Gene Expression Literature Summary

• Symbol: Kcnq1ot1
• Name: KCNQ1 overlapping transcript 1
• ID: MGI:1926855

29 matching records from 29 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E3.5	E4	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E18.5	E	P
In situ RNA (section)									1								1
RT-PCR	1	2	1	1	1	9	6	2	3	4	1		1	1	1	4	14
RNase protection										1		2				1	4
Primer Extension												1					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kcnq1ot1  KCNQ1 overlapping transcript 1   (Synonyms: Kvlqt1-as, Lit1, Tssc8)
Results	Reference
2	J:10529 Bastian H, Gruss P, A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
2	J:266304 Bogutz AB, Oh-McGinnis R, Jacob KJ, Ho-Lau R, Gu T, Gertsenstein M, Nagy A, Lefebvre L, Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage. PLoS Genet. 2018 Aug;14(8):e1007587
1	J:73452 Bourc'his D, Xu GL, Lin CS, Bollman B, Bestor TH, Dnmt3L and the establishment of maternal genomic imprints. Science. 2001 Dec 21;294(5551):2536-9
2*	J:96366 Cerrato F, Sparago A, Di Matteo I, Zou X, Dean W, Sasaki H, Smith P, Genesio R, Bruggemann M, Reik W, Riccio A, The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Hum Mol Genet. 2005 Feb 15;14(4):503-11
2	J:332803 de Waal E, Mak W, Calhoun S, Stein P, Ord T, Krapp C, Coutifaris C, Schultz RM, Bartolomei MS, In vitro culture increases the frequency of stochastic epigenetic errors at imprinted genes in placental tissues from mouse concepti produced through assisted reproductive technologies. Biol Reprod. 2014 Feb;90(2):22
1	J:79882 Fitzpatrick GV, Soloway PD, Higgins MJ, Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 2002 Nov;32(3):426-31
3	J:175802 Golding MC, Magri LS, Zhang L, Lalone SA, Higgins MJ, Mann MR, Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells. Development. 2011 Sep;138(17):3667-78
1*	J:118209 Green K, Lewis A, Dawson C, Dean W, Reinhart B, Chaillet JR, Reik W, A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm Genome. 2007 Jan;18(1):32-42
1	J:173801 Hudson QJ, Seidl CI, Kulinski TM, Huang R, Warczok KE, Bittner R, Bartolomei MS, Barlow DP, Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo. Dev Biol. 2011 May 15;353(2):420-31
2	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
6	J:190449 Korostowski L, Sedlak N, Engel N, The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart. PLoS Genet. 2012 Sep;8(9):e1002956
1	J:251884 Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ, The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Mol Cell. 2017 Oct 5;68(1):89-103.e7
1	J:153719 Lefebvre L, Mar L, Bogutz A, Oh-McGinnis R, Mandegar MA, Paderova J, Gertsenstein M, Squire JA, Nagy A, The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Hum Mol Genet. 2009 Nov 15;18(22):4255-67
3	J:114401 Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W, Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006 Nov;133(21):4203-10
2	J:94246 Lewis A, Mitsuya K, Umlauf D, Smith P, Dean W, Walter J, Higgins M, Feil R, Reik W, Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet. 2004 Dec;36(12):1291-5
2	J:82790 Mager J, Montgomery ND, de Villena FP, Magnuson T, Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003 Apr;33(4):502-7
3	J:108700 Mancini-Dinardo D, Steele SJ, Levorse JM, Ingram RS, Tilghman SM, Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82
3	J:163857 Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C, Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development. 2010 Aug 1;137(15):2493-9
1	J:202072 Negron-Perez VM, Echevarria FD, Huffman SR, Rivera RM, Determination of allelic expression of h19 in pre- and peri-implantation mouse embryos. Biol Reprod. 2013 Apr;88(4):97
1	J:112969 Ogawa H, Wu Q, Komiyama J, Obata Y, Kono T, Disruption of parental-specific expression of imprinted genes in uniparental fetuses. FEBS Lett. 2006 Oct 2;580(22):5377-84
1	J:130399 Oh R, Ho R, Mar L, Gertsenstein M, Paderova J, Hsien J, Squire JA, Higgins MJ, Nagy A, Lefebvre L, Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7. Mol Cell Biol. 2008 Feb;28(3):1092-103
2	J:161410 Oh-McGinnis R, Bogutz AB, Lee KY, Higgins MJ, Lefebvre L, Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol. 2010;10:50
4	J:144190 Redrup L, Branco MR, Perdeaux ER, Krueger C, Lewis A, Santos F, Nagano T, Cobb BS, Fraser P, Reik W, The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development. 2009 Feb;136(4):525-30
1	J:223238 Schultz BM, Gallicio GA, Cesaroni M, Lupey LN, Engel N, Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain. Nucleic Acids Res. 2015 Jan;43(2):745-59
1	J:275000 Sharma A, Lacko LA, Argueta LB, Glendinning MD, Stuhlmann H, miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Dev Biol. 2019 May 1;449(1):21-34
6	J:130529 Shin JY, Fitzpatrick GV, Higgins MJ, Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J. 2008 Jan 9;27(1):168-78
2	J:274138 Singh VB, Sribenja S, Wilson KE, Attwood KM, Hillman JC, Pathak S, Higgins MJ, Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Development. 2017 May 15;144(10):1820-1830
4*	J:94241 Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R, Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet. 2004 Dec;36(12):1296-300
3*	J:130398 Wagschal A, Sutherland HG, Woodfine K, Henckel A, Chebli K, Schulz R, Oakey RJ, Bickmore WA, Feil R, G9a histone methyltransferase contributes to imprinting in the mouse placenta. Mol Cell Biol. 2008 Feb;28(3):1104-13