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Gene Expression Literature Summary
Symbol
Name
ID
Tubb4a
tubulin, beta 4A class IVA
MGI:107848

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8 E8.5 E10 E10.5 E12.5 E14 E14.5 E15 E15.5 E16 E16.5 E17.5 E18 E18.5 E19.5 E P
Immunohistochemistry (section) 3 2 3 2 2 16 1 2 11
In situ RNA (section) 2
In situ RNA (whole mount) 1 1
Northern blot 1 1 1 1 1
RT-PCR 1 2 1 1 1 1 2 4 7
cDNA clones 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tubb4a  tubulin, beta 4A class IVA   (Synonyms: Tubb, Tubb4)
Results  Reference
1J:251794 Antony N, McDougall AR, Mantamadiotis T, Cole TJ, Bird AD, Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms. Sci Rep. 2016 May 6;6:25569
5*J:147561 Blatt EN, Yan XH, Wuerffel MK, Hamilos DL, Brody SL, Forkhead transcription factor HFH-4 expression is temporally related to ciliogenesis. Am J Respir Cell Mol Biol. 1999 Aug;21(2):168-76
1J:185338 Boucherat O, Chakir J, Jeannotte L, The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways. Biol Open. 2012;q:677-691
6*J:196330 Breuss M, Heng JI, Poirier K, Tian G, Jaglin XH, Qu Z, Braun A, Gstrein T, Ngo L, Haas M, Bahi-Buisson N, Moutard ML, Passemard S, Verloes A, Gressens P, Xie Y, Robson KJ, Rani DS, Thangaraj K, Clausen T, Chelly J, Cowan NJ, Keays DA, Mutations in the beta-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. Cell Rep. 2012 Dec 27;2(6):1554-62
1J:24904 Christofori G, Naik P, Hanahan D, Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis. Nat Genet. 1995 Jun;10(2):196-201
3J:63257 Crisera CA, Maldonado TS, Kadison AS, Li M, Alkasab SL, Longaker MT, Gittes GK, Transforming growth factor-beta 1 in the developing mouse pancreas: a potential regulator of exocrine differentiation. Differentiation. 2000 May;65(5):255-9
2J:95347 Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM, Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol. 2004 Jul;287(1):C171-81
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
1J:87186 Huang T, You Y, Spoor MS, Richer EJ, Kudva VV, Paige RC, Seiler MP, Liebler JM, Zabner J, Plopper CG, Brody SL, Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci. 2003 Dec 15;116(Pt 24):4935-45
1J:198291 Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ, Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
3J:195630 Krolewski RC, Packard A, Jang W, Wildner H, Schwob JE, Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One. 2012;7(12):e51737
1J:245768 Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L, HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 01;144(19):3547-3561
1J:270401 Latremoliere A, Cheng L, DeLisle M, Wu C, Chew S, Hutchinson EB, Sheridan A, Alexandre C, Latremoliere F, Sheu SH, Golidy S, Omura T, Huebner EA, Fan Y, Whitman MC, Nguyen E, Hermawan C, Pierpaoli C, Tischfield MA, Woolf CJ, Engle EC, Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration. Cell Rep. 2018 Aug 14;24(7):1865-1879.e9
7*J:19085 Lewis SA, Lee MG, Cowan NJ, Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985 Sep;101(3):852-61
1J:162871 Li A, Xing Y, Chan B, Heisterkamp N, Groffen J, Borok Z, Minoo P, Li C, Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010 Aug;239(8):2288-97
1J:198191 Li C, Li A, Xing Y, Li M, Chan B, Ouyang R, Taketo MM, Kucherlapati R, Borok Z, Minoo P, Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1;378(1):13-24
1J:234990 Li S, Morley M, Lu M, Zhou S, Stewart K, French CA, Tucker HO, Fisher SE, Morrisey EE, Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development. Dev Biol. 2016 Aug 15;416(2):338-46
2J:185603 Li S, Wang Y, Zhang Y, Lu MM, Demayo FJ, Dekker JD, Tucker PW, Morrisey EE, Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul;139(14):2500-9
4J:195172 Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A, Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet. 2013 Jan;9(1):e1003189
1J:73657 Miller LA, Wert SE, Whitsett JA, Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J Histochem Cytochem. 2001 Dec;49(12):1593-604
1J:238903 Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV, Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15;142(2):258-67
1J:109303 Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA, Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol. 2006 Jun 1;294(1):192-202
1J:24332 Reginelli AD, Wang YQ, Sassoon D, Muneoka K, Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development. 1995 Apr;121(4):1065-76
1*J:138696 Sato A, Sekine Y, Saruta C, Nishibe H, Morita N, Sato Y, Sadakata T, Shinoda Y, Kojima T, Furuichi T, Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. Neural Netw. 2008 Oct;21(8):1056-69
1J:121421 Shu W, Lu MM, Zhang Y, Tucker PW, Zhou D, Morrisey EE, Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development. 2007 May;134(10):1991-2000
3J:217677 Snitow ME, Li S, Morley MP, Rathi K, Lu MM, Kadzik RS, Stewart KM, Morrisey EE, Ezh2 represses the basal cell lineage during lung endoderm development. Development. 2015 Jan 1;142(1):108-17
1J:132011 Sun J, Chen H, Chen C, Whitsett JA, Mishina Y, Bringas P Jr, Ma JC, Warburton D, Shi W, Prenatal lung epithelial cell-specific abrogation of alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol. 2008 Mar;172(3):571-82
2*J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1J:115581 Tian J, Mahmood R, Hnasko R, Locker J, Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia. Cancer Res. 2006 Nov 1;66(21):10399-407
1*J:57678 Tichelaar JW, Lim L, Costa RH, Whitsett JA, HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo. Dev Biol. 1999 Sep 15;213(2):405-17
3J:55155 Tichelaar JW, Wert SE, Costa RH, Kimura S, Whitsett JA, HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung. J Histochem Cytochem. 1999 Jun;47(6):823-32
2J:167962 Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P, Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15;180(8):701-12
1J:225175 Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D, Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013;11:117
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2J:233746 Wang X, Wang Y, Snitow ME, Stewart KM, Li S, Lu M, Morrisey EE, Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Dev Biol. 2016 Jun 15;414(2):161-9
2J:195044 Wang Y, Tian Y, Morley MP, Lu MM, Demayo FJ, Olson EN, Morrisey EE, Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
1J:169137 Xu B, Chen C, Chen H, Zheng SG, Bringas P Jr, Xu M, Zhou X, Chen D, Umans L, Zwijsen A, Shi W, Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development. 2011 Mar;138(5):925-35

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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory