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Gene Expression Literature Summary
Symbol
Name
ID
Dlg4
discs, large homolog 4 (Drosophila)
MGI:1277959

57 matching records from 57 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8.5 E9.5 E10.5 E11.5 E13.5 E14.5 E15 E15.5 E16 E16.5 E17.5 E18 E18.5 E19.5 E A
In situ protein (section) 1 1 1 1 1 16
In situ RNA (section) 1 1 1 2 1 4
In situ protein (whole mount) 1 1
In situ RNA (whole mount) 1
In situ reporter (knock in) 1 1 1 1 1 1
Western blot 1 1 1 1 1 2 2 3 26
RT-PCR 1 1 1 1 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Dlg4  discs, large homolog 4 (Drosophila)   (Synonyms: Dlgh4, PSD95, PSD-95, SAP90, SAP90A)
Results  Reference
1J:146779 Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Muller U, Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4507-12
1*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1J:89658 Bolis A, Corbetta S, Cioce A, de Curtis I, Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci. 2003 Nov;18(9):2417-24
1*J:91381 Bouwman J, Maia AS, Camoletto PG, Posthuma G, Roubos EW, Oorschot VM, Klumperman J, Verhage M, Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience. 2004;126(1):115-26
1J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
2J:127045 Chakrabarti L, Galdzicki Z, Haydar TF, Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci. 2007 Oct 24;27(43):11483-95
1J:176125 Chalazonitis A, Tang AA, Shang Y, Pham TD, Hsieh I, Setlik W, Gershon MD, Huang EJ, Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopaminergic Neurons and Glia via BMP Signaling. J Neurosci. 2011 Sep 28;31(39):13746-57
1J:172355 Chen CY, Lin CW, Chang CY, Jiang ST, Hsueh YP, Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol. 2011 May 16;193(4):769-84
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:110865 Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA, Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol. 2006;4:14
4J:54783 Fukaya M, Ueda H, Yamauchi K, Inoue Y, Watanabe M, Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90 protein family in the mouse brain. Neurosci Res. 1999 Feb;33(2):111-8
1J:204665 Goldman JS, Ashour MA, Magdesian MH, Tritsch NX, Harris SN, Christofi N, Chemali R, Stern YE, Thompson-Steckel G, Gris P, Glasgow SD, Grutter P, Bouchard JF, Ruthazer ES, Stellwagen D, Kennedy TE, Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly. J Neurosci. 2013 Oct 30;33(44):17278-89
1J:136920 Hasegawa S, Hamada S, Kumode Y, Esumi S, Katori S, Fukuda E, Uchiyama Y, Hirabayashi T, Mombaerts P, Yagi T, The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. Mol Cell Neurosci. 2008 May;38(1):66-79
1*J:132626 Hayashi T, Okabe T, Nasu-Nishimura Y, Sakaue F, Ohwada S, Matsuura K, Akiyama T, Nakamura T, PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells. 2007 Aug;12(8):929-39
2J:154018 Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T, Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95. J Biol Chem. 2001 Mar 23;276(12):9174-81
1J:131843 Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N, Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1710-5
1*J:132267 Junghans D, Heidenreich M, Hack I, Taylor V, Frotscher M, Kemler R, Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Eur J Neurosci. 2008 Feb;27(3):559-71
2J:58210 Kneussel M, Brandstatter JH, Laube B, Stahl S, Muller U, Betz H, Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. J Neurosci. 1999 Nov 1;19(21):9289-97
1J:123312 Kurumada S, Onishi A, Imai H, Ishii K, Kobayashi T, Sato SB, Stage-specific association of apolipoprotein A-I and E in developing mouse retina. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1815-23
3J:207976 Li Q, Zheng S, Han A, Lin CH, Stoilov P, Fu XD, Black DL, The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
1*J:116509 Liu H, Nakazawa T, Tezuka T, Yamamoto T, Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. J Biol Chem. 2006 Aug 18;281(33):23611-9
1J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1J:184717 Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R, Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol. 2012 Mar;10(3):e1001283
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:98185 Matsuya S, Sakagami H, Tohgo A, Owada Y, Shin HW, Takeshima H, Nakayama K, Kokubun S, Kondo H, Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells. J Neurochem. 2005 May;93(3):674-85
1J:160811 McDowell KA, Hutchinson AN, Wong-Goodrich SJ, Presby MM, Su D, Rodriguiz RM, Law KC, Williams CL, Wetsel WC, West AE, Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010 Jun 2;30(22):7453-65
1J:159572 Medrihan L, Rohlmann A, Fairless R, Andrae J, Doring M, Missler M, Zhang W, Kilimann MW, Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol. 2009 Nov 1;587(Pt 21):5095-106
1J:109570 Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M, Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J Neurochem. 2006 Jun;97(5):1431-46
1J:98227 Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N, Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci. 2005 Feb 16;25(7):1826-35
1J:186644 Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP, Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via beta-Catenin. Mol Cell Biol. 2012 Aug;32(15):2966-78
4J:178882 Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P, Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18;21(4):655-68
1J:102649 Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS, Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005 Sep 26;170(7):1127-34
1J:84539 Peng XR, Jia Z, Zhang Y, Ware J, Trimble WS, The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol. 2002 Jan;22(1):378-87
1J:161516 Poore CP, Sundaram JR, Pareek TK, Fu A, Amin N, Mohamed NE, Zheng YL, Goh AX, Lai MK, Ip NY, Pant HC, Kesavapany S, Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity. J Neurosci. 2010 Jun 23;30(25):8457-67
6J:97490 Porter K, Komiyama NH, Vitalis T, Kind PC, Grant SG, Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development. Eur J Neurosci. 2005 Jan;21(2):351-62
1J:142349 Prasad T, Wang X, Gray PA, Weiner JA, A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster. Development. 2008 Dec;135(24):4153-64
1J:198564 Prince JE, Brignall AC, Cutforth T, Shen K, Cloutier JF, Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Development. 2013 Jun;140(11):2398-408
2J:172347 Saura CA, Servian-Morilla E, Scholl FG, Presenilin/gamma-Secretase Regulates Neurexin Processing at Synapses. PLoS One. 2011;6(4):e19430
1J:148808 Sawallisch C, Berhorster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp HJ, The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem. 2009 Apr 3;284(14):9225-36
1J:119934 Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Sudhof TC, Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J. 2006 Dec 13;25(24):5852-63
1J:163183 Scholz R, Berberich S, Rathgeber L, Kolleker A, Kohr G, Kornau HC, AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression. Neuron. 2010 Jun 10;66(5):768-80
1*J:159888 Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P rd, Herz J, Yu G, TDP-43 is a developmentally regulated protein essential for early embryonic development. J Biol Chem. 2010 Feb 26;285(9):6826-34
2*J:52209 Serpinskaya AS, Feng GP, Sanes JR, Craig AM, Synapse formation by hippocampal neurons from agrin- deficient mice. Dev Biol. 1999 JAN 1;205(1):65-78
2J:164650 Shiina N, Yamaguchi K, Tokunaga M, RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks. J Neurosci. 2010 Sep 22;30(38):12816-30
1J:57662 Shiraishi Y, Mizutani A, Bito H, Fujisawa K, Narumiya S, Mikoshiba K, Furuichi T, Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J Neurosci. 1999 Oct 1;19(19):8389-400
1J:106962 Son GH, Geum D, Chung S, Kim EJ, Jo JH, Kim CM, Lee KH, Kim H, Choi S, Kim HT, Lee CJ, Kim K, Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity. J Neurosci. 2006 Mar 22;26(12):3309-18
2J:89027 Tomoda T, Kim JH, Zhan C, Hatten ME, Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev. 2004 Mar 1;18(5):541-58
6J:178643 Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing M, Lickert H, Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell. 2011 Sep 13;21(3):479-91
1J:184403 Vasiljevic M, Heisler FF, Hausrat TJ, Fehr S, Milenkovic I, Kneussel M, Sieghart W, Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain. Neuroscience. 2012 Jan 27;202:29-41
2*J:140353 Vetrivel KS, Kodam A, Gong P, Chen Y, Parent AT, Kar S, Thinakaran G, Localization and regional distribution of p23/TMP21 in the brain. Neurobiol Dis. 2008 Oct;32(1):37-49
1J:67326 Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P, Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci. 2001 Jan;17(1):151-66
1J:158757 von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H, CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science. 2010 Mar 19;327(5972):1518-22
1J:205336 Waga C, Asano H, Sanagi T, Suzuki E, Nakamura Y, Tsuchiya A, Itoh M, Goto Y, Kohsaka S, Uchino S, Identification of two novel Shank3 transcripts in the developing mouse neocortex. J Neurochem. 2014 Jan;128(2):280-93
2J:107735 Wang X, Weiner JA, Levi S, Craig AM, Bradley A, Sanes JR, Gamma protocadherins are required for survival of spinal interneurons. Neuron. 2002 Dec 5;36(5):843-54
1J:93205 Weiner JA, Koo SJ, Nicolas S, Fraboulet S, Pfaff SL, Pourquie O, Sanes JR, Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci. 2004 Sep;27(1):59-69
1J:207904 Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV, A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2013;2:e01341
1J:136961 Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE, Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72

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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory