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Gene Expression Literature Summary
Symbol
Name
ID
Adam10
a disintegrin and metallopeptidase domain 10
MGI:109548

21 matching records from 21 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E9.5 E10 E10.5 E11.5 E12.5 E13 E13.5 E14.5 E15 E15.5 E16.5 E17 E17.5 E18 E18.5 E P
Immunohistochemistry (section) 1 1 1 1 1 3 1 3 3
In situ RNA (section) 1 1 1 1 4 1 1 3
In situ RNA (whole mount) 1 1
Northern blot 1 1
Western blot 1 1 1 1 1 1 3
RT-PCR 2 1 1 1 1 3
cDNA clones 1 1
RNase protection 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Adam10  a disintegrin and metallopeptidase domain 10   (Synonyms: 1700031C13Rik, kuz, kuzbanian)
Results  Reference
11*J:97065 Asayesh A, Alanentalo T, Khoo NK, Ahlgren U, Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments. Dev Dyn. 2005 Apr;232(4):1105-14
1J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:172287 Esteve P, Sandonis A, Cardozo M, Malapeira J, Ibanez C, Crespo I, Marcos S, Gonzalez-Garcia S, Toribio ML, Arribas J, Shimono A, Guerrero I, Bovolenta P, SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. Nat Neurosci. 2011 May;14(5):562-9
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1J:64122 Hattori M, Osterfield M, Flanagan JG, Regulated cleavage of a contact-mediated axon repellent [see comments] [comment]. Science. 2000 Aug 25;289(5483):1360-5
3J:95006 Kalinichenko VV, Gusarova GA, Kim IM, Shin B, Yoder HM, Clark J, Sapozhnikov AM, Whitsett JA, Costa RH, Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L521-30
1J:230682 Lucitti JL, Tarte NJ, Faber JE, Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation. Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1141-50
3J:65205 Marcinkiewicz M, Seidah NG, Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J Neurochem. 2000 Nov;75(5):2133-43
2J:220152 Marcos S, Nieto-Lopez F, Sandonis A, Cardozo MJ, Di Marco F, Esteve P, Bovolenta P, Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. J Neurosci. 2015 Mar 18;35(11):4729-40
1J:99872 Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P, ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7
1J:160358 Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H, MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010 Jun 1;24(11):1173-85
1J:150963 Pavlinkova G, Salbaum JM, Kappen C, Maternal diabetes alters transcriptional programs in the developing embryo. BMC Genomics. 2009;10:274
1J:203162 Ray A, Treloar HB, IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol Cell Neurosci. 2012 Jul;50(3-4):238-49
4J:235953 Tan Y, Fu R, Liu J, Wu Y, Wang B, Jiang N, Nie P, Cao H, Yang Z, Fang B, ADAM10 is essential for cranial neural crest-derived maxillofacial bone development. Biochem Biophys Res Commun. 2016 Jul 8;475(4):308-14
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2*J:149783 Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B, ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem. 2009 Apr 24;284(17):11738-47
4J:170542 Weber S, Niessen MT, Prox J, Lullmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P, The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development. 2011 Feb;138(3):495-505
7J:48434 Yavari R, Adida C, Bray-Ward P, Brines M, Xu T, Human metalloprotease-disintegrin Kuzbanian regulates sympathoadrenal cell fate in development and neoplasia. Hum Mol Genet. 1998 Jul;7(7):1161-7
1J:203838 Yoon S, Baik JH, Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation. J Biol Chem. 2013 Oct 4;288(40):28435-46
1J:164023 Zhang C, Tian L, Chi C, Wu X, Yang X, Han M, Xu T, Zhuang Y, Deng K, Adam10 is essential for early embryonic cardiovascular development. Dev Dyn. 2010 Oct;239(10):2594-602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/16/2019
MGI 6.14
The Jackson Laboratory