Gene Expression Literature Summary

• Symbol: Foxf2
• Name: forkhead box F2
• ID: MGI:1347479

44 matching records from 44 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)					1		1		2		3		2				1		1	2	1	2
In situ RNA (section)	1	1	4	2	2	2	2	1	6	1	6	1	8	2	3	1		1	1		2	4
In situ RNA (whole mount)	2		2		7	1	3		5		3		1		1						1
In situ reporter (knock in)											1
Northern blot							1
RT-PCR		2	5		5		1				3							1	1	1		4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxf2  forkhead box F2   (Synonyms: Fkh20, FREAC2, LUN)
Results	Reference
8	J:62069 Aitola M, Carlsson P, Mahlapuu M, Enerback S, Pelto-Huikko M, Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions. Dev Dyn. 2000 May;218(1):136-49
2	J:274580 Bademci G, Abad C, Incesulu A, Elian F, Reyahi A, Diaz-Horta O, Cengiz FB, Sineni CJ, Seyhan S, Atli EI, Basmak H, Demir S, Nik AM, Footz T, Guo S, Duman D, Fitoz S, Gurkan H, Blanton SH, Walter MA, Carlsson P, Walz K, Tekin M, FOXF2 is required for cochlear development in humans and mice. Hum Mol Genet. 2019 Apr 15;28(8):1286-1297
2	J:244068 Bohnenpoll T, Wittern AB, Mamo TM, Weiss AC, Rudat C, Kleppa MJ, Schuster-Gossler K, Wojahn I, Ludtke TH, Trowe MO, Kispert A, A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development. PLoS Genet. 2017 Aug;13(8):e1006951
5	J:279187 Bolte C, Ren X, Tomley T, Ustiyan V, Pradhan A, Hoggatt A, Kalin TV, Herring BP, Kalinichenko VV, Forkhead box F2 regulation of platelet-derived growth factor and myocardin/serum response factor signaling is essential for intestinal development. J Biol Chem. 2015 Mar 20;290(12):7563-75
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:311497 Everson JL, Fink DM, Yoon JW, Leslie EJ, Kietzman HW, Ansen-Wilson LJ, Chung HM, Walterhouse DO, Marazita ML, Lipinski RJ, Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis. Development. 2017 Jun 1;144(11):2082-2091
1	J:294823 Fabik J, Kovacova K, Kozmik Z, Machon O, Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. Biol Open. 2020 Jul 2;9(6):bio052043
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:161785 Gu WX, Kania A, Identification of genes controlled by LMX1B in E13.5 mouse limbs. Dev Dyn. 2010 Aug;239(8):2246-55
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
2*	J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
2*	J:228853 Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP, Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct;10(10):e1004604
1	J:203847 Hoggatt AM, Kim JR, Ustiyan V, Ren X, Kalin TV, Kalinichenko VV, Herring BP, The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells. J Biol Chem. 2013 Oct 4;288(40):28477-87
3	J:89445 Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP, Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51
2	J:331097 Jia D, Zhou Z, Kwon OJ, Zhang L, Wei X, Zhang Y, Yi M, Roudier MP, Regier MC, Dumpit R, Nelson PS, Headley M, True L, Lin DW, Morrissey C, Creighton CJ, Xin L, Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity. Nat Commun. 2022 Nov 11;13(1):6828
1	J:147277 Lan Y, Jiang R, Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96
2*	J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
1	J:243780 Li F, Fu G, Liu Y, Miao X, Li Y, Yang X, Zhang X, Yu D, Gan L, Qiu M, Chen Y, Zhang Z, Zhang Z, ISLET1-Dependent beta-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw. Mol Cell Biol. 2017 Apr 15;37(8)
1	J:278915 Lopez SH, Avetisyan M, Wright CM, Mesbah K, Kelly RG, Moon AM, Heuckeroth RO, Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit. Dev Biol. 2018 Dec 1;444 Suppl 1:S337-S351
2*	J:130227 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI, Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan;8(2):124-39
2	J:241005 Millington G, Elliott KH, Chang YT, Chang CF, Dlugosz A, Brugmann SA, Cilia-dependent GLI processing in neural crest cells is required for tongue development. Dev Biol. 2017 Apr 15;424(2):124-137
1*	J:110719 Moreno-Barriuso N, Lopez-Malpartida AV, de Pablo F, Pichel JG, Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 2006 Aug;235(8):2040-50
8*	J:234115 Nik AM, Johansson JA, Ghiami M, Reyahi A, Carlsson P, Foxf2 is required for secondary palate development and Tgfbeta signaling in palatal shelf mesenchyme. Dev Biol. 2016 Jul 1;415(1):14-23
3	J:314598 Nik AM, Reyahi A, Ponten F, Carlsson P, Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. Gastroenterology. 2013 May;144(5):1001-11
8*	J:88922 Ormestad M, Astorga J, Carlsson P, Differences in the embryonic expression patterns of mouse Foxf1 and -2 match their distinct mutant phenotypes. Dev Dyn. 2004 Feb;229(2):328-33
1	J:106013 Ormestad M, Astorga J, Landgren H, Wang T, Johansson BR, Miura N, Carlsson P, Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development. 2006 Mar;133(5):833-43
1	J:344102 Racedo SE, Liu Y, Shi L, Zheng D, Morrow BE, Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
2	J:331873 Rasile M, Lauranzano E, Faggiani E, Ravanelli MM, Colombo FS, Mirabella F, Corradini I, Malosio ML, Borreca A, Focchi E, Pozzi D, Giorgino T, Barajon I, Matteoli M, Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring. EMBO J. 2022 Dec 1;41(23):e111192
6	J:239656 Reyahi A, Nik AM, Ghiami M, Gritli-Linde A, Ponten F, Johansson BR, Carlsson P, Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. Dev Cell. 2015 Jul 06;34(1):19-32
1	J:267472 Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP, Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10615-E10624
1	J:155112 Tsiairis CD, McMahon AP, An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009 Dec 1;19(22):1912-7
1	J:266598 Ustiyan V, Bolte C, Zhang Y, Han L, Xu Y, Yutzey KE, Zorn AM, Kalin TV, Shannon JM, Kalinichenko VV, FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol. 2018 Nov 1;443(1):50-63
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
14	J:84053 Wang T, Tamakoshi T, Uezato T, Shu F, Kanzaki-Kato N, Fu Y, Koseki H, Yoshida N, Sugiyama T, Miura N, Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate. Dev Biol. 2003 Jul 1;259(1):83-94
2	J:309090 Xu J, Liu H, Lan Y, Adam M, Clouthier DE, Potter S, Jiang R, Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. Elife. 2019 Jan 14;8:e40315
4	J:232140 Xu J, Liu H, Lan Y, Aronow BJ, Kalinichenko VV, Jiang R, A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genet. 2016 Jan;12(1):e1005769
1*	J:306327 Xu J, Liu H, Lan Y, Jiang R, Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Front Cell Dev Biol. 2021;9:665109
2	J:287549 Xu J, Liu H, Lan Y, Park JS, Jiang R, Genome-wide Identification of Foxf2 Target Genes in Palate Development. J Dent Res. 2020 Apr;99(4):463-471
5*	J:162778 Yang Z, Hikosaka K, Sharkar MT, Tamakoshi T, Chandra A, Wang B, Itakura T, Xue X, Uezato T, Kimura W, Miura N, The mouse forkhead gene Foxp2 modulates expression of the lung genes. Life Sci. 2010 Jul 3;87(1-2):17-25
1	J:312414 Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, Yoshida K, Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun Biol. 2021 Oct 20;4(1):1204
2*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
3	J:298652 Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K, The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. Elife. 2020 Aug 6;9:e57381
2	J:331054 Zhang W, Yu J, Fu G, Li J, Huang H, Liu J, Yu D, Qiu M, Li F, ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development. Development. 2022 Nov 1;149(21):dev200788