Gene Expression Literature Summary

• Symbol: Twist2
• Name: twist basic helix-loop-helix transcription factor 2
• ID: MGI:104685

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)							2		1		1	1						1	1
In situ RNA (section)	1	3	4	2	8	1	6	2	6	1	5	4	1	3	1	4	1		3
Immunohistochemistry (whole mount)											1
In situ RNA (whole mount)	1	3	6		4		1		2		1	3
In situ reporter (knock in)			1																1
Northern blot									1										1
RT-PCR		3	1		1		1		3					2			2	1	2
cDNA clones									1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Twist2  twist basic helix-loop-helix transcription factor 2   (Synonyms: bHLHa39, Dermo1)
Results	Reference
1*	J:176660 Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM, A high-resolution molecular atlas of the fetal mouse lower urogenital tract. Dev Dyn. 2011 Oct;240(10):2364-77
5	J:326693 Angelozzi M, Pellegrino da Silva R, Gonzalez MV, Lefebvre V, Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep. 2022 Jul 12;40(2):111045
1	J:310136 Armfield BA, Cohn MJ, Single cell transcriptomic analysis of external genitalia reveals complex and sexually dimorphic cell populations in the early genital tubercle. Dev Biol. 2021 Sep;477:145-154
5	J:119323 Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA, Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol. 2006 Aug 1;296(1):164-76
2	J:90056 Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G, A twist code determines the onset of osteoblast differentiation. Dev Cell. 2004 Mar;6(3):423-35
1	J:297087 Bian Q, Cheng YH, Wilson JP, Su EY, Kim DW, Wang H, Yoo S, Blackshaw S, Cahan P, A single cell transcriptional atlas of early synovial joint development. Development. 2020 Jul 20;147(14):dev185777
4	J:236397 Bildsoe H, Fan X, Wilkie EE, Ashoti A, Jones VJ, Power M, Qin J, Wang J, Tam PP, Loebel DA, Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Dev Biol. 2016 Oct 1;418(1):189-203
1	J:150764 Bildsoe H, Loebel DA, Jones VJ, Chen YT, Behringer RR, Tam PP, Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009 Jul 15;331(2):176-88
1	J:175788 Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV, Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PLoS One. 2011;6(7):e22217
1	J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
1	J:229091 Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W, Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63
1*	J:65644 Buchner G, Broccoli V, Bulfone A, Orfanelli U, Gattuso C, Ballabio A, Franco B, MAEG, an EGF-repeat containing gene, is a new marker associated with dermatome specification and morphogenesis of its derivatives. Mech Dev. 2000 Nov;98(1-2):179-82
2	J:236321 Budnick I, Hamburg-Shields E, Chen D, Torre E, Jarrell A, Akhtar-Zaidi B, Cordovan O, Spitale RC, Scacheri P, Atit RP, Defining the identity of mouse embryonic dermal fibroblasts. Genesis. 2016 Aug;54(8):415-30
1	J:183485 Chen D, Jarrell A, Guo C, Lang R, Atit R, Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development. 2012 Apr;139(8):1522-33
1	J:42215 Dear TN, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, Boehm T, Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene. 1997 Feb 27;14(8):891-8
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:334108 Flynn CGK, Ginkel PRV, Hubert KA, Guo Q, Hrycaj SM, McDermott AE, Madruga A, Miller AP, Wellik DM, Hox11-expressing interstitial cells contribute to adult skeletal muscle at homeostasis. Development. 2023 Feb 15;150(4):dev201026
1	J:227703 Garside VC, Cullum R, Alder O, Lu DY, Vander Werff R, Bilenky M, Zhao Y, Jones SJ, Marra MA, Underhill TM, Hoodless PA, SOX9 modulates the expression of key transcription factors required for heart valve development. Development. 2015 Dec 15;142(24):4340-50
1	J:229313 Goodnough LH, Dinuoscio GJ, Atit RP, Twist1 contributes to cranial bone initiation and dermal condensation by maintaining wnt signaling responsiveness. Dev Dyn. 2016 Feb;245(2):144-56
4	J:226667 Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP, Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb;10(2):e1004152
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
5*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3*	J:61521 Houzelstein D, Cheraud Y, Auda-Boucher G, Fontaine-Perus J, Robert B, The expression of the homeobox gene Msx1 reveals two populations of dermal progenitor cells originating from the somites. Development. 2000 May;127(10):2155-64
1*	J:292270 Ideno H, Nakashima K, Komatsu K, Araki R, Abe M, Arai Y, Kimura H, Shinkai Y, Tachibana M, Nifuji A, G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development. Bone. 2020 Aug;137:115332
2*	J:274134 Javali A, Misra A, Leonavicius K, Acharyya D, Vyas B, Sambasivan R, Co-expression of Tbx6 and Sox2 identifies a novel transient neuromesoderm progenitor cell state. Development. 2017 Dec 15;144(24):4522-4529
1	J:106064 Kobielak A, Fuchs E, Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2322-7
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:234310 Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH, APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene. 2016 Apr 28;35(17):2223-34
15*	J:29655 Li L, Cserjesi P, Olson EN, Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev Biol. 1995 Nov;172(1):280-92
2	J:165329 Luna-Zurita L, Prados B, Grego-Bessa J, Luxan G, del Monte G, Benguria A, Adams RH, Perez-Pomares JM, de la Pompa JL, Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest. 2010 Oct 1;120(10):3493-507
3	J:266862 Morosan-Puopolo G, Balakrishnan-Renuka A, Yusuf F, Chen J, Dai F, Zoidl G, Ludtke TH, Kispert A, Theiss C, Abdelsabour-Khalaf M, Brand-Saberi B, Wnt11 is required for oriented migration of dermogenic progenitor cells from the dorsomedial lip of the avian dermomyotome. PLoS One. 2014;9(3):e92679
1	J:215309 Patterson ES, Waller LE, Kroll KL, Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. Dev Biol. 2014 Sep 1;393(1):44-56
1	J:344102 Racedo SE, Liu Y, Shi L, Zheng D, Morrow BE, Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
1	J:219797 Ranghini EJ, Dressler GR, Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
1*	J:36716 Tajbakhsh S, Rocancourt D, Buckingham M, Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Nature. 1996 Nov 21;384(6606):266-70
1	J:270543 Tanahashi H, Suzuki T, Deletion of Lrp4 increases the incidence of microphthalmia. Biochem Biophys Res Commun. 2018 Nov 30;506(3):478-484
2	J:138547 Tanaka TS, Davey RE, Lan Q, Zandstra PW, Stanford WL, Development of a gene-trap vector with a highly sensitive fluorescent protein reporter system for expression profiling. Genesis. 2008 Jul;46(7):347-56
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
7	J:166907 Tran TH, Jarrell A, Zentner GE, Welsh A, Brownell I, Scacheri PC, Atit R, Role of canonical Wnt signaling/ss-catenin via Dermo1 in cranial dermal cell development. Development. 2010 Dec;137(23):3973-84
1	J:300455 Vu TH, Takechi M, Shimizu M, Kitazawa T, Higashiyama H, Iwase A, Kurihara H, Iseki S, Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme. Sci Rep. 2021 Jan 22;11(1):2092
8	J:171395 Weaving L, Mihelec M, Storen R, Sosic D, Grigg JR, Tam PP, Jamieson RV, Twist2: role in corneal stromal keratocyte proliferation and corneal thickness. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5561-70
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:207612 Zhang L, Li H, Yu J, Cao J, Chen H, Zhao H, Zhao J, Yao Y, Cheng H, Wang L, Zhou R, Yao Z, Guo X, Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
2	J:184918 Zhu X, Zhu H, Zhang L, Huang S, Cao J, Ma G, Feng G, He L, Yang Y, Guo X, Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Dev Biol. 2012 May 15;365(2):328-38