Gene Expression Literature Summary

• Symbol: Adar
• Name: adenosine deaminase, RNA-specific
• ID: MGI:1889575

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E9	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E18.5	E19	P
Immunohistochemistry (section)									1	1	1		1	1	1						1
In situ RNA (section)											1			1	2		1	1			3
In situ RNA (whole mount)														1
In situ reporter (knock in)													1								1
Western blot							1	1		3	1	1	2	1	1	1	1		1	1	3
RT-PCR	1	1	1	1	1	1				1	1			1					1		8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Adar  adenosine deaminase, RNA-specific   (Synonyms: ADAR1, Adar1p110, Adar1p150, mZaADAR)
Results	Reference
2*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
3	J:310901 de Reuver R, Dierick E, Wiernicki B, Staes K, Seys L, De Meester E, Muyldermans T, Botzki A, Lambrecht BN, Van Nieuwerburgh F, Vandenabeele P, Maelfait J, ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation. Cell Rep. 2021 Aug 10;36(6):109500
2	J:330287 de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J, ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. Nature. 2022 Jul;607(7920):784-789
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
7*	J:200651 Garcia-Lopez J, Hourcade Jde D, Del Mazo J, Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos. Nucleic Acids Res. 2013 May 1;41(10):5483-93
1	J:317546 Heraud-Farlow JE, Chalk AM, Linder SE, Li Q, Taylor S, White JM, Pang L, Liddicoat BJ, Gupte A, Li JB, Walkley CR, Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis. Genome Biol. 2017 Sep 5;18(1):166
1	J:229294 Hsieh CL, Liu H, Huang Y, Kang L, Chen HW, Chen YT, Wee YR, Chen SJ, Tan BC, ADAR1 deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions. Cell Death Differ. 2014 May;21(5):707-19
6	J:306164 Kim JI, Nakahama T, Yamasaki R, Costa Cruz PH, Vongpipatana T, Inoue M, Kanou N, Xing Y, Todo H, Shibuya T, Kato Y, Kawahara Y, RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain. PLoS Genet. 2021 May;17(5):e1009516
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
2	J:226177 Liddicoat BJ, Piskol R, Chalk AM, Ramaswami G, Higuchi M, Hartner JC, Li JB, Seeburg PH, Walkley CR, RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science. 2015 Sep 4;349(6252):1115-20
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
4	J:197985 Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K, ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89
3*	J:333559 Rupani DN, Thege FI, Chandra V, Rajaei H, Cowan RW, Wormann SM, Le Roux O, Malaney P, Manning SL, Hashem J, Bailey-Lundberg J, Rhim AD, McAllister F, Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
2	J:243912 Snyder EM, Licht K, Braun RE, Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1. Biol Reprod. 2017 Jan 01;96(1):244-253
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3*	J:306172 Wahlstedt H, Daniel C, Enstero M, Ohman M, Large-scale mRNA sequencing determines global regulation of RNA editing during brain development. Genome Res. 2009 Jun;19(6):978-86
5*	J:65981 Wang Q, Khillan J, Gadue P, Nishikura K, Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science. 2000 Dec 1;290(5497):1765-8
3	J:87714 Wang Q, Miyakoda M, Yang W, Khillan J, Stachura DL, Weiss MJ, Nishikura K, Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem. 2004 Feb 6;279(6):4952-61