About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Brca1
breast cancer 1
MGI:104537

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E6.5 E7 E7.5 E8.5 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18.5 E19 E20 E A
In situ protein (section) 1 1 1 1 4
In situ RNA (section) 1 1 1 2 2 1 1 4 2 2 1 2 1 1 1 1 1 3
In situ protein (whole mount) 1 1 1 2
In situ RNA (whole mount) 2 3 1
Northern blot 1 1 2 1 2 1 1 3 1 1 1 1 7
Western blot 1 1
RT-PCR 2 2 1 2 1 1 1 1 2 1 4
cDNA clones 1 1 1 1
RNase protection 1 1 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Brca1  breast cancer 1  
Results  Reference
3*J:30135 Abel KJ, Xy J, Yin GY, Lyons RH, Meisler MH, Weber BL, Mouse Brca1: localization sequence analysis and identification of evolutionary conserved domains. Hum Mol Genet. 1995 Dec;4(12):2265-73
1*J:50839 Ayi TC, Tsan JT, Hwang LY, Bowcock AM, Baer R, Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene. 1998 Oct 22;17(16):2143-8
1J:74077 Bennett LM, McAllister KA, Blackshear PE, Malphurs J, Goulding G, Collins NK, Ward T, Bunch DO, Eddy EM, Davis BJ, Wiseman RW, BRCA2-null embryonic survival is prolonged on the BALB/c genetic background. Mol Carcinog. 2000 Jul;28(3):174-83
5J:74101 Bernard-Gallon DJ, De Latour MP, Sylvain V, Vissac C, Aunoble B, Chassagne J, Bignon YJ, Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int J Oncol. 2001 Feb;18(2):271-80
5J:45456 Blackshear PE, Goldsworthy SM, Foley JF, McAllister KA, Bennett LM, Collins NK, Bunch DO, Brown P, Wiseman RW, Davis BJ, Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene. 1998 Jan 8;16(1):61-8
1*J:67880 Chandler J, Hohenstein P, Swing D, Tessarollo L, Sharan S, Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice. Genesis. 2001 Feb;29(2):72-7
5J:38616 Connor F, Smith A, Wooster R, Stratton M, Dixon A, Campbell E , Tait TM , Freeman T , Ashworth A, Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene. Hum Mol Genet. 1997 Feb;6(2):291-300
1J:173089 Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Toth A, Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat Cell Biol. 2011 May;13(5):599-610
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2*J:31571 Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH, Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996 Feb;12(2):191-4
2*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
5J:33880 Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW, The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28;85(7):1009-23
1J:69602 Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R, A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50
1J:193691 Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, Hu SS, Cattaneo A, Doherty P, Mackie K, Harkany T, Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1935-40
1J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
3J:153169 Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, Hoog C, BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes. J Cell Sci. 2009 Jul 15;122(Pt 14):2446-52
1J:161203 Kumar R, Bourbon HM, de Massy B, Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 2010 Jun 15;24(12):1266-80
1J:147414 Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C, Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet. 2008 Oct;4(10):e1000241
15J:29684 Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P, Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 1995 Nov 1;9(21):2712-22
13J:28391 Marquis ST, Rajan JV, Wynshaw-Boris A, Xu J, Yin GY, Abel KJ, Weber BL, Chodosh LA, The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995 Sep;11(1):17-26
1*J:84329 McCarthy EE, Celebi JT, Baer R, Ludwig T, Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol. 2003 Jul;23(14):5056-63
5J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1J:149563 Pulvers JN, Huttner WB, Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors. Development. 2009 Jun;136(11):1859-68
8J:40064 Rajan JV, Marquis ST, Gardner HP, Chodosh LA, Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol. 1997 Apr 15;184(2):385-401
1*J:161528 Rantakari P, Nikkila J, Jokela H, Ola R, Pylkas K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R, Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9
2J:30136 Sharan SK, Wims M, Bradley A, Murine Brca1: sequence and significance for human missense mutations. Hum Mol Genet. 1995 Dec;4(12):2275-8
1J:192592 Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C, BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
1J:40595 Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW, Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997 May 15;11(10):1242-52
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1J:91673 Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX, Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem. 2004 Jul 9;279(28):29606-14
1J:85108 Wong JC, Alon N, Mckerlie C, Huang JR, Meyn MS, Buchwald M, Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003 Aug 15;12(16):2063-76
1*J:70271 Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX, Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71
4*J:54105 Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX, Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999 Mar;3(3):389-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory