Gene Expression Literature Summary

• Symbol: Prkaa2
• Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
• ID: MGI:1336173

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2	E3.5	E4	E7.5	E8	E8.5	E9.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E20	P
Immunohistochemistry (section)		1	1						1					1	2										3
In situ RNA (section)									1						2
In situ RNA (whole mount)					1	1	1			1
In situ reporter (knock in)																									1
Northern blot								1						1				1					1		1
Western blot		1		1	1		1		1	2	3	1	2		4	1	2		1	1	4	5		1	18
RT-PCR	1					1				1							1		1			1			2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prkaa2  protein kinase, AMP-activated, alpha 2 catalytic subunit   (Synonyms: 2310008I11Rik, AMPKalpha2)
Results	Reference
1	J:232360 Anastasiou V, Ninou E, Alexopoulou D, Stertmann J, Muller A, Dahl A, Solimena M, Speier S, Serafimidis I, Gavalas A, Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia. 2016 Jan;59(1):139-50
6*	J:240023 Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL, Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development. 2017 Apr 01;144(7):1235-1241
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:236179 Bowman CE, Zhao L, Hartung T, Wolfgang MJ, Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104
2	J:335231 Bustamante-Barrientos FA, Mendez-Ruette M, Molina L, Koning T, Ehrenfeld P, Gonzalez CB, Wyneken U, Henzi R, Batiz LF, Alpha-SNAP (M105I) mutation promotes neuronal differentiation of neural stem/progenitor cells through overactivation of AMPK. Front Cell Dev Biol. 2023;11:1061777
1	J:329985 Chae SA, Son JS, de Avila JM, Du M, Zhu MJ, Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 3;
2	J:302676 Cheong H, Wu J, Gonzales LK, Guttentag SH, Thompson CB, Lindsten T, Analysis of a lung defect in autophagy-deficient mouse strains. Autophagy. 2014 Jan;10(1):45-56
1	J:330942 Chu Q, Yao C, Qi X, Stripp BR, Tang N, STK11 is required for the normal program of ciliated cell differentiation in airways. Cell Discov. 2019;5:36
2*	J:218247 Cossette SM, Gastonguay AJ, Bao X, Lerch-Gaggl A, Zhong L, Harmann LM, Koceja C, Miao RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP, Ramchandran R, Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61
3	J:146618 Dasgupta B, Milbrandt J, AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev Cell. 2009 Feb;16(2):256-70
1	J:317793 De Zio D, Molinari F, Rizza S, Gatta L, Ciotti MT, Salvatore AM, Mathiassen SG, Cwetsch AW, Filomeni G, Rosano G, Ferraro E, Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015 Nov;72(21):4173-91
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:342550 Gupta N, Soriano-Ubeda C, Stein P, Savy V, Papas BN, Ardestani G, Carvacho I, Alfandari D, Williams CJ, Fissore RA, Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes. Cell Rep. 2023 Oct 31;42(10):113232
1	J:134078 Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA, Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol. 2008 Apr;28(7):2414-25
1	J:305429 Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A, Kispert A, Trowe MO, Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
1	J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208
1	J:335218 Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C, Tassinari M, Maulide N, Rulicke T, Menche J, Hippenmeyer S, Novarino G, Large neutral amino acid levels tune perinatal neuronal excitability and survival. Cell. 2023 Apr 27;186(9):1950-1967.e25
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:223226 Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y, Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo. J Cell Sci. 2015 Mar 1;128(5):1011-22
2	J:313922 Kuiper-Makris C, Zanetti D, Vohlen C, Fahle L, Muller M, Odenthal M, Felderhoff-Muser U, Dotsch J, Alejandre Alcazar MA, Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function. Sci Rep. 2020 Dec 28;10(1):22395
2	J:320621 Lee HY, Wei D, Loeken MR, Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. Diabetes Metab Res Rev. 2014 Jan;30(1):23-30
1	J:301834 Li G, Xu C, Lin X, Qu L, Xia D, Hongdu B, Xia Y, Wang X, Lou Y, He Q, Ma D, Chen Y, Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality. Cell Death Dis. 2017 May 25;8(5):e2811
2*	J:317554 Louden ED, Luzzo KM, Jimenez PT, Chi T, Chi M, Moley KH, TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin. Reprod Fertil Dev. 2014 Dec;27(1):31-9
1	J:341543 Meng TG, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH, Wang ZB, Wong CCL, Li Z, Sun QY, NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). 2023 Sep;10(27):e2301940
5	J:297088 Naito Y, Asada N, Nguyen MD, Sanada K, AMP-activated protein kinase regulates cytoplasmic dynein behavior and contributes to neuronal migration in the developing neocortex. Development. 2020 Jul 15;147(14):dev187310
1	J:333724 Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, Lee CW, Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
1	J:208504 Qiao L, Yoo HS, Madon A, Kinney B, Hay WW Jr, Shao J, Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012 Dec;61(12):3199-207
1	J:228258 Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, Tsuchihara K, Bungard D, Berger SL, Jones RG, Mak TW, Zaugg K, Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ. 2013 Apr;20(4):659-68
1	J:319888 Son JS, Chae SA, Zhao L, Wang H, de Avila JM, Zhu MJ, Jiang Z, Du M, Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. EBioMedicine. 2022 Jan 23;76:103842
6*	J:54164 Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE, Bartlett PF, Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
1*	J:305107 Ulisse V, Dey S, Rothbard DE, Zeevi E, Gokhman I, Dadosh T, Minis A, Yaron A, Regulation of axonal morphogenesis by the mitochondrial protein Efhd1. Life Sci Alliance. 2020 Jul;3(7)
2	J:239679 Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, Gonzalez-Billalabeitia E, Hung MC, Song SJ, Song MS, A UBE2O-AMPKalpha2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 Feb 13;31(2):208-224
2	J:328042 Wang T, Guo H, Li Q, Wu W, Yu M, Zhang L, Li C, Song J, Wang Z, Zhang J, Tang Y, Kang L, Zhang H, Zhan J, The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations. Cell Rep. 2022 Aug 23;40(8):111210
6	J:171212 Williams T, Courchet J, Viollet B, Brenman JE, Polleux F, AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5849-54
5*	J:305946 Xu M, Yao J, Shi Y, Yi H, Zhao W, Lin X, Yang Z, The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026
1*	J:254549 Xu Y, Gu Y, Liu G, Zhang F, Li J, Liu F, Zhang Z, Ye J, Li Q, Cidec promotes the differentiation of human adipocytes by degradation of AMPKalpha through ubiquitin-proteasome pathway. Biochim Biophys Acta. 2015 Dec;1850(12):2552-62
4	J:310904 Yashirogi S, Nagao T, Nishida Y, Takahashi Y, Qaqorh T, Yazawa I, Katayama T, Kioka H, Matsui TS, Saito S, Masumura Y, Tsukamoto O, Kato H, Ueda H, Yamaguchi O, Yashiro K, Yamazaki S, Takashima S, Shintani Y, AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170. EMBO Rep. 2021 Jan 7;22(1):e50949
1*	J:160941 Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS, The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 5;11(5):364-78
1	J:321836 Zhao K, Huang X, Zhao W, Lu B, Yang Z, LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. Development. 2022 Mar 15;149(6):dev200458
1*	J:324720 Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S, Wang Q, Sesaki H, Mitra K, Liu K, Jiao K, Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. J Cell Sci. 2022 Feb 15;135(4):jcs258956
2	J:163880 Zhou X, Anderson KV, Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism. Dev Biol. 2010 Aug 1;344(1):185-95
1	J:306153 Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988