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Gene Expression Literature Summary
Symbol
Name
ID
Kcnq1
potassium voltage-gated channel, subfamily Q, member 1
MGI:108083

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E3.5 E4 E6.5 E7.5 E8.5 E9.5 E10.5 E11.5 E12.5 E13.5 E14.5 E15 E15.5 E16.5 E17 E17.5 E18 E18.5 E19.5 E A
In situ protein (section) 2 2 1 1 2 1 2 1 1 1 1 6
In situ RNA (section) 1 1 1 1 4
In situ RNA (whole mount) 1 1 1 1 1
Northern blot 1 2 1 1 1
Western blot 1
RT-PCR 1 1 2 2 3 6 4 3 4 7 2 1 3 2 1 2 2 1 1 24
RNase protection 2
Primer Extension 2 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Kcnq1  potassium voltage-gated channel, subfamily Q, member 1   (Synonyms: Kcna9, KVLQT1)
Results  Reference
4J:10529 Bastian H, Gruss P, A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
1J:197180 Buniello A, Hardisty-Hughes RE, Pass JC, Bober E, Smith RJ, Steel KP, Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One. 2013;8(2):e56274
7*J:47668 Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM, Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol Cell Biol. 1998 Jun;18(6):3466-74
2*J:96366 Cerrato F, Sparago A, Di Matteo I, Zou X, Dean W, Sasaki H, Smith P, Genesio R, Bruggemann M, Reik W, Riccio A, The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Hum Mol Genet. 2005 Feb 15;14(4):503-11
1J:143477 Chotalia M, Smallwood SA, Ruf N, Dawson C, Lucifero D, Frontera M, James K, Dean W, Kelsey G, Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev. 2009 Jan 1;23(1):105-17
2*J:56342 Dao D, Walsh CP, Yuan L, Gorelov D, Feng L, Hensle T, Nisen P, Yamashiro DJ, Bestor TH, Tycko B, Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Hum Mol Genet. 1999 Jul;8(7):1337-52
5J:174181 de Castro MP, Aranega A, Franco D, Protein distribution of Kcnq1, Kcnh2, and Kcne3 potassium channel subunits during mouse embryonic development. Anat Rec A Discov Mol Cell Evol Biol. 2006 Mar;288(3):304-15
6J:68046 Demolombe S, Franco D, de Boer P, Kuperschmidt S, Roden D, Pereon Y, Jarry A, Moorman AF, Escande D, Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol. 2001 Feb;280(2):C359-72
5J:79882 Fitzpatrick GV, Soloway PD, Higgins MJ, Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 2002 Nov;32(3):426-31
13J:74171 Franco D, Demolombe S, Kupershmidt S, Dumaine R, Dominguez JN, Roden D, Antzelevitch C, Escande D, Moorman AF, Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development. Cardiovasc Res. 2001 Oct;52(1):65-75
9*J:46363 Gould TD, Pfeifer K, Imprinting of mouse Kvlqt1 is developmentally regulated. Hum Mol Genet. 1998 Mar;7(3):483-7
1*J:118209 Green K, Lewis A, Dawson C, Dean W, Reinhart B, Chaillet JR, Reik W, A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm Genome. 2007 Jan;18(1):32-42
2*J:119550 Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1J:173801 Hudson QJ, Seidl CI, Kulinski TM, Huang R, Warczok KE, Bittner R, Bartolomei MS, Barlow DP, Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo. Dev Biol. 2011 May 15;353(2):420-31
3*J:50953 Jiang S, Hemann MA, Lee MP, Feinberg AP, Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1. Genomics. 1998 Nov 1;53(3):395-9
2J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
4J:108906 Koay G, Heffner R, Heffner H, Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls. Hear Res. 2002 Sep;171(1-2):111-118
7J:190449 Korostowski L, Sedlak N, Engel N, The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart. PLoS Genet. 2012 Sep;8(9):e1002956
1J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26
2J:114401 Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W, Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006 Nov;133(21):4203-10
2J:94246 Lewis A, Mitsuya K, Umlauf D, Smith P, Dean W, Walter J, Higgins M, Feil R, Reik W, Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet. 2004 Dec;36(12):1291-5
5J:200823 Li X, Zhou F, Marcus DC, Wangemann P, Endolymphatic Na(+) and K(+) concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin. PLoS One. 2013;8(5):e65977
2J:82790 Mager J, Montgomery ND, de Villena FP, Magnuson T, Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003 Apr;33(4):502-7
2*J:91511 Mai W, Janier MF, Allioli N, Quignodon L, Chuzel T, Flamant F, Samarut J, Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10332-7
3J:108700 Mancini-Dinardo D, Steele SJ, Levorse JM, Ingram RS, Tilghman SM, Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82
3J:163857 Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C, Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development. 2010 Aug 1;137(15):2493-9
1J:77375 Nguyen-Tran VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR, A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 2000 Sep 1;102(5):671-82
4J:108905 Nicolas M, Dememes D, Martin A, Kupershmidt S, Barhanin J, KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells. Hear Res. 2001 Mar;153(1-2):132-45
2J:161410 Oh-McGinnis R, Bogutz AB, Lee KY, Higgins MJ, Lefebvre L, Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol. 2010;10:50
2*J:48435 Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies KE, Hu RJ, Feinberg AP, Maher ER, Reik W, Walter J, Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. Hum Mol Genet. 1998 Jul;7(7):1149-59
2J:144190 Redrup L, Branco MR, Perdeaux ER, Krueger C, Lewis A, Santos F, Nagano T, Cobb BS, Fraser P, Reik W, The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development. 2009 Feb;136(4):525-30
2J:178399 Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW, KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec;25(12):4264-73
2J:130529 Shin JY, Fitzpatrick GV, Higgins MJ, Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J. 2008 Jan 9;27(1):168-78
1J:189624 Son EJ, Wu L, Yoon H, Kim S, Choi JY, Bok J, Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
1J:178162 Trowe MO, Maier H, Petry M, Schweizer M, Schuster-Gossler K, Kispert A, Impaired stria vascularis integrity upon loss of E-cadherin in basal cells. Dev Biol. 2011 Nov 1;359(1):95-107
1J:134489 Trowe MO, Maier H, Schweizer M, Kispert A, Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes. Development. 2008 May;135(9):1725-34
4*J:94241 Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R, Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet. 2004 Dec;36(12):1296-300
2J:160540 Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF, Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9753-8

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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory