Gene Expression Literature Summary

• Symbol: Htr2a
• Name: 5-hydroxytryptamine (serotonin) receptor 2A
• ID: MGI:109521

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E8.5	E9	E10	E10.5	E11.5	E12.5	E13	E13.5	E15	E15.5	E16	E17.5	E18.5	P
Immunohistochemistry (section)		1	1	1	2	3	1		3		1		1		1
In situ RNA (section)						2			1		2			1	3
Western blot														1
RT-PCR	1		1	1	1			1	1	1	1	2	1	1	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Htr2a  5-hydroxytryptamine (serotonin) receptor 2A   (Synonyms: 5-HT2A receptor, Htr2, Htr-2)
Results	Reference
1	J:69975 Cai J, Qi Y, Wu R, Modderman G, Fu H, Liu R, Qiu M, Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally. Mol Cell Biol. 2001 Jul;21(13):4399-403
4*	J:40606 Choi DS, Ward SJ, Messaddeq N, Launay JM, Maroteaux L, 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development. 1997 May;124(9):1745-55
2	J:59184 Fiorica-Howells E, Maroteaux L, Gershon MD, Serotonin and the 5-HT(2B) receptor in the development of enteric neurons. J Neurosci. 2000 Jan 1;20(1):294-305
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:113294 Hunt PN, Gust J, McCabe AK, Bosma MM, Primary role of the serotonergic midline system in synchronized spontaneous activity during development of the embryonic mouse hindbrain. J Neurobiol. 2006 Sep 15;66(11):1239-52
1	J:103008 Hunt PN, McCabe AK, Bosma MM, Midline serotonergic neurones contribute to widespread synchronized activity in embryonic mouse hindbrain. J Physiol. 2005 Aug 1;566(Pt 3):807-19
2*	J:45703 Kato MV, Ikawa Y, Hayashizaki Y, Shibata H, Paternal imprinting of mouse serotonin receptor 2A gene Htr2 in embryonic eye: a conserved imprinting regulation on the RB/Rb locus. Genomics. 1998 Jan 1;47(1):146-8
8*	J:74070 Lauder JM, Wilkie MB, Wu C, Singh S, Expression of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in the mouse embryo. Int J Dev Neurosci. 2000 Nov;18(7):653-62
1*	J:314358 Liu S, Kim DI, Oh TG, Pao GM, Kim JH, Palmiter RD, Banghart MR, Lee KF, Evans RM, Han S, Neural basis of opioid-induced respiratory depression and its rescue. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2022134118
3*	J:240101 Lv J, Wang L, Gao Y, Ding YQ, Liu F, 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3	J:284574 Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H, Serotonin Regulates Adult beta-Cell Mass by Stimulating Perinatal beta-Cell Proliferation. Diabetes. 2020 Feb;69(2):205-214
1	J:155633 Pavone LM, Spina A, Rea S, Santoro D, Mastellone V, Lombardi P, Avallone L, Serotonin transporter gene deficiency is associated with sudden death of newborn mice through activation of TGF-beta1 signalling. J Mol Cell Cardiol. 2009 Nov;47(5):691-7
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2*	J:300543 Xing L, Kalebic N, Namba T, Vaid S, Wimberger P, Huttner WB, Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex. Neuron. 2020 Dec 23;108(6):1113-1129.e6
1	J:240993 Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G, A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009 Sep 04;138(5):976-89
1	J:295435 Yli-Karjanmaa M, Larsen KS, Fenger CD, Kristensen LK, Martin NA, Jensen PT, Breton A, Nathanson L, Nielsen PV, Lund MC, Carlsen SL, Gramsbergen JB, Finsen B, Stubbe J, Frich LH, Stolp H, Brambilla R, Anthony DC, Meyer M, Lambertsen KL, TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain Behav Immun. 2019 Nov;82:279-297