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Gene Expression Literature Summary
Symbol
Name
ID
Tnf
tumor necrosis factor
MGI:104798

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E4 E4.5 E5.5 E6.5 E7.5 E8.5 E9.5 E10 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E20 E A
In situ protein (section) 1 1 1 1 1 3 1 5 1 1 1 1 2 1 1 4
In situ RNA (section) 2 2 2 1 1 1 2 3 1 1 1 1 2 1 1 1
In situ protein (whole mount) 1
Northern blot 2 1 2 2 1 2 1 1 2 1 1 2
Western blot 1 2 1 1
RT-PCR 2 1 1 2 1 1 1 1 5 2 4 2 4 1 3 4 1 4 1 2 18
RNase protection 2 2 2 4 2 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tnf  tumor necrosis factor   (Synonyms: DIF, Tnfa, TNFalpha, TNF alpha, TNF-alpha, Tnfsf1a, tumor necrosis factor-alpha)
Results  Reference
1*J:93240 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y, Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Dec 9;101(45):16016-21
1J:148493 Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, Dubus P, Hovnanian A, Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 2009 May 11;206(5):1135-47
1*J:180855 Briot A, Lacroix M, Robin A, Steinhoff M, Deraison C, Hovnanian A, Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol. 2010 Dec;130(12):2736-42
6*J:17727 Burns TM, Clough JA, Klein RM, Wood GW, Berman NE, Developmental regulation of cytokine expression in the mouse brain. Growth Factors. 1993;9(4):253-8
1J:67398 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ, The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001 Feb;158(2):469-79
7J:21326 Deman J, Humblet C, Martin MT, Boniver J, Defresne MP, Analysis by in situ hybridization of cytokine mRNA expression in the murine developing thymus. Int Immunol. 1994 Oct;6(10):1613-9
7J:35158 Deman J, Van Meurs M, Claassen E, Humblet C, Boniver J, Defresne MP, In vivo expression of interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6, tumour necrosis factor-alpha and interferon-gamma in the fetal murine thymus. Immunology. 1996 Sep;89(1):152-7
3J:53584 Doi TS, Marino MW, Takahashi T, Yoshida T, Sakakura T, Old LJ, Obata Y, Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2994-9
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1J:31226 Gerwin N, Jia GQ, Kulbacki R, Gutierrez-Ramos JC, Interleukin gene expression in mouse preimplantation development. Dev Immunol. 1995;4(3):169-79
1*J:40876 Haddad EK, Duclos AJ, Lapp WS, Baines MG, Early embryo loss is associated with the prior expression of macrophage activation markers in the decidua. J Immunol. 1997 May 15;158(10):4886-92
17J:14542 Hunt JS, Chen HL, Hu XL, Pollard JW, Normal distribution of tumor necrosis factor-alpha messenger ribonucleic acid and protein in the uteri, placentas, and embryos of osteopetrotic (op/op) mice lacking colony-stimulating factor-1. Biol Reprod. 1993 Sep;49(3):441-52
3J:52479 Ivnitsky I, Torchinsky A, Gorivodsky M, Zemliak I, Orenstein H, Savion S, Shepshelovich J, Carp H, Fein A, Toder V, TNF-alpha expression in embryos exposed to a teratogen. Am J Reprod Immunol. 1998 Dec;40(6):431-40
3J:176703 Jaiswal MK, Gilman-Sachs A, Chaouat G, Beaman KD, Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice. Biol Reprod. 2011 Sep;85(3):626-34
1J:185213 Jaiswal MK, Mallers TM, Larsen B, Kwak-Kim J, Chaouat G, Gilman-Sachs A, Beaman KD, V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy. Reproduction. 2012 May;143(5):713-25
6J:21013 Jaskoll T, Boyer PD, Melnick M, Tumor necrosis factor-alpha and embryonic mouse lung morphogenesis. Dev Dyn. 1994 OCT;201(2):137-150
1J:69420 Jaskoll T, Melnick M, Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 Nov 1;256(3):252-68
4J:84726 Joswig A, Gabriel HD, Kibschull M, Winterhager E, Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol. 2003 May 26;1(1):44
3J:137419 Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, Jobin C, Ninomiya-Tsuji J, Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol. 2008 Jul 15;181(2):1143-52
3*J:94930 Kamiya A, Gonzalez FJ, TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology. 2004 Sep;40(3):527-36
1J:130907 Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O'Connor CL, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ, A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. J Immunol. 2008 Jan 1;180(1):601-8
3J:170178 Kobayashi K, Umezawa K, Yasui M, Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biol Reprod. 2011 Feb;84(2):248-54
7*J:17723 Kohchi C, Noguchi K, Tanabe Y, Mizuno D, Soma G, Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development. Int J Biochem. 1994 Jan;26(1):111-9
1J:145398 Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG, Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1;110(3):870-6
3J:91786 Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL, Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem. 2004 Jul 30;279(31):32869-81
5J:67809 Melnick M, Chen H, Zhou Y, Jaskoll T, Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec. 2001 Mar 1;262(3):318-30
5J:68367 Melnick M, Chen H, Zhou YM, Jaskoll T, Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001;168(4):233-45
6J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
1J:144402 Miralles F, Hebrard S, Lamotte L, Durel B, Gilgenkrantz H, Li Z, Daegelen D, Tuil D, Joshi RL, Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis. Lab Invest. 2006 Oct;86(10):1020-36
7*J:44503 Montgomery RA, Dallman MJ, Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny. Cytokine. 1997 Oct;9(10):717-26
2J:194606 Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, Fukamizu A, Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice. Endocrinology. 2013 Feb;154(2):597-602
3*J:19108 Novack DV, Korsmeyer SJ, Bcl-2 protein expression during murine development [see comments]. Am J Pathol. 1994 Jul;145(1):61-73
1J:141401 Okabe Y, Kawane K, Nagata S, IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol. 2008 Nov;38(11):3150-8
1*J:143615 Orelio C, Haak E, Peeters M, Dzierzak E, Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo. Blood. 2008 Dec 15;112(13):4895-904
1J:90276 Ota MS, Loebel DA, O'Rourke MP, Wong N, Tsoi B, Tam PP, Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn. 2004 Jun;230(2):216-28
2J:22503 Rivera MT, Marques de Araujo S, Lucas R, Deman J, Truyens C, Defresne MP, de Baetselier P, Carlier Y, High tumor necrosis factor alpha (TNF-alpha) production in Trypanosoma cruzi-infected pregnant mice and increased TNF-alpha gene transcription in their offspring. Infect Immun. 1995 Feb;63(2):591-5
12J:28858 Roby KF, Laham N, Kroning H, Terranova PF, Hunt JS, Expression and localization of messenger RNA for tumor necrosis factor receptor (TNF-R) i and TNF-RII in pregnant mouse uterus and placenta. Endocrine. 1995 AUG;3(8):557-562
2J:60742 Rosenfeld ME, Prichard L, Shiojiri N, Fausto N, Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. Am J Pathol. 2000 Mar;156(3):997-1007
2J:135431 Salminen A, Paananen R, Vuolteenaho R, Metsola J, Ojaniemi M, Autio-Harmainen H, Hallman M, Maternal endotoxin-induced preterm birth in mice: fetal responses in toll-like receptors, collectins, and cytokines. Pediatr Res. 2008 Mar;63(3):280-6
3J:180111 Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M, Surfactant protein A modulates the lipopolysaccharide-induced inflammatory response related to preterm birth. Cytokine. 2011 Nov;56(2):442-9
1J:141141 Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ, Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest. 2008 Oct;118(10):3378-89
1J:148113 Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y, Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia. 2009 May;52(5):962-71
1J:193689 Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T, Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
1*J:64739 Wada R, Tifft CJ, Proia RL, Microglial activation precedes acute neurodegeneration in sandhoff disease and is suppressed by bone marrow transplantation. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10954-9
1J:94468 Wandzioch E, Kolterud A, Jacobsson M, Friedman SL, Carlsson L, Lhx2-/- mice develop liver fibrosis. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16549-54
1J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
1J:171395 Weaving L, Mihelec M, Storen R, Sosic D, Grigg JR, Tam PP, Jamieson RV, Twist2: role in corneal stromal keratocyte proliferation and corneal thickness. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5561-70
1J:168909 Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY, Dragon (repulsive guidance molecule B) inhibits IL-6 expression in macrophages. J Immunol. 2011 Feb 1;186(3):1369-76
1J:196696 Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML, The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 Apr 18;121(16):3228-36

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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory