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Gene Expression Literature Summary
Symbol
Name
ID
Slc12a5
solute carrier family 12, member 5
MGI:1862037

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 1 2 1 1 2 2 1 2 2 1 2 2 1 3 2 5
In situ RNA (section) 2 2 2 3 3 1 1 5 4
In situ RNA (whole mount) 1 1 1 1
Northern blot 2
Western blot 1 2 4 3
RT-PCR 1 1 1 1
cDNA clones 1 1
RNase protection 1 1 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Slc12a5  solute carrier family 12, member 5   (Synonyms: KCC2, mKIAA1176)
Results  Reference
3*J:81579 Aguado F, Carmona MA, Pozas E, Aguilo A, Martinez-Guijarro FJ, Alcantara S, Borrell V, Yuste R, Ibanez CF, Soriano E, BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2. Development. 2003 Apr;130(7):1267-80
2J:174114 Batista-Brito R, Machold R, Klein C, Fishell G, Gene expression in cortical interneuron precursors is prescient of their mature function. Cereb Cortex. 2008 Oct;18(10):2306-17
1J:86183 Boettger T, Rust MB, Maier H, Seidenbecher T, Schweizer M, Keating DJ, Faulhaber J, Ehmke H, Pfeffer C, Scheel O, Lemcke B, Horst J, Leuwer R, Pape HC, Volkl H, Hubner CA, Jentsch TJ, Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J. 2003 Oct 15;22(20):5422-34
1J:147160 Chambers D, Wilson LJ, Alfonsi F, Hunter E, Saxena U, Blanc E, Lumsden A, Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6
8J:133937 Delpy A, Allain AE, Meyrand P, Branchereau P, NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron. J Physiol. 2008 Feb 15;586(4):1059-75
1J:196342 Denaxa M, Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, Pachnis V, Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep. 2012 Nov 29;2(5):1351-62
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5J:163030 Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E, Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci. 2010 Jun;31(12):2142-55
2*J:94053 Hubner CA, Hentschke M, Jacobs S, Hermans-Borgmeyer I, Expression of the sodium-driven chloride bicarbonate exchanger NCBE during prenatal mouse development. Gene Expr Patterns. 2004 Dec;5(2):219-23
6J:69625 Hubner CA, Stein V, Hermans-Borgmeyer I, Meyer T, Ballanyi K, Jentsch TJ, Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition. Neuron. 2001 May;30(2):515-24
3J:94810 Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa TO, Taketo MM, Fukuda A, Kawakami K, Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci. 2004 Nov 24;24(47):10693-701
2J:180218 Khalilov I, Chazal G, Chudotvorova I, Pellegrino C, Corby S, Ferrand N, Gubkina O, Nardou R, Tyzio R, Yamamoto S, Jentsch TJ, Hubner CA, Gaiarsa JL, Ben-Ari Y, Medina I, Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. Front Cell Neurosci. 2011;5:23
7J:193557 Kosaka Y, Kin H, Tatetsu M, Uema I, Takayama C, Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord. Brain Res. 2012 Nov 27;1486:39-52
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2J:98308 Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL, Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 2005 Apr 7;46(1):37-49
1J:193641 Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, Banfi B, A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
1J:156036 Schilling K, Oberdick J, The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Cerebellum. 2009 Dec;8(4):477-89
13J:87826 Stein V, Hermans-Borgmeyer I, Jentsch TJ, Hubner CA, Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride. J Comp Neurol. 2004 Jan 1;468(1):57-64
4J:119945 Takayama C, Inoue Y, Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum. Neurosci Res. 2007 Feb;57(2):322-5
3J:101079 Tornberg J, Voikar V, Savilahti H, Rauvala H, Airaksinen MS, Behavioural phenotypes of hypomorphic KCC2-deficient mice. Eur J Neurosci. 2005 Mar;21(5):1327-37
6J:126757 Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS, A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem. 2007 Oct 19;282(42):30570-6
3J:149913 Uvarov P, Ludwig A, Markkanen M, Soni S, Hubner CA, Rivera C, Airaksinen MS, Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J Biol Chem. 2009 May 15;284(20):13696-704
2J:102886 Uvarov P, Pruunsild P, Timmusk T, Airaksinen MS, Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene. J Neurochem. 2005 Nov;95(4):1144-55
3J:122318 Wojcik SM, Katsurabayashi S, Guillemin I, Friauf E, Rosenmund C, Brose N, Rhee JS, A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron. 2006 May 18;50(4):575-87

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory