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Gene Expression Literature Summary
Symbol
Name
ID
Chd7
chromodomain helicase DNA binding protein 7
MGI:2444748

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E7.5 E8.5 E9 E9.5 E10 E10.5 E11.5 E12.5 E13.5 E14.5 E15.5 E16.5 E18.5 A
In situ protein (section) 2 2 1 4 2 2 1
In situ RNA (section) 1 1 4 1 1
In situ RNA (whole mount) 1 1 3 2 1
In situ reporter (knock in) 2 2 2 2 2 4 3 1 3
Western blot 1 1 1
RT-PCR 1 3 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Chd7  chromodomain helicase DNA binding protein 7   (Synonyms: A730019I05Rik, Cycn, Cyn, Dz, Edy, Flo, GENA 47, Gena 52, GENA 60, Lda, Mt, Obt, Todo, WBE1, Whi)
Results  Reference
3J:161880 Bergman JE, Bosman EA, van Ravenswaaij-Arts CM, Steel KP, Study of smell and reproductive organs in a mouse model for CHARGE syndrome. Eur J Hum Genet. 2010 Feb;18(2):171-7
5J:104123 Bosman EA, Penn AC, Ambrose JC, Kettleborough R, Stemple DL, Steel KP, Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. Hum Mol Genet. 2005 Nov 15;14(22):3463-76
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:187550 Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van Ijcken W, Dekkers DH, Demmers J, Rijkers EJ, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA, Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet. 2011 Jun;43(6):607-11
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
4J:119812 Hurd EA, Capers PL, Blauwkamp MN, Adams ME, Raphael Y, Poucher HK, Martin DM, Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm Genome. 2007 Feb;18(2):94-104
2J:188806 Hurd EA, Micucci JA, Reamer EN, Martin DM, Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 2012 Sep;129(9-12):308-23
5J:164582 Hurd EA, Poucher HK, Cheng K, Raphael Y, Martin DM, The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
4J:187010 Jiang X, Zhou Y, Xian L, Chen W, Wu H, Gao X, The mutation in chd7 causes misexpression of bmp4 and developmental defects in telencephalic midline. Am J Pathol. 2012 Aug;181(2):626-41
2J:174086 Layman WS, Hurd EA, Martin DM, Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Hum Mol Genet. 2011 Aug 15;20(16):3138-50
2J:148116 Layman WS, McEwen DP, Beyer LA, Lalani SR, Fernbach SD, Oh E, Swaroop A, Hegg CC, Raphael Y, Martens JR, Martin DM, Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome. Hum Mol Genet. 2009 Jun 1;18(11):1909-23
1J:193698 Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP, Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1738-43
11J:207089 Liu Y, Harmelink C, Peng Y, Chen Y, Wang Q, Jiao K, CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice. Hum Mol Genet. 2014 Apr 15;23(8):2145-56
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
11J:154590 Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ, Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest. 2009 Nov;119(11):3301-10
2*J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1J:188772 Voss AK, Vanyai HK, Collin C, Dixon MP, McLennan TJ, Sheikh BN, Scambler P, Thomas T, MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012 Sep 11;23(3):652-63
1*J:100636 Wang KS, Zahn LE, Favor J, Huang KM, Stambolian D, Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. Mamm Genome. 2005 May;16(5):332-43
1J:163172 Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei C, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC, CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet. 2010 Sep 15;19(18):3491-501

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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory