Gene Expression Literature Summary

• Symbol: Sorcs2
• Name: sortilin-related VPS10 domain containing receptor 2
• ID: MGI:1932289

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E20	P
Immunohistochemistry (section)	1	1	1		1	2				3			2		1	1	4
In situ RNA (section)	1	2	2	1	1		1	3			1	1		2	2		3
Immunohistochemistry (whole mount)									1	1					1		1
Northern blot																	1
Western blot																	2
RT-PCR																	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sorcs2  sortilin-related VPS10 domain containing receptor 2   (Synonyms: mKIAA1329, VPS10 domain receptor protein)
Results	Reference
4*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
4	J:262532 Boggild S, Molgaard S, Glerup S, Nyengaard JR, Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment. J Comp Neurol. 2018 Jun 1;526(8):1267-1286
3	J:309393 Boggild S, Molgaard S, Glerup S, Nyengaard JR, Spatiotemporal patterns of sortilin and SorCS2 localization during organ development. BMC Cell Biol. 2016 Mar 10;17:8
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
6*	J:242313 Forge A, Taylor RR, Dawson SJ, Lovett M, Jagger DJ, Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017 Mar;13(3):e1006692
4	J:214739 Glerup S, Olsen D, Vaegter CB, Gustafsen C, Sjoegaard SS, Hermey G, Kjolby M, Molgaard S, Ulrichsen M, Boggild S, Skeldal S, Fjorback AN, Nyengaard JR, Jacobsen J, Bender D, Bjarkam CR, Sorensen ES, Fuchtbauer EM, Eichele G, Madsen P, Willnow TE, Petersen CM, Nykjaer A, SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
3*	J:217851 Oetjen S, Mahlke C, Hermans-Borgmeyer I, Hermey G, Spatiotemporal expression analysis of the growth factor receptor SorCS3. J Comp Neurol. 2014 Oct 15;522(15):3386-402
8*	J:67268 Rezgaoui M, Hermey G, Riedel IB, Hampe W, Schaller HC, Hermans-Borgmeyer I, Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain. Mech Dev. 2001 Feb;100(2):335-8
2	J:190893 Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, Hempstead BL, ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. J Exp Med. 2012 Nov 19;209(12):2291-305
1	J:86868 Simon R, Lufkin T, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
10	J:342618 Thomasen PB, Salasova A, Kjaer-Sorensen K, Woloszczukova L, Lavicky J, Login H, Tranberg-Jensen J, Almeida S, Beel S, Kavkova M, Qvist P, Kjolby M, Ovesen PL, Nolte S, Vestergaard B, Udrea AC, Nejsum LN, Chao MV, Van Damme P, Krivanek J, Dasen J, Oxvig C, Nykjaer A, SorCS2 binds progranulin to regulate motor neuron development. Cell Rep. 2023 Oct 26;42(11):113333