Symbol Name ID |
Yap1
yes-associated protein 1 MGI:103262 |
Age | E0.5 | E1 | E1.5 | E2 | E2.5 | E3 | E3.5 | E4 | E5.5 | E6.5 | E7.5 | E8.5 | E9.5 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E | P |
Immunohistochemistry (section) | 2 | 1 | 4 | 1 | 1 | 1 | 8 | 22 | 3 | 22 | 2 | 28 | 1 | 31 | 2 | 34 | 2 | 26 | 3 | 22 | 1 | 11 | 2 | 29 | 43 | |||||||
In situ RNA (section) | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 1 | 1 | |||||||||||||||||||||
Immunohistochemistry (whole mount) | 1 | 2 | 1 | 4 | 6 | 9 | 11 | 1 | 1 | 1 | 1 | 2 | ||||||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | ||||||||||||||||||||||||
In situ reporter (knock in) | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||||||||||
Western blot | 1 | 1 | 1 | 1 | 1 | 1 | 6 | 4 | 9 | 7 | 5 | 3 | 6 | 3 | 31 | |||||||||||||||||
RT-PCR | 3 | 2 | 1 | 2 | 1 | 2 | 3 | 2 | 3 | 1 | 4 | 3 | 7 | 6 | 1 | 1 | 2 | 3 | 1 | 15 | ||||||||||||
cDNA clones | 1 | 1 |
Yap1 yes-associated protein 1 (Synonyms: Yap, Yki, yorkie) | |
Results | Reference |
7* | J:236337 Abbassi L, Malki S, Cockburn K, Macaulay A, Robert C, Rossant J, Clarke HJ, Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis. Biol Reprod. 2016 May;94(5):102 |
4 | J:331266 Abou Nader N, Menard A, Levasseur A, St-Jean G, Boerboom D, Zamberlam G, Boyer A, Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate. Int J Mol Sci. 2022 Nov 5;23(21) |
1* | J:307271 Airik M, Schuler M, McCourt B, Weiss AC, Herdman N, Ludtke TH, Widmeier E, Stolz DB, Nejak-Bowen KN, Yimlamai D, Wu YL, Kispert A, Airik R, Hildebrandt F, Loss of Anks6 leads to YAP deficiency and liver abnormalities. Hum Mol Genet. 2020 Nov 4;29(18):3064-3080 |
1 | J:264380 Artap S, Manderfield LJ, Smith CL, Poleshko A, Aghajanian H, See K, Li L, Jain R, Epstein JA, Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018 Aug 1;440(1):22-30 |
1 | J:239796 Badouel C, Zander MA, Liscio N, Bagherie-Lachidan M, Sopko R, Coyaud E, Raught B, Miller FD, McNeill H, Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Development. 2015 Aug 15;142(16):2781-91 |
5 | J:226938 Bagherie-Lachidan M, Reginensi A, Pan Q, Zaveri HP, Scott DA, Blencowe BJ, Helmbacher F, McNeill H, Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015 Aug 1;142(15):2564-73 |
1 | J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068 |
1 | J:227651 Bessonnard S, Mesnard D, Constam DB, PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. J Cell Biol. 2015 Sep 28;210(7):1185-97 |
3 | J:338901 Boogerd CJ, Perini I, Kyriakopoulou E, Han SJ, La P, van der Swaan B, Berkhout JB, Versteeg D, Monshouwer-Kloots J, van Rooij E, Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023 Aug 5;14(1):4716 |
4 | J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382 |
2 | J:316303 Camacho Leal MDP, Costamagna A, Tassone B, Saoncella S, Simoni M, Natalini D, Dadone A, Sciortino M, Turco E, Defilippi P, Calautti E, Cabodi S, Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation. Cell Commun Signal. 2018 Nov 3;16(1):73 |
2 | J:205294 Cappello S, Gray MJ, Badouel C, Lange S, Einsiedler M, Srour M, Chitayat D, Hamdan FF, Jenkins ZA, Morgan T, Preitner N, Uster T, Thomas J, Shannon P, Morrison V, Di Donato N, Van Maldergem L, Neuhann T, Newbury-Ecob R, Swinkells M, Terhal P, Wilson LC, Zwijnenburg PJ, Sutherland-Smith AJ, Black MA, Markie D, Michaud JL, Simpson MA, Mansour S, McNeill H, Gotz M, Robertson SP, Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Nat Genet. 2013 Nov;45(11):1300-8 |
4 | J:301556 Cha B, Ho YC, Geng X, Mahamud MR, Chen L, Kim Y, Choi D, Kim TH, Randolph GJ, Cao X, Chen H, Srinivasan RS, YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development. 2020 Dec 13;147(23):dev195453 |
1 | J:333323 Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y, PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood. 2023 Jan 19;141(3):244-259 |
2 | J:223357 Chen Q, Zhang L, de Crombrugghe B, Krahe R, Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation. FASEB J. 2015 Jun;29(6):2555-65 |
1 | J:337001 Cheng C, Cong Q, Liu Y, Hu Y, Liang G, Dioneda KMM, Yang Y, Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression. Sci Adv. 2023 Jun 16;9(24):eadf6927 |
1* | J:308788 Cheong SS, Akram KM, Matellan C, Kim SY, Gaboriau DCA, Hind M, Del Rio Hernandez AE, Griffiths M, Dean CH, The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling. Front Cell Dev Biol. 2020;8:577201 |
4 | J:289355 Cho H, Kim J, Ahn JH, Hong YK, Makinen T, Lim DS, Koh GY, YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis. Circ Res. 2019 Jan 18;124(2):225-242 |
1 | J:283927 Choi SY, Bae H, Jeong SH, Park I, Cho H, Hong SP, Lee DH, Lee CK, Park JS, Suh SH, Choi J, Yang MJ, Jang JY, Onder L, Moon JH, Jeong HS, Adams RH, Kim JM, Ludewig B, Song JH, Lim DS, Koh GY, YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020 Jan 24;11(1):519 |
2 | J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7 |
1 | J:199463 Cockburn K, Biechele S, Garner J, Rossant J, The hippo pathway member nf2 is required for inner cell mass specification. Curr Biol. 2013 Jul 8;23(13):1195-201 |
5 | J:245870 Cotton JL, Li Q, Ma L, Park JS, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL, Mao J, YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme. Dev Cell. 2017 Oct 09;43(1):35-47.e4 |
1 | J:293199 Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD, Francis-West P, Dchs1-Fat4 regulation of osteogenic differentiation in mouse. Development. 2019 Jul 29;146(14):dev176776 |
6 | J:201586 Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ, Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol. 2013 Sep;15(9):1035-44 |
3 | J:234361 Deng Y, Wu A, Li P, Li G, Qin L, Song H, Mak KK, Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair. Cell Rep. 2016 Mar 8;14(9):2224-37 |
2* | J:157660 Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010 Mar 15;19(6):1048-57 |
2 | J:330505 Drake KA, Chaney C, Patel M, Das A, Bittencourt J, Cohn M, Carroll TJ, Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney. J Am Soc Nephrol. 2022 Aug 2; |
2 | J:235531 Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ, Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development. 2016 May 15;143(10):1674-87 |
1 | J:234059 Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R, Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J Cell Sci. 2015 Dec 1;128(23):4293-305 |
1 | J:44866 Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M, The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997 Dec 26;272(52):32869-77 |
2 | J:267596 Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli FM, Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018 Nov 30;9(1):5082 |
1 | J:275506 Frum T, Ralston A, Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development. Methods Mol Biol. 2019;1893:335-352 |
6 | J:255620 Gao T, Zhou D, Yang C, Singh T, Penzo-Mendez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ, Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1 |
1 | J:308973 Gao Y, Sun Y, Ercan-Sencicek AG, King JS, Akerberg BN, Ma Q, Kontaridis MI, Pu WT, Lin Z, YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021 Jun 22;22(13) |
3 | J:307319 George NM, Boerner BP, Mir SU, Guinn Z, Sarvetnick NE, Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass. Mol Endocrinol. 2015 Nov;29(11):1594-607 |
4 | J:192856 George NM, Day CE, Boerner BP, Johnson RL, Sarvetnick NE, Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol. 2012 Dec;32(24):5116-28 |
2 | J:259888 Gnedeva K, Jacobo A, Salvi JD, Petelski AA, Hudspeth AJ, Elastic force restricts growth of the murine utricle. Elife. 2017 Jul 25;6:e25681 |
6 | J:290788 Gnedeva K, Wang X, McGovern MM, Barton M, Tao L, Trecek T, Monroe TO, Llamas J, Makmura W, Martin JF, Groves AK, Warchol M, Segil N, Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13552-13561 |
3 | J:307272 Godin P, Tsoi M, Paquet M, Boerboom D, YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct. Reproduction. 2020 Aug;160(2):307-318 |
3 | J:333075 Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD, YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. J Dent Res. 2020 Nov;99(12):1387-1396 |
1 | J:321672 Goodwin K, Jaslove JM, Tao H, Zhu M, Hopyan S, Nelson CM, Patterning the embryonic pulmonary mesenchyme. iScience. 2022 Mar 18;25(3):103838 |
1 | J:290729 Grundl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP, Gaubatz S, Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. PLoS Genet. 2020 May;16(5):e1008818 |
1 | J:243207 Haque F, Kaku Y, Fujimura S, Ohmori T, Adelstein RS, Nishinakamura R, Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia. Dev Biol. 2017 Jul 01;427(1):121-130 |
2 | J:170963 Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22;332(6028):458-61 |
1 | J:257620 Hertig V, Matos-Nieves A, Garg V, Villeneuve L, Mamarbachi M, Caland L, Calderone A, Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis. J Cell Physiol. 2018 Apr;233(4):3218-3229 |
3 | J:239830 Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans SM, Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017 Feb 01;127(2):569-582 |
3* | J:170558 Hoeing K, Zscheppang K, Mujahid S, Murray S, Volpe MV, Dammann CE, Nielsen HC, Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation. Biochim Biophys Acta. 2011 Mar;1813(3):480-91 |
2* | J:119488 Hossain Z, Ali SM, Ko HL, Xu J, Ng CP, Guo K, Qi Z, Ponniah S, Hong W, Hunziker W, Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1631-6 |
2 | J:302131 Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY, LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis. Nat Commun. 2021 Jan 28;12(1):662 |
8* | J:283394 Hughes LJ, Park R, Lee MJ, Terry BK, Lee DJ, Kim H, Cho SH, Kim S, Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation. Dev Biol. 2020 Jan 1;457(1):150-162 |
7 | J:289493 Isago H, Mitani A, Mikami Y, Horie M, Urushiyama H, Hamamoto R, Terasaki Y, Nagase T, Epithelial Expression of YAP and TAZ Is Sequentially Required in Lung Development. Am J Respir Cell Mol Biol. 2020 Feb;62(2):256-266 |
2 | J:304850 Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernandez-Baldovinos J, Zhou L, Hoss C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Grone HJ, Graumann PL, Niessen CM, Offermanns S, Wickstrom SA, Worzfeld T, Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun. 2021 Feb 26;12(1):1308 |
1 | J:199283 Kaneko KJ, Depamphilis ML, TEAD4 establishes the energy homeostasis essential for blastocoel formation. Development. 2013 Sep;140(17):3680-90 |
2 | J:322702 Kaplan MM, Flucher BE, Counteractive and cooperative actions of muscle beta-catenin and CaV1.1 during early neuromuscular synapse formation. iScience. 2022 Apr 15;25(4):104025 |
2 | J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748 |
1 | J:239820 Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM, Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017 Feb 01;127(2):593-607 |
1 | J:321498 Kim EJY, Sorokin L, Hiiragi T, ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development. 2022 Jan 1;149(1):dev200140 |
1 | J:242892 Kim J, Kim YH, Kim J, Park DY, Bae H, Lee DH, Kim KH, Hong SP, Jang SP, Kubota Y, Kwon YG, Lim DS, Koh GY, YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017 Sep 1;127(9):3441-3461 |
7* | J:237224 Kim JY, Park R, Lee JH, Shin J, Nickas J, Kim S, Cho SH, Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol. 2016 Nov 15;419(2):336-347 |
1 | J:271625 Kim KH, Nakaoka Y, Augustin HG, Koh GY, Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly. Cell Rep. 2018 May 22;23(8):2455-2466 |
2 | J:288374 Kostic M, Paridaen JTML, Long KR, Kalebic N, Langen B, Grubling N, Wimberger P, Kawasaki H, Namba T, Huttner WB, YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex. Cell Rep. 2019 Apr 23;27(4):1103-1118.e6 |
4 | J:238700 Kwan J, Sczaniecka A, Arash EH, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V, DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016 Dec 15;30(24):2696-2709 |
3* | J:309394 Kwon HJ, Li L, Jung HS, Hippo pathway/Yap regulates primary enamel knot and dental cusp patterning in tooth morphogenesis. Cell Tissue Res. 2015 Nov;362(2):447-51 |
2 | J:276459 Lahrouchi N, George A, Ratbi I, Schneider R, Elalaoui SC, Moosa S, Bharti S, Sharma R, Abu-Asab M, Onojafe F, Adadi N, Lodder EM, Laarabi FZ, Lamsyah Y, Elorch H, Chebbar I, Postma AV, Lougaris V, Plebani A, Altmueller J, Kyrieleis H, Meiner V, McNeill H, Bharti K, Lyonnet S, Wollnik B, Henrion-Caude A, Berraho A, Hildebrandt F, Bezzina CR, Brooks BP, Sefiani A, Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Nat Commun. 2019 Mar 12;10(1):1180 |
2 | J:318015 Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA, Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol. 2015 Feb;7(1):35-47 |
4 | J:317151 Lavado A, Gangwar R, Pare J, Wan S, Fan Y, Cao X, YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development. Dev Biol. 2021 Dec;480:39-49 |
3* | J:199301 Lavado A, He Y, Pare J, Neale G, Olson EN, Giovannini M, Cao X, Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34 |
2 | J:272393 Lavado A, Park JY, Pare J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X, The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018 Dec 3;47(5):576-591.e8 |
2 | J:217604 Lavado A, Ware M, Pare J, Cao X, The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development. 2014 Nov;141(21):4182-93 |
5 | J:240786 Lee DH, Park JO, Kim TS, Kim SK, Kim TH, Kim MC, Park GS, Kim JH, Kuninaka S, Olson EN, Saya H, Kim SY, Lee H, Lim DS, LATS-YAP/TAZ controls lineage specification by regulating TGFbeta signaling and Hnf4alpha expression during liver development. Nat Commun. 2016 Jun 30;7:11961 |
1 | J:134270 Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, Lim DS, A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008 Apr 23;27(8):1231-42 |
3 | J:240835 Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD, alphaE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 Jul 13;7:12133 |
6* | J:170274 Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS, Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):163-70 |
4 | J:190509 Li Y, Hibbs MA, Gard AL, Shylo NA, Yun K, Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells. 2012 Apr;30(4):741-52 |
1 | J:296989 Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N, Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020 Sep;585(7825):404-409 |
3* | J:224948 Lin C, Yao E, Chuang PT, A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13 |
5 | J:244106 Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT, YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 Mar 21;6:e21130 |
1 | J:320195 Liu B, Sun LH, Huang YF, Guo LJ, Luo LS, Protein phosphatase 2ACalpha gene knock-out results in cortical atrophy through activating hippo cascade in neuronal progenitor cells. Int J Biochem Cell Biol. 2018 Feb;95:53-62 |
3 | J:224422 Liu M, Zhao S, Lin Q, Wang XP, YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues. Mol Cell Biol. 2015 Apr;35(8):1449-61 |
3 | J:267913 Liu WA, Chen S, Li Z, Lee CH, Mirzaa G, Dobyns WB, Ross ME, Zhang J, Shi SH, PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia. Genes Dev. 2018 Jun 1;32(11-12):763-780 |
3 | J:274694 Lodge EJ, Santambrogio A, Russell JP, Xekouki P, Jacques TS, Johnson RL, Thavaraj S, Bornstein SR, Andoniadou CL, Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade. Elife. 2019 Mar 26;8:e43996 |
6 | J:213950 Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV, The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014 Jul 28;30(2):137-50 |
11 | J:267771 Mamidi A, Prawiro C, Seymour PA, de Lichtenberg KH, Jackson A, Serup P, Semb H, Mechanosignalling via integrins directs fate decisions of pancreatic progenitors. Nature. 2018 Dec;564(7734):114-118 |
1 | J:239791 Manderfield LJ, Aghajanian H, Engleka KA, Lim LY, Liu F, Jain R, Li L, Olson EN, Epstein JA, Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development. 2015 Sep 01;142(17):2962-71 |
3 | J:315934 Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA, Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Rep. 2014 Dec 11;9(5):1885-1895 |
3 | J:239657 Mao Y, Francis-West P, Irvine KD, Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015 Aug 01;142(15):2574-85 |
1 | J:169135 Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD, Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57 |
1* | J:335242 Marshall AR, Galea GL, Copp AJ, Greene NDE, The surface ectoderm exhibits spatially heterogenous tension that correlates with YAP localisation during spinal neural tube closure in mouse embryos. Cells Dev. 2023 Apr 15;174:203840 |
1* | J:329537 Martinez Traverso IM, Steimle JD, Zhao X, Wang J, Martin JF, LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. Development. 2022 Sep 15;149(18):dev200860 |
1 | J:208147 Matsumoto S, Fujii S, Sato A, Ibuka S, Kagawa Y, Ishii M, Kikuchi A, A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J. 2014 Apr 1;33(7):702-18 |
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4* | J:317196 Zhang Y, Tan YY, Chen PP, Xu H, Xie SJ, Xu SJ, Li B, Li JH, Liu S, Yang JH, Zhou H, Qu LH, Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development. Cell Death Dis. 2021 Dec 14;12(12):1161 |
1 | J:288809 Zhang Z, Mu Y, Zhang J, Zhou Y, Cattaneo P, Veevers J, Peter AK, Manso AM, Knowlton KU, Zhou X, Evans SM, Ross RS, Chen J, Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 Mar 19;139(12):1554-1556 |
5 | J:316565 Zhang ZW, Men T, Feng RC, Li YC, Zhou D, Teng CB, miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1. Cell Physiol Biochem. 2013;32(6):1808-17 |
1 | J:201137 Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T, Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-E3829 |
3 | J:292430 Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y, Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Elife. 2020 Mar 18;9:e52779 |
2 | J:261328 Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H, Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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