Gene Expression Literature Summary

• Symbol: Sv2a
• Name: synaptic vesicle glycoprotein 2a
• ID: MGI:1927139

48 matching records from 48 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E20	E	P
Immunohistochemistry (section)	1		1	1	3	1	1	2	1	1	1	1	5	6	1	1	23
In situ RNA (section)						2						1					1
Immunohistochemistry (whole mount)											1		2	2		1	6
Western blot			2		1		2				1		4				7
RT-PCR		1									1						3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sv2a  synaptic vesicle glycoprotein 2a
Results	Reference
6*	J:36947 Ahnert-Hilger G, Kutay U, Chahoud I, Rapoport T, Wiedenmann B, Synaptobrevin is essential for secretion but not for the development of synaptic processes. Eur J Cell Biol. 1996 May;70(1):1-11
1	J:161300 An MC, Lin W, Yang J, Dominguez B, Padgett D, Sugiura Y, Aryal P, Gould TW, Oppenheim RW, Hester ME, Kaspar BK, Ko CP, Lee KF, Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7
1	J:111100 Apel ED, Glass DJ, Moscoso LM, Yancopoulos GD, Sanes JR, Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold. Neuron. 1997 Apr;18(4):623-35
1	J:195554 Audouard E, Schakman O, Rene F, Huettl RE, Huber AB, Loeffler JP, Gailly P, Clotman F, The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. PLoS One. 2012;7(12):e50509
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:260635 Bowerman M, Salsac C, Bernard V, Soulard C, Dionne A, Coque E, Benlefki S, Hince P, Dion PA, Butler-Browne G, Camu W, Bouchard JP, Delpire E, Rouleau GA, Raoul C, Scamps F, KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects. Neurobiol Dis. 2017 Oct;106:35-48
1*	J:64996 Burgess RW, Skarnes WC, Sanes JR, Agrin isoforms with distinct amino termini. Differential expression, localization, and function. J Cell Biol. 2000 Oct 2;151(1):41-52
1	J:211808 Carpanini SM, McKie L, Thomson D, Wright AK, Gordon SL, Roche SL, Handley MT, Morrison H, Brownstein D, Wishart TM, Cousin MA, Gillingwater TH, Aligianis IA, Jackson IJ, A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton. Dis Model Mech. 2014 Jun;7(6):711-22
1	J:241784 Chaverra M, George L, Mergy M, Waller H, Kujawa K, Murnion C, Sharples E, Thorne J, Podgajny N, Grindeland A, Ueki Y, Eiger S, Cusick C, Babcock AM, Carlson GA, Lefcort F, The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system. Dis Model Mech. 2017 May 01;10(5):605-618
1	J:168230 Chen J, Billings SE, Nishimune H, Calcium channels link the muscle-derived synapse organizer laminin beta2 to bassoon and CAST/Erc2 to organize presynaptic active zones. J Neurosci. 2011 Jan 12;31(2):512-25
1*	J:124331 Cho JH, Lepine M, Andrews W, Parnavelas J, Cloutier JF, Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. J Neurosci. 2007 Aug 22;27(34):9094-104
7*	J:200912 Crevecoeur J, Foerch P, Doupagne M, Thielen C, Vandenplas C, Moonen G, Deprez M, Rogister B, Expression of SV2 isoforms during rodent brain development. BMC Neurosci. 2013;14(1):87
2*	J:299228 De Pace R, Britt DJ, Mercurio J, Foster AM, Djavaherian L, Hoffmann V, Abebe D, Bonifacino JS, Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons. Cell Rep. 2020 Jun 16;31(11):107775
2	J:336102 Eenjes E, Benthem F, Boerema-de Munck A, Buscop-van Kempen M, Tibboel D, Rottier RJ, Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells. Cell Mol Life Sci. 2023 Mar 3;80(3):79
2	J:250440 Ferguson R, Serafeimidou-Pouliou E, Subramanian V, Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation. J Anat. 2016 Dec;229(6):871-891
1	J:312418 Gagne M, Deshaies JE, Sidibe H, Benchaar Y, Arbour D, Dubinski A, Litt G, Peyrard S, Robitaille R, Sephton CF, Vande Velde C, hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated. Front Neurosci. 2021;15:724307
1	J:316205 Garcia-Garcia E, Chaparro-Cabanillas N, Coll-Manzano A, Carreras-Caballe M, Giralt A, Del Toro D, Alberch J, Masana M, Rodriguez MJ, Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain. Int J Mol Sci. 2021 Dec 1;22(23)
1	J:33098 Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR, Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
1	J:240526 Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P, PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Am J Hum Genet. 2017 May 4;100(5):706-724
2*	J:216140 Hanson MG, Fregoso VL, Vrana JD, Tucker CL, Niswander LA, Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95
1	J:80082 Herbst R, Avetisova E, Burden SJ, Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development. 2002 Dec;129(23):5449-60
1	J:298381 Koppers M, Blokhuis AM, Westeneng HJ, Terpstra ML, Zundel CA, Vieira de Sa R, Schellevis RD, Waite AJ, Blake DJ, Veldink JH, van den Berg LH, Pasterkamp RJ, C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits. Ann Neurol. 2015 Sep;78(3):426-38
1	J:225578 Krishnaswamy A, Yamagata M, Duan X, Hong YK, Sanes JR, Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015 Aug 27;524(7566):466-70
1	J:338838 Leboeuf M, Vargas-Abonce SE, Peze-Hedsieck E, Dupont E, Jimenez-Alonso L, Moya KL, Prochiantz A, ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal alpha-motoneurons. EMBO Rep. 2023 Aug 3;24(8):e56525
1	J:330733 Letchuman S, Tucker A, Miranda D, Adkins RL, Aceves M, Dietz V, Jagrit V, Leonards A, Lee YI, Dulin JN, Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord. eNeuro. 2022 Nov-Dec;9(6):ENEURO.0214-22.2022
1	J:74184 Liang SX, Motin L, Moussa CE, Lavidis NA, Phillips WD, Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas deferens. Synapse. 2001 Oct;42(1):1-11
1*	J:159572 Medrihan L, Rohlmann A, Fairless R, Andrae J, Doring M, Missler M, Zhang W, Kilimann MW, Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol. 2009 Nov 1;587(Pt 21):5095-106
8	J:91066 Misgeld T, Burgess RW, Lewis RM, Cunningham JM, Lichtman JW, Sanes JR, Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron. 2002 Nov 14;36(4):635-48
1	J:296800 Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T, Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. Cell Rep. 2019 Dec 24;29(13):4362-4376.e6
5*	J:56117 Noakes PG, Chin D, Kim SS, Liang S, Phillips WD, Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. J Comp Neurol. 1999 Aug 9;410(4):531-40
3	J:125253 Pan J, Luk C, Kent G, Cutz E, Yeger H, Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol. 2006 Sep;35(3):320-6
1	J:198564 Prince JE, Brignall AC, Cutforth T, Shen K, Cloutier JF, Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Development. 2013 Jun;140(11):2398-408
2	J:44100 Rich KA, Zhan Y, Blanks JC, Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. J Comp Neurol. 1997 Nov 10;388(1):47-63
1	J:251846 Ross JA, Webster RG, Lechertier T, Reynolds LE, Turmaine M, Bencze M, Jamshidi Y, Cetin H, Muntoni F, Beeson D, Hodilvala-Dilke K, Conti FJ, Multiple roles of integrin-alpha3 at the neuromuscular junction. J Cell Sci. 2017 May 15;130(10):1772-1784
5	J:341383 Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A, McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z, Rasin MR, Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nat Commun. 2023 Sep 27;14(1):6025
4*	J:80872 Sarria JC, Catsicas S, Hornung JP, Hirling H, Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system. Cell Tissue Res. 2002 Aug;309(2):209-18
2*	J:52209 Serpinskaya AS, Feng GP, Sanes JR, Craig AM, Synapse formation by hippocampal neurons from agrin- deficient mice. Dev Biol. 1999 JAN 1;205(1):65-78
2	J:277434 Shen C, Li L, Zhao K, Bai L, Wang A, Shu X, Xiao Y, Zhang J, Zhang K, Hui T, Chen W, Zhang B, Hsu W, Xiong WC, Mei L, Motoneuron Wnts regulate neuromuscular junction development. Elife. 2018 Aug 16;7:e34625
2	J:70506 Terrado J, Burgess RW, DeChiara T, Yancopoulos G, Sanes JR, Kato AC, Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos. J Neurosci. 2001 May 1;21(9):3144-50
1	J:224366 Uesaka T, Nagashimada M, Enomoto H, Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System. J Neurosci. 2015 Jul 8;35(27):9879-88
1	J:114095 Vergano-Vera E, Yusta-Boyo MJ, de Castro F, Bernad A, de Pablo F, Vicario-Abejon C, Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells. Development. 2006 Nov;133(21):4367-79
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
1	J:93205 Weiner JA, Koo SJ, Nicolas S, Fraboulet S, Pfaff SL, Pourquie O, Sanes JR, Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci. 2004 Sep;27(1):59-69
1	J:185531 Wu H, Lu Y, Barik A, Joseph A, Taketo MM, Xiong WC, Mei L, beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
1	J:311882 Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J, TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018 Sep 6;174(6):1477-1491.e19
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1	J:69772 Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N, Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001 Jun 1;105(5):587-97