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Gene Expression Literature Summary
Symbol
Name
ID
Dyrk1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
MGI:1330299

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18 E18.5 E19 E20 E A
In situ protein (section) 2 1 2 2 1 1 4
In situ RNA (section) 1 2 1 1 1 1 1 1 1 2 2 1 2 1 1 1 1 3
In situ RNA (whole mount) 1 2 1 2 3 1
Northern blot 2 2 2 2 1
Western blot 1 1 2 1 1 1 1 1 1 5
RT-PCR 1 1 1 2 1 1 1 1 1 6
cDNA clones 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Dyrk1a  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a   (Synonyms: 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh)
Results  Reference
2J:109139 Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR, NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006 Jun 1;441(7093):595-600
1*J:150493 Fernandez-Martinez J, Vela EM, Tora-Ponsioen M, Ocana OH, Nieto MA, Galceran J, Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A. J Cell Sci. 2009 May 15;122(Pt 10):1574-83
3J:164437 Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sanchez P, Arbones ML, Farinas I, Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell. 2010 Sep 3;7(3):367-79
7*J:67406 Geiger JN, Knudsen GT, Panek L, Pandit AK, Yoder MD, Lord KA, Creasy CL, Burns BM, Gaines P, Dillon SB, Wojchowski DM, mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Blood. 2001 Feb 15;97(4):901-10
3*J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
2J:182294 Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM, DYRK1A: A master regulatory protein controlling brain growth. Neurobiol Dis. 2012 Apr;46(1):190-203
20J:133208 Hammerle B, Elizalde C, Tejedor FJ, The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development. Eur J Neurosci. 2008 Mar;27(5):1061-74
4J:77263 Hammerle B, Vera-Samper E, Speicher S, Arencibia R, Martinez S, Tejedor FJ, Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions. Dev Biol. 2002 Jun 15;246(2):259-73
3*J:112895 Kim MY, Jeong BC, Lee JH, Kee HJ, Kook H, Kim NS, Kim YH, Kim JK, Ahn KY, Kim KK, A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13074-9
3J:205486 Kurabayashi N, Sanada K, Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013 Dec 15;27(24):2708-21
5J:144220 Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernandez E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbones ML, The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell. 2008 Dec;15(6):841-53
5J:146836 Lepagnol-Bestel AM, Zvara A, Maussion G, Quignon F, Ngimbous B, Ramoz N, Imbeaud S, Loe-Mie Y, Benihoud K, Agier N, Salin PA, Cardona A, Khung-Savatovsky S, Kallunki P, Delabar JM, Puskas LG, Delacroix H, Aggerbeck L, Delezoide AL, Delattre O, Gorwood P,Moalic JM, Simonneau M, DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome. Hum Mol Genet. 2009 Apr 15;18(8):1405-14
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2J:166796 Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC, Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010 Oct 8;285(41):31895-906
4J:51574 Rahmani Z, Lopes C, Rachidi M, Delabar JM, Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues. Biochem Biophys Res Commun. 1998 Dec 18;253(2):514-8
7*J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
14*J:37711 Song WJ, Sternberg LR, Kasten-Sportes C, Keuren ML, Chung SH, Slack AC, Miller DE, Glover TW, Chiang PW, Lou L, Kurnit DM, Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome critical region. Genomics. 1996 Dec 15;38(3):331-9
1J:162596 Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J, TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010 Apr 30;285(18):13721-35

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory