Gene Expression Literature Summary

• Symbol: Tardbp
• Name: TAR DNA binding protein
• ID: MGI:2387629

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2.5	E3	E3.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E18	E18.5	E	P
Immunohistochemistry (section)	1	1	1	1	2	1			1			1										9
In situ RNA (section)									1	1		1	1	1		1	1					1
Immunohistochemistry (whole mount)		1	1		1
In situ RNA (whole mount)						1	1	1	1	1	1						1
In situ reporter (knock in)								1	1			1										2
Northern blot																						1
Western blot							1		2			3			1			1	1	1	2	6
RT-PCR	1	2		1	1									1							2	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tardbp  TAR DNA binding protein   (Synonyms: 1190002A23Rik, Tdp43, TDP-43)
Results	Reference
1	J:235148 Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J, Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R, Olson EN, Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
1*	J:282177 Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T, Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice. Front Mol Neurosci. 2019;12:231
4	J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
5	J:265666 Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chio A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, Acevedo-Arozena A, Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J. 2018 Jun 1;37(11)
3	J:312418 Gagne M, Deshaies JE, Sidibe H, Benchaar Y, Arbour D, Dubinski A, Litt G, Peyrard S, Robitaille R, Sephton CF, Vande Velde C, hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated. Front Neurosci. 2021;15:724307
2*	J:284994 Gasperini L, Rossi A, Cornella N, Peroni D, Zuccotti P, Potrich V, Quattrone A, Macchi P, The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. Mol Biol Cell. 2018 Oct 24;:mbcE18020108
3	J:346070 Godoy-Corchuelo JM, Ali Z, Brito Armas JM, Martins-Bach AB, Garcia-Toledo I, Fernandez-Beltran LC, Lopez-Carbonero JI, Bascunana P, Spring S, Jimenez-Coca I, Munoz de Bustillo Alfaro RA, Sanchez-Barrena MJ, Nair RR, Nieman BJ, Lerch JP, Miller KL, Ozdinler HP, Fisher EMC, Cunningham TJ, Acevedo-Arozena A, Corrochano S, TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43. Neurobiol Dis. 2024 Feb 15;193:106437
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:324271 Kao TJ, Wang CY, Hsu TI, Wu YH, Chuang JY, Huang CC, Hsieh CT, TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb. Neurosci Res. 2022 Mar;176:31-39
1	J:298381 Koppers M, Blokhuis AM, Westeneng HJ, Terpstra ML, Zundel CA, Vieira de Sa R, Schellevis RD, Waite AJ, Blake DJ, Veldink JH, van den Berg LH, Pasterkamp RJ, C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits. Ann Neurol. 2015 Sep;78(3):426-38
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
4*	J:158641 Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD, Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathol. 2010 Apr;119(4):409-19
2	J:308816 Lin LT, Razzaq A, Di Gregorio SE, Hong S, Charles B, Lopes MH, Beraldo F, Prado VF, Prado MAM, Duennwald ML, Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity. FASEB J. 2021 May;35(5):e21594
4*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
1	J:282431 Minis A, Rodriguez JA, Levin A, Liu K, Govek EE, Hatten ME, Steller H, The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24639-24650
5	J:338266 Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W, Li L, Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation. Nat Commun. 2023 Jul 17;14(1):4275
16*	J:159888 Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P rd, Herz J, Yu G, TDP-43 is a developmentally regulated protein essential for early embryonic development. J Biol Chem. 2010 Feb 26;285(9):6826-34
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1*	J:326556 Wang Y, Yasmin L, Li L, Gao P, Xu X, Sun X, Godbout R, DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Nat Commun. 2022 Jul 1;13(1):3794
8*	J:155958 Wu LS, Cheng WC, Hou SC, Yan YT, Jiang ST, Shen CK, TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis. 2010 Jan;48(1):56-62
1	J:311882 Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J, TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018 Sep 6;174(6):1477-1491.e19
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48