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Gene Expression Literature Summary

65 matching records from 65 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E4 E5 E6 E7 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 1 1 1 10 1 6 4 4 3 7 2 8 3 10 2 5 1 4 1 4 1 9
In situ RNA (section) 1 1 2 1 1 2 1 2 2 1 3 2 1 1 3 3
In situ protein (whole mount) 1 1
In situ RNA (whole mount) 1 2 3 2 6 1 1
In situ reporter (knock in) 1 1 1 1 1 1 1
Northern blot 1 1 1 2
Western blot 2 1 1 3 1 1 2 2 2 1
RT-PCR 3 7 1 6 1 3 1 4 2 4 3 2 2 4
cDNA clones 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Vcan  versican   (Synonyms: 5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M)
Results  Reference
2J:166547 Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A, Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum Mol Genet. 2010 Dec 15;19(24):4918-29
1*J:174611 Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott DA, Stevens MV, Camenisch TD, Conway SJ, Doetschman T, Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn. 2011 Jul 20;
1J:42573 Berk M, Desai SY, Heyman HC, Colmenares C, Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes Dev. 1997 Aug 15;11(16):2029-39
4*J:172645 Boerboom D, Lafond JF, Zheng X, Lapointe E, Mittaz L, Boyer A, Pritchard MA, Demayo FJ, Mort JS, Drolet R, Richards JS, Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011 Jul;240(7):1806-14
4J:213297 Briggs LE, Phelps AL, Brown E, Kakarla J, Anderson RH, van den Hoff MJ, Wessels A, Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation. Circ Res. 2013 May 24;112(11):1420-32
1J:213432 Burns TA, Dours-Zimmermann MT, Zimmermann DR, Krug EL, Comte-Walters S, Reyes L, Davis MA, Schey KL, Schwacke JH, Kern CB, Mjaatvedt CH, Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles. PLoS One. 2014;9(2):e89133
1J:198628 Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL, Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
1J:63748 Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A Jr, Kubalak S, Klewer SE, McDonald JA, Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme [see comments]. J Clin Invest. 2000 Aug;106(3):349-60
3J:161984 Capehart AA, Proteolytic cleavage of versican during limb joint development. Anat Rec (Hoboken). 2010 Feb;293(2):208-14
2*J:112220 Caruana G, Cullen-McEwen L, Nelson AL, Kostoulias X, Woods K, Gardiner B, Davis MJ, Taylor DF, Teasdale RD, Grimmond SM, Little MH, Bertram JF, Spatial gene expression in the T-stage mouse metanephros. Gene Expr Patterns. 2006 Dec;6(8):807-25
1J:55748 Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, Chao MV, Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 1999 Sep;126(18):4027-37
1J:165936 Choocheep K, Hatano S, Takagi H, Watanabe H, Kimata K, Kongtawelert P, Watanabe H, Versican facilitates chondrocyte differentiation and regulates joint morphogenesis. J Biol Chem. 2010 Jul 2;285(27):21114-25
1*J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
16J:179734 Cooley MA, Fresco VM, Dorlon ME, Twal WO, Lee NV, Barth JL, Kern CB, Iruela-Arispe ML, Argraves WS, Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev Dyn. 2012 Feb;241(2):303-14
1J:185743 Cotney J, Leng J, Oh S, DeMare LE, Reilly SK, Gerstein MB, Noonan JP, Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
1J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
5J:175544 Dupuis LE, McCulloch DR, McGarity JD, Bahan A, Wessels A, Weber D, Diminich AM, Nelson CM, Apte SS, Kern CB, Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease. Dev Biol. 2011 Sep 1;357(1):152-64
1J:112685 Dutt S, Kleber M, Matasci M, Sommer L, Zimmermann DR, Versican V0 and V1 guide migratory neural crest cells. J Biol Chem. 2006 Apr 28;281(17):12123-31
2J:166902 Enomoto H, Nelson CM, Somerville RP, Mielke K, Dixon LJ, Powell K, Apte SS, Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development. 2010 Dec;137(23):4029-38
1J:139508 Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP, Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 1;22(15):2111-24
1J:171615 Georgas KM, Chiu HS, Lesieur E, Rumballe BA, Little MH, Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
3*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:185218 Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM, CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One. 2012;7(2):e30562
13J:49941 Henderson DJ, Copp AJ, Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart. Circ Res. 1998 Sep 7;83(5):523-32
6J:45678 Henderson DJ, Ybot-Gonzalez P, Copp AJ, Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch). Mech Dev. 1997 Dec;69(1-2):39-51
1J:83512 Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A, Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Anat Embryol (Berl). 2003 Apr;206(5):373-80
2J:189213 Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, Radtke F, Simons M, Wang Y, Iruela-Arispe ML, Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development. 2012 Dec;139(23):4449-60
3J:22294 Ito K, Shinomura T, Zako M, Ujita M, Kimata K, Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing. J Biol Chem. 1995 Jan 13;270(2):958-65
4J:121090 Ito Y, Hamazaki TS, Ohnuma K, Tamaki K, Asashima M, Okochi H, Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133. J Invest Dermatol. 2007 May;127(5):1052-60
4J:179089 Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT, Stolz DB, Davis EC, Dichek DA, Transforming Growth Factor-beta Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):e1-e11
3*J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
6J:81588 Kaplan F, Comber J, Sladek R, Hudson TJ, Muglia LJ, Macrae T, Gagnon S, Asada M, Brewer JA, Sweezey NB, The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development. Am J Respir Cell Mol Biol. 2003 Jan;28(1):33-41
4J:118346 Kern CB, Norris RA, Thompson RP, Argraves WS, Fairey SE, Reyes L, Hoffman S, Markwald RR, Mjaatvedt CH, Versican proteolysis mediates myocardial regression during outflow tract development. Dev Dyn. 2007 Mar;236(3):671-83
13*J:119223 Kern CB, Twal WO, Mjaatvedt CH, Fairey SE, Toole BP, Iruela-Arispe ML, Argraves WS, Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn. 2006 Aug;235(8):2238-47
2J:159721 Kern CB, Wessels A, McGarity J, Dixon LJ, Alston E, Argraves WS, Geeting D, Nelson CM, Menick DR, Apte SS, Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol. 2010 May;29(4):304-16
1J:56084 Kishimoto J, Ehama R, Wu L, Jiang S, Jiang N, Burgeson RE, Selective activation of the versican promoter by epithelial- mesenchymal interactions during hair follicle development. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7336-41
1J:209780 Krcmery J, Gupta R, Sadleir RW, Ahrens MJ, Misener S, Kamide C, Fitchev P, Losordo DW, Crawford SE, Simon HG, Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. PLoS One. 2013;8(11):e80809
1J:207643 Kruithof BP, Kruithof-De-Julio M, Poelmann RE, Gittenberger-De-Groot AC, Gaussin V, Goumans MJ, Remodeling of the myocardium in early trabeculation and cardiac valve formation; a role for TGFbeta2. Int J Dev Biol. 2013;57(11-12):853-63
1J:183686 Lin CY, Lin CJ, Chen CH, Chen RM, Zhou B, Chang CP, The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development. J Mol Cell Cardiol. 2012 May;52(5):1096-102
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2J:148803 McCulloch DR, Goff CL, Bhatt S, Dixon LJ, Sandy JD, Apte SS, Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns. 2009 Feb 27;
8J:155754 McCulloch DR, Nelson CM, Dixon LJ, Silver DL, Wylie JD, Lindner V, Sasaki T, Cooley MA, Argraves WS, Apte SS, ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell. 2009 Nov;17(5):687-98
1J:136358 Mecha M, Rabadan MA, Pena-Melian A, Valencia M, Mondejar T, Blanco MJ, Expression of TGF-betas in the embryonic nervous system: analysis of interbalance between isoforms. Dev Dyn. 2008 Jun;237(6):1709-17
4J:49019 Miosge N, Sasaki T, Chu ML, Herken R, Timpl R, Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations. Cell Mol Life Sci. 1998 Jun;54(6):606-13
3*J:50233 Mjaatvedt CH, Yamamura H, Capehart AA, Turner D, Markwald RR, The Cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation. Dev Biol. 1998 Oct 1;202(1):56-66
4*J:29295 Naso MF, Morgan JL, Buchberg AM, Siracusa LD, Iozzo RV, Expression pattern and mapping of the murine versican gene (Cspg2) to chromosome 13. Genomics. 1995 Sep 1;29(1):297-300
1J:50400 Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T, Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 1998 Sep;125(18):3719-29
6J:171486 Rutter M, Wang J, Huang Z, Kuliszewski M, Post M, Gli2 influences proliferation in the developing lung through regulation of cyclin expression. Am J Respir Cell Mol Biol. 2010 May;42(5):615-25
4J:84728 San Martin S, Soto-Suazo M, Zorn TM, Distribution of versican and hyaluronan in the mouse uterus during decidualization. Braz J Med Biol Res. 2003 Aug;36(8):1067-71
3J:163649 Sani FV, Kaartinen V, El Shahawy M, Linde A, Gritli-Linde A, Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse. Eur J Oral Sci. 2010 Jun;118(3):221-36
1J:202654 Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA, Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 1;96(1):109-19
3J:160194 Shaw L, Johnson PA, Kimber SJ, Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):155-65
4J:86321 Shibata S, Fukada K, Imai H, Abe T, Yamashita Y, In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage. J Anat. 2003 Oct;203(4):425-32
3J:133403 Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ, The secreted metalloprotease AMAMTS20 is required for melanoblast survival. PLoS Genet. 2008;4(2):e1000003
1J:147647 Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, Conway SJ, Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 2008 Apr 11;102(7):752-60
13J:97502 Snow HE, Riccio LM, Mjaatvedt CH, Hoffman S, Capehart AA, Versican expression during skeletal/joint morphogenesis and patterning of muscle and nerve in the embryonic mouse limb. Anat Rec A Discov Mol Cell Evol Biol. 2005 Feb;282(2):95-105
4J:80734 Soto-Suazo M, San Martin S, Ferro ES, Zorn TM, Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse. Histochem Cell Biol. 2002 Jul;118(1):69-78
6J:132583 Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP, Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008 Feb;14(2):298-311
2J:187204 Thomas PS, Sridurongrit S, Ruiz-Lozano P, Kaartinen V, Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One. 2012;7(4):e35539
2J:107480 Togi K, Yoshida Y, Matsumae H, Nakashima Y, Kita T, Tanaka M, Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development. Biochem Biophys Res Commun. 2006 Apr 28;343(1):144-51
2J:175540 Tsau C, Ito M, Gromova A, Hoffman MP, Meech R, Makarenkova HP, Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling. Development. 2011 Aug;138(15):3307-17
1J:185565 Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB, Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol. 2012 Jun 15;366(2):111-24
2J:195050 Wilson CL, Gough PJ, Chang CA, Chan CK, Frey JM, Liu Y, Braun KR, Chin MT, Wight TN, Raines EW, Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
6J:128009 Wirrig EE, Snarr BS, Chintalapudi MR, O'neal JL, Phelps AL, Barth JL, Fresco VM, Kern CB, Mjaatvedt CH, Toole BP, Hoffman S, Trusk TC, Argraves WS, Wessels A, Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol. 2007 Oct 15;310(2):291-303
1J:105811 Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C, Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85

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