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Gene Expression Literature Summary
Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583

57 matching records from 57 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E6.5 E7 E7.5 E8 E9 E9.5 E10 E10.5 E11 E11.5 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 2 1 1 1 1 2 1 2 1 1 2 2 6 7 1 3 1 6 13
In situ RNA (section) 1 1 1 1 1 2 1 1 1 2
In situ RNA (whole mount) 1 1 1 1
Northern blot 2 2 2 2 1
Western blot 1 1 1 3 1 1 1 1 1 2 14
RT-PCR 1 1 1 1 2 1 6 1 2 3 3 11
cDNA clones 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pten  phosphatase and tensin homolog   (Synonyms: 2310035O07Rik, A130070J02Rik, B430203M17Rik, MMAC1, TEP1)
Results  Reference
1J:183946 Bloomekatz J, Grego-Bessa J, Migeotte I, Anderson KV, Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol. 2012 Apr 15;364(2):192-201
5J:154797 Cho KW, Cai J, Kim HY, Hosoya A, Ohshima H, Choi KY, Jung HS, ERK activation is involved in tooth development via FGF10 signaling. J Exp Zool B Mol Dev Evol. 2009 Dec 15;312(8):901-11
4*J:131397 Cho KW, Cho SW, Lee JM, Lee MJ, Gang HS, Jung HS, Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development. Gene Expr Patterns. 2008 Apr;8(4):284-290
6J:186116 Church DN, Phillips BR, Stuckey DJ, Barnes DJ, Buffa FM, Manek S, Clarke K, Harris AL, Carter EJ, Hassan AB, Igf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouse. Oncogene. 2012 Aug 2;31(31):3635-46
4J:178952 Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM, Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell. 2011 Nov 15;20(5):635-48
5J:166789 Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Suzuki A, Holley MC, Tokuda M, Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea. Neuroscience. 2010 Nov 10;170(4):1304-13
6J:190411 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY, Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem. 2012 Sep 14;287(38):32172-9
1J:139945 El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, Mishina Y, Rabinovitch M, SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development. 2008 Sep;135(17):2981-91
2J:132648 Escriva M, Peiro S, Herranz N, Villagrasa P, Dave N, Montserrat-Sentis B, Murray SA, Franci C, Gridley T, Virtanen I, Garcia de Herreros A, Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol. 2008 Mar;28(5):1528-40
1J:139818 Feutz AC, Barrandon Y, Monard D, Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J Cell Sci. 2008 May 1;121(Pt 9):1435-43
1J:149918 Fuchs S, Herzog D, Sumara G, Buchmann-Moller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L, Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell. 2009 Mar 6;4(3):236-47
3J:186096 Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP, Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30;149(1):49-62
1J:180109 Guntur AR, Rosen CJ, Naski MC, N-cadherin adherens junctions mediate osteogenesis through PI3K signaling. Bone. 2012 Jan;50(1):54-62
1J:100493 Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A, The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 2005 Sep 1;19(17):2054-65
1J:152840 Hou SC, Chan LW, Chou YC, Su CY, Chen X, Shih YL, Tsai PC, Shen CK, Yan YT, Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Lett. 2009 Sep 3;583(17):2765-71
1J:157570 Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z, Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
1J:171508 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N, Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
3J:181926 Jo HS, Kang KH, Joe CO, Kim JW, Pten coordinates retinal neurogenesis by regulating Notch signalling. EMBO J. 2012 Feb 15;31(4):817-28
7J:197212 Kim HJ, Woo HM, Ryu J, Bok J, Kim JW, Choi SB, Park MH, Park HY, Koo SK, Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS One. 2013;8(2):e55609
1J:82464 Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, Nakano T, Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development. 2003 Apr;130(8):1691-700
1J:173348 Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H, Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9472-7
1J:156489 Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D, The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22323-8
4J:170203 Lague MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D, Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E936-46
1J:153553 Li C, Li A, Li M, Xing Y, Chen H, Hu L, Tiozzo C, Anderson S, Taketo MM, Minoo P, Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis. Dev Biol. 2009 Oct 1;334(1):97-108
1J:130044 Li W, Sun G, Yang S, Qu Q, Nakashima K, Shi Y, Nuclear Receptor TLX Regulates Cell Cycle Progression in Neural Stem Cells of the Developing Brain. Mol Endocrinol. 2008 Jan;22(1):56-64
1J:201649 Li Y, Liu J, McLaughlin N, Bachvarov D, Saifudeen Z, El-Dahr SS, Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney. Physiol Genomics. 2013 Oct 16;45(20):948-64
1J:161852 Libusova L, Stemmler MP, Hierholzer A, Schwarz H, Kemler R, N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation. Development. 2010 Jul;137(14):2297-305
1J:149829 Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G, Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech. 2009 Jul-Aug;2(7-8):389-98
6*J:56026 Luukko K, Ylikorkala A, Tiainen M, Makela TP, Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev. 1999 May;83(1-2):187-90
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2J:144068 Nishino J, Kim I, Chada K, Morrison SJ, Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell. 2008 Oct 17;135(2):227-39
1J:112269 Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K, Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development. 2006 Sep;133(17):3473-84
1J:166796 Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC, Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010 Oct 8;285(41):31895-906
1J:141066 Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z, Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 7;322(5903):963-6
12J:53065 Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM , Cordon-Cardo C , Catoretti G , Fisher PE , Parsons R, Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8
1J:149326 Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ, A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet. 2009 Jul 1;18(13):2378-87
1*J:92177 Powles N, Babbs C, Ficker M, Schimmang T, Maconochie M, Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Dev Biol. 2004 Apr 1;268(1):24-38
5J:155110 Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L, Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. J Clin Invest. 2009 Dec;119(12):3586-96
1*J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
2J:158619 Small EM, O'Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD, Richardson JA, Olson EN, Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4218-23
2J:39352 Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV, Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997 Apr;15(4):356-62
2J:106937 Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H, Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr;26(7):2772-81
6J:50437 Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I , Ho A , Wakeham A , Itie A , Khoo W , Fukumoto M , Mak TW, High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol. 1998 Oct 22;8(21):1169-78
1J:164696 Tan Y, You H, Coffey FJ, Wiest DL, Testa JR, Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis. 2010 Sep;48(9):531-9
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1J:171513 Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE, Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011 Apr;138(7):1235-45
3J:192736 Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P, Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1;122(11):3862-72
2J:197590 Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Rehan V, De Langhe S, Di Cristofano A, Bellusci S, Minoo P, Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr;19(2):111-22
2J:167962 Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P, Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15;180(8):701-12
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3J:158751 Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G, Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
4*J:65653 Wertz K, Herrmann BG, Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
2J:175387 Wu X, Xu K, Zhang L, Deng Y, Lee P, Shapiro E, Monaco M, Makarenkova HP, Li J, Lepor H, Grishina I, Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism. Dev Biol. 2011 Aug 15;356(2):337-49
1J:157922 Xing Y, Li C, Li A, Sridurongrit S, Tiozzo C, Bellusci S, Borok Z, Kaartinen V, Minoo P, Signaling via Alk5 controls the ontogeny of lung Clara cells. Development. 2010 Mar;137(5):825-33
2*J:97770 Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G, Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005 Mar 11;280(10):9330-5
4J:108702 Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM, Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15;20(10):1308-20
3J:137701 Zhang H, Liu R, Wang R, Hong S, Xu H, Zhang YW, Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiol Aging. 2008 May;29(5):653-60

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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory