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Gene Expression Literature Summary
Symbol
Name
ID
Sost
sclerostin
MGI:1921749

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E9.5 E10 E10.5 E11.5 E12.5 E13 E13.5 E14.5 E15.5 E16.5 E17.5 E18.5 E P
Immunohistochemistry (section) 1 1 1 1 1 3
In situ RNA (section) 1 1 1 3 2 1 1 1
In situ RNA (whole mount) 1 1 1 1 1 1
In situ reporter (knock in) 2 2 2 2 1 1 1
RT-PCR 2 1 1 2 1 4 2 6
cDNA clones 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Sost  sclerostin   (Synonyms: 5430411E23Rik)
Results  Reference
1J:261043 Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U, Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242
6J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79
8J:203431 Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG, Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 1;383(1):90-105
1J:219045 Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X, Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013;11:107
1J:225092 Duverger O, Isaac J, Zah A, Hwang J, Berdal A, Lian JB, Morasso MI, In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones. J Cell Physiol. 2013 Mar;228(3):654-64
1J:216098 Ellies DL, Economou A, Viviano B, Rey JP, Paine-Saunders S, Krumlauf R, Saunders S, Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257
5J:128100 Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R, Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res. 2006 Nov;21(11):1738-49
2J:176483 Holmes G, Bromage TG, Basilico C, The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice. Bone. 2011 Oct;49(4):653-61
2J:149465 Holmes G, Rothschild G, Roy UB, Deng CX, Mansukhani A, Basilico C, Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol. 2009 Apr 15;328(2):273-84
1J:235526 Jauregui EJ, Akil O, Acevedo C, Hall-Glenn F, Tsai BS, Bale HA, Liebenberg E, Humphrey MB, Ritchie RO, Lustig LR, Alliston T, Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone. 2016 Aug;89:7-15
1J:182873 Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD, PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1;124(Pt 5):745-54
4J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11
5*J:170473 Naka T, Yokose S, Spatiotemporal expression of sclerostin in odontoblasts during embryonic mouse tooth morphogenesis. J Endod. 2011 Mar;37(3):340-5
4J:92630 Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M, Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology. 2004 Oct;145(10):4685-92
3J:132979 Potok MA, Cha KB, Hunt A, Brinkmeier ML, Leitges M, Kispert A, Camper SA, WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn. 2008 Apr;237(4):1006-20
2J:255349 Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P, Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142
7*J:117264 van Bezooijen RL, Deruiter MC, Vilain N, Monteiro RM, Visser A, van der Wee-Pals L, van Munsteren CJ, Hogendoorn PC, Aguet M, Mummery CL, Papapoulos SE, Ten Dijke P, Lowik CW, SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development. Dev Dyn. 2007 Feb;236(2):606-12
1*J:86838 Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D, Jonas M, Kovacevich BR, Staehling-Hampton K, Appleby M, Brunkow ME, Latham JA, Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 2003 Dec 1;22(23):6267-76
1J:165583 Yang F, Tang W, So S, de Crombrugghe B, Zhang C, Sclerostin is a direct target of osteoblast-specific transcription factor osterix. Biochem Biophys Res Commun. 2010 Oct 1;400(4):684-8

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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory