About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Mapk8
mitogen-activated protein kinase 8
MGI:1346861

91 matching records from 91 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1 E1.5 E2 E2.5 E3.5 E7 E8.5 E9 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19.5 E P
Immunohistochemistry (section) 1 1 4 3 1 3 6 2 2 1 1 1 3 1 4 1 4
In situ RNA (section) 2 1 1 1
Immunohistochemistry (whole mount) 1 1 1 1
In situ RNA (whole mount) 1 1 1 1
Northern blot 1 1 1 1 1
Western blot 2 2 2 7 3 1 9 4 1 3 2 3 4 1 1 2 6 1 2 28
RT-PCR 1 1 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Mapk8  mitogen-activated protein kinase 8   (Synonyms: c-Jun N-terminal kinase, JNK1, Prkm8)
Results  Reference
1J:160730 Alavian KN, Sgado P, Alberi L, Subramaniam S, Simon HH, Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 2009;4:11
2J:141601 Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, Tuckermann J, Schutz G, Perez P, Glucocorticoid receptor is required for skin barrier competence. Endocrinology. 2008 Mar;149(3):1377-88
1J:153050 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A, Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
1J:123909 Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N, Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
1J:239523 Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R, Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628
1J:171873 Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R, Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. J Clin Invest. 2010 Dec 1;120(12):4353-65
2J:143322 Chen Y, Stump RJ, Lovicu FJ, Shimono A, McAvoy JW, Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Dev Biol. 2008 Dec 1;324(1):161-76
2*J:96871 Chi H, Sarkisian MR, Rakic P, Flavell RA, Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3846-51
3J:175562 Cho IH, Lee KW, Ha HY, Han PL, JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains. Exp Mol Med. 2011 Aug 31;43(8):462-70
2*J:101370 Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM, The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Mol Cell Biol. 2005 Sep;25(18):8323-33
1J:228212 Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C, FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5
2J:169972 Combs MD, Yutzey KE, VEGF and RANKL regulation of NFATc1 in heart valve development. Circ Res. 2009 Sep 11;105(6):565-74
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:114498 Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL, Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol. 2006 Oct 9;175(1):121-33
2J:88445 Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, Azoulai D, Reiner O, DCX, a new mediator of the JNK pathway. EMBO J. 2004 Feb 25;23(4):823-32
1J:191095 Gierl MS, Gruhn WH, von Seggern A, Maltry N, Niehrs C, GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012 Nov 13;23(5):1032-42
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:95744 Ha HY, Cho IH, Lee KW, Lee KW, Song JY, Kim KS, Yu YM, Lee JK, Song JS, Yang SD, Shin HS, Han PL, The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1. Dev Biol. 2005 Jan 1;277(1):184-99
1J:231463 Haque K, Pandey AK, Zheng HW, Riazuddin S, Sha SH, Puligilla C, MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. J Neurosci. 2016 Jan 27;36(4):1347-61
1J:115575 Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S, The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci. 2006 Nov 15;26(46):11992-2002
3*J:78683 Hirai S, Kawaguchi A, Hirasawa R, Baba M, Ohnishi T, Ohno S, MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development. 2002 Oct;129(19):4483-95
1J:238096 Houlihan SL, Lanctot AA, Guo Y, Feng Y, Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. Elife. 2016 Sep 24;5
2J:170883 Huang J, Davis EC, Chapman SL, Budatha M, Marmorstein LY, Word RA, Yanagisawa H, Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res. 2010 Feb 19;106(3):583-92
1*J:112731 Huang J, Sakai R, Furuichi T, The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol Biol Cell. 2006 Jul;17(7):3187-96
6J:153222 Iwawaki T, Akai R, Yamanaka S, Kohno K, Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
1J:184014 Jin YR, Han XH, Taketo MM, Yoon JK, Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development. 2012 May;139(10):1821-30
1*J:136160 Joesting MS, Cheever TR, Volzing KG, Yamaguchi TP, Wolf V, Naf D, Rubin JS, Marker PC, Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol. 2008 May 1;317(1):161-73
1J:240480 Kapali J, Kabat BE, Schmidt KL, Stallings CE, Tippy M, Jung DO, Edwards BS, Nantie LB, Raeztman LT, Navratil AM, Ellsworth BS, Foxo1 Is Required for Normal Somatotrope Differentiation. Endocrinology. 2016 Nov;157(11):4351-4363
2*J:85160 Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ, Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9843-8
8J:54653 Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA, The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 1999 Apr;22(4):667-76
1J:238086 Kusano R, Fujita K, Shinoda Y, Nagaura Y, Kiyonari H, Abe T, Watanabe T, Matsui Y, Fukaya M, Sakagami H, Sato T, Funahashi JI, Ohnishi M, Tamura S, Kobayashi T, Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain. FEBS Lett. 2016 Oct;590(20):3606-3615
2*J:102474 Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT, RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15030-5
1J:198191 Li C, Li A, Xing Y, Li M, Chan B, Ouyang R, Taketo MM, Kucherlapati R, Borok Z, Minoo P, Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1;378(1):13-24
1J:167714 Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W, Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development. 2011 Jan;138(2):303-15
1J:177567 Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W, Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
1J:204229 Li L, Wang Y, Lin M, Yuan G, Yang G, Zheng Y, Chen Y, Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PLoS One. 2013;8(6):e66107
1J:208533 Li X, Weng H, Xu C, Reece EA, Yang P, Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy. Diabetes. 2012 Aug;61(8):2084-92
1J:208480 Li X, Xu C, Yang P, c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes. 2013 Feb;62(2):599-608
1J:222257 Liu Y, Wang M, Zhao W, Yuan X, Yang X, Li Y, Qiu M, Zhu XJ, Zhang Z, Gpr177-mediated Wnt Signaling Is Required for Secondary Palate Development. J Dent Res. 2015 Jul;94(7):961-7
3J:98386 Maekawa M, Yamamoto T, Tanoue T, Yuasa Y, Chisaka O, Nishida E, Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development. 2005 Apr;132(8):1773-83
1J:102860 Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, Shimada K, Morohashi K, A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005 May;10(5):421-34
1*J:81668 Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA, Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Dev Dyn. 2001 Apr;220(4):337-49
2J:123406 Miquelajauregui A, Van de Putte T, Polyakov A, Nityanandam A, Boppana S, Seuntjens E, Karabinos A, Higashi Y, Huylebroeck D, Tarabykin V, Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12919-24
2J:109570 Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M, Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J Neurochem. 2006 Jun;97(5):1431-46
1J:184368 Mukhopadhyay P, Brock G, Webb C, Pisano MM, Greene RM, Strain-specific modifier genes governing craniofacial phenotypes. Birth Defects Res A Clin Mol Teratol. 2012 Mar;94(3):162-75
2J:211632 Myers AK, Meechan DW, Adney DR, Tucker ES, Cortical interneurons require Jnk1 to enter and navigate the developing cerebral cortex. J Neurosci. 2014 Jun 4;34(23):7787-801
1J:172560 Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Rasanen J, Vainio SJ, Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression. Cardiovasc Res. 2010 Jan 1;85(1):100-9
3J:147600 Ni HM, Chen X, Shi YH, Liao Y, Beg AA, Fan J, Yin XM, Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice. J Biol Chem. 2009 Feb 13;284(7):4373-82
6J:235530 Niu W, Wang Y, Wang Z, Xin Q, Wang Y, Feng L, Zhao L, Wen J, Zhang H, Wang C, Xia G, JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice. Development. 2016 May 15;143(10):1778-87
1J:233662 Noda K, Mishina Y, Komatsu Y, Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2016 Jul 15;415(2):306-13
1J:240082 Noh H, Lee H, Park E, Park S, Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development. 2016 Feb 01;143(3):461-72
1*J:166841 Nordstrand LM, Svard J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A, Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010;5(11):e13827
1J:242220 Ohlen SB, Russell ML, Brownstein MJ, Lefcort F, BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc Natl Acad Sci U S A. 2017 May 09;114(19):5035-5040
1J:121367 Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD, Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res. 2006 Mar 31;98(6):837-45
1J:204152 Onishi K, Shafer B, Lo C, Tissir F, Goffinet AM, Zou Y, Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
1J:169531 Paina S, Garzotto D, Demarchis S, Marino M, Moiana A, Conti L, Cattaneo E, Perera M, Corte G, Calautti E, Merlo GR, Wnt5a is a transcriptional target of dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo. J Neurosci. 2011 Feb 16;31(7):2675-87
1J:226897 Parker A, Cross SH, Jackson IJ, Hardisty-Hughes R, Morse S, Nicholson G, Coghill E, Bowl MR, Brown SD, The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells. Dis Model Mech. 2015 Dec 1;8(12):1555-68
1J:186307 Peng C, Ye J, Yan S, Kong S, Shen Y, Li C, Li Q, Zheng Y, Deng K, Xu T, Tao W, Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Aug 1;
1J:160742 Pla P, Hirsch MR, Le Crom S, Reiprich S, Harley VR, Goridis C, Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors. Neural Dev. 2008;3:14
1J:154601 Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V, Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci. 2009 Nov;12(11):1373-80
1J:169765 Shafer B, Onishi K, Lo C, Colakoglu G, Zou Y, Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance. Dev Cell. 2011 Feb 15;20(2):177-91
1*J:85547 Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG, Warburton D, TACE is required for fetal murine cardiac development and modeling. Dev Biol. 2003 Sep 15;261(2):371-80
3J:117790 Singh S, Yin X, Pisano MM, Greene RM, Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development. Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):35-44
1J:76484 Sordella R, Classon M, Hu KQ, Matheson SF, Brouns MR, Fine B, Le Zhang, Takami H, Yamada Y, Settleman J, Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development. Dev Cell. 2002 May;2(5):553-65
1J:152701 Suriben R, Kivimae S, Fisher DA, Moon RT, Cheyette BN, Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep;41(9):977-85
1*J:221495 Tapia O, Fong LG, Huber MD, Young SG, Gerace L, Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015;10(3):e0116196
3J:177534 Teraishi T, Miura K, Detection of phosphorylated mitogen-activated protein kinase in the developing spinal cord of the mouse embryo. Biochem Biophys Res Commun. 2011 Sep 16;413(1):87-91
1J:133397 Teraishi T, Miura K, Imaki J, An optimized immunohistochemical method for detection of phosphorylated mitogen-activated protein kinases. J Immunol Methods. 2008 Jan 31;330(1-2):34-43
1J:194895 Upadhya D, Ogata M, Reneker LW, MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013 Apr;140(7):1573-82
2J:83651 Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R, Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003 Jun;4(6):533-9
1J:226104 Wang F, Wu Y, Quon MJ, Li X, Yang P, ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99
4J:129038 Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C, Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
1J:146172 Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK, Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009 Jan 12;184(1):143-58
1J:91673 Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX, Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem. 2004 Jul 9;279(28):29606-14
1J:93433 Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ, The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14114-9
1J:149874 Wetzel MK, Naska S, Laliberte CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR, p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron. 2008 Sep 11;59(5):708-21
1J:185554 Wu CI, Hoffman JA, Shy BR, Ford EM, Fuchs E, Nguyen H, Merrill BJ, Function of Wnt/beta-catenin in counteracting Tcf3 repression through the Tcf3-beta-catenin interaction. Development. 2012 Jun;139(12):2118-29
1J:119283 Xie L, Overbeek PA, Reneker LW, Ras signaling is essential for lens cell proliferation and lens growth during development. Dev Biol. 2006 Oct 15;298(2):403-14
1J:184324 Xu K, Wu X, Shapiro E, Huang H, Zhang L, Hickling D, Deng Y, Lee P, Li J, Lepor H, Grishina I, Bmp7 functions via a polarity mechanism to promote cloacal septation. PLoS One. 2012;7(1):e29372
6J:177905 Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H, Stress-Activated Protein Kinase MKK7 Regulates Axon Elongation in the Developing Cerebral Cortex. J Neurosci. 2011 Nov 16;31(46):16872-16883
1J:176219 Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, Tanoue A, The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination. J Neurosci. 2011 Aug 31;31(35):12579-92
1J:218803 Yang G, Yuan G, Ye W, Cho KW, Chen Y, An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis. J Biol Chem. 2014 Nov 7;289(45):31492-502
1J:119920 Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ, Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development. 2007 Feb;134(4):789-99
2*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1J:232056 Yu J, Zhang F, Wang S, Zhang Y, Fan M, Xu Z, TAK1 is activated by TGF-beta signaling and controls axonal growth during brain development. J Mol Cell Biol. 2014 Aug;6(4):349-51
2J:137275 Yu Z, Bhandari A, Mannik J, Pham T, Xu X, Andersen B, Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure. Dev Biol. 2008 Jul 1;319(1):56-67
2J:217590 Yuan G, Yang G, Zheng Y, Zhu X, Chen Z, Zhang Z, Chen Y, The non-canonical BMP and Wnt/beta-catenin signaling pathways orchestrate early tooth development. Development. 2015 Jan 1;142(1):128-39
4J:95085 Zhong W, Sun T, Wang QT, Wang Y, Xie Y, Johnson A, Leach R, Puscheck EE, Rappolee DA, SAPKgamma/JNK1 and SAPKalpha/JNK2 mRNA transcripts are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells. Fertil Steril. 2004 Oct;82 Suppl 3:1140-8
1J:201137 Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T, Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-E3829
1J:228307 Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, He L, Cang Y, Boast S, Chen YH, Thibault H, Scherrer-Crosbie M, Goff SP, Li B, Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71
1J:229317 Zhu XJ, Liu Y, Yuan X, Wang M, Zhao W, Yang X, Zhang X, Hsu W, Qiu M, Zhang Z, Zhang Z, Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis. Dev Dyn. 2016 Mar;245(3):414-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory