Gene Expression Literature Summary

• Symbol: Mir449a
• Name: microRNA 449a
• ID: MGI:3619407

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E9.5	E10	E10.5	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E19.5	P
In situ RNA (section)							1	3	1	1	4	1	2	1	1
In situ RNA (whole mount)					1	1	2	1
Northern blot									1			1		1		1	2
RT-PCR	1	1	1	1						1			1				6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mir449a  microRNA 449a   (Synonyms: mir 449, Mirn449a, mmu-mir-449a)
Results	Reference
1	J:304721 Chang SH, Su YC, Chang M, Chen JA, MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs. Elife. 2021 Mar 31;10:e63768
4	J:133461 Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, McManus M, Harfe B, Giraldez AJ, Horvitz RH, Schier AF, Dulac C, Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 2008 Jan 10;57(1):41-55
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:238636 Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA, Gerlich DW, MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 2016 Nov 15;35(22):2386-2398
3*	J:162481 Hoesel B, Bhujabal Z, Przemeck GK, Kurz-Drexler A, Weisenhorn DM, Angelis MH, Beckers J, Combination of in silico and insitu hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis. Gene Expr Patterns. 2010 Sep;10(6):265-73
2*	J:305376 Li B, Wang Z, Yang F, Huang J, Hu X, Deng S, Tian M, Si X, miR449a5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation. Mol Med Rep. 2021 Jan;23(1)
12*	J:147805 Redshaw N, Wheeler G, Hajihosseini MK, Dalmay T, microRNA-449 is a putative regulator of choroid plexus development and function. Brain Res. 2009 Jan 23;1250:20-6
3	J:275368 Shu P, Wu C, Liu W, Ruan X, Liu C, Hou L, Zeng Y, Fu H, Wang M, Chen P, Zhang X, Yin B, Yuan J, Qiang B, Peng X, The spatiotemporal expression pattern of microRNAs in the developing mouse nervous system. J Biol Chem. 2019 Mar 8;294(10):3444-3453
5	J:119483 Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA, Maternal microRNAs are essential for mouse zygotic development. Genes Dev. 2007 Mar 15;21(6):644-8
2	J:302983 Wildung M, Esser TU, Grausam KB, Wiedwald C, Volceanov-Hahn L, Riedel D, Beuermann S, Li L, Zylla J, Guenther AK, Wienken M, Ercetin E, Han Z, Bremmer F, Shomroni O, Andreas S, Zhao H, Lize M, Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis. Cell Death Differ. 2019 Dec;26(12):2740-2757
2	J:326951 Wildung M, Herr C, Riedel D, Wiedwald C, Moiseenko A, Ramirez F, Tasena H, Heimerl M, Alevra M, Movsisyan N, Schuldt M, Volceanov-Hahn L, Provoost S, Nothe-Menchen T, Urrego D, Freytag B, Wallmeier J, Beisswenger C, Bals R, van den Berge M, Timens W, Hiemstra PS, Brandsma CA, Maes T, Andreas S, Heijink IH, Pardo LA, Lize M, miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly. Int J Mol Sci. 2022 Jul 13;23(14)
1	J:212272 Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C, Yan W, Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7