redden GA, Behbehani MM, Lingrel JB, Paul RJ, Heiny JA, The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm. Am J Physiol Cell Physiol. 2004 Nov;287(5):C1300-10
1	J:164650 Shiina N, Yamaguchi K, Tokunaga M, RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks. J Neurosci. 2010 Sep 22;30(38):12816-30
2	J:330184 Tuomainen T, Naumenko N, Mutikainen M, Shakirzyanova A, Sczelecki S, Estall JL, Ruas JL, Tavi P, PGC-1alpha4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes. Cells. 2022 Sep 20;11(19)
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120