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Gene Expression Literature Summary
Symbol
Name
ID
Map3k12
mitogen-activated protein kinase kinase kinase 12
MGI:1346881

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E7.5 E8.5 E9.5 E10 E10.5 E11 E11.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E P
Immunohistochemistry (section) 1 2 1 3 2 1 2 1 2 1 1 1
In situ RNA (section) 1 1 1 1 1 1 1 2
In situ RNA (whole mount) 1 1 1 1 1
Northern blot 1 1 1 1 2
Western blot 2 1 2 2 1
RT-PCR 1 2
cDNA clones 1 1 1 1
RNase protection 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Map3k12  mitogen-activated protein kinase kinase kinase 12   (Synonyms: DLK, MUK, Zpk)
Results  Reference
4J:35108 Blouin R, Beaudoin J, Bergeron P, Nadeau A, Grondin G, Cell-specific expression of the ZPK gene in adult mouse tissues. DNA Cell Biol. 1996 Aug;15(8):631-42
5J:157201 Eto K, Kawauchi T, Osawa M, Tabata H, Nakajima K, Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth. Neurosci Res. 2010 Jan;66(1):37-45
1J:88445 Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, Azoulai D, Reiner O, DCX, a new mediator of the JNK pathway. EMBO J. 2004 Feb 25;23(4):823-32
1J:176956 Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW, DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol. 2011 Sep 5;194(5):751-64
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3J:190408 Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V, The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. J Biol Chem. 2012 Aug 31;287(36):30063-72
4J:115575 Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S, The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci. 2006 Nov 15;26(46):11992-2002
8*J:78683 Hirai S, Kawaguchi A, Hirasawa R, Baba M, Ohnishi T, Ohno S, MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development. 2002 Oct;129(19):4483-95
5*J:96323 Hirai S, Kawaguchi A, Suenaga J, Ono M, Cui de F, Ohno S, Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo. Gene Expr Patterns. 2005 Apr;5(4):517-23
8*J:20630 Holzman LB, Merritt SE, Fan G, Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. J Biol Chem. 1994 Dec 9;269(49):30808-17
1J:215576 Itoh T, Horiuchi M, Ikeda RH Jr, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A, ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 2014 Aug 6;34(32):10729-42
8*J:37702 Nadeau A, Grondin G, Blouin R, In situ hybridization analysis of ZPK gene expression during murine embryogenesis. J Histochem Cytochem. 1997 Jan;45(1):107-18
1J:149890 Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HJ, Okano H, Nakayama KI, Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43
2J:190524 Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y, Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
2*J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory