Gene Expression Literature Summary

• Symbol: E2f1
• Name: E2F transcription factor 1
• ID: MGI:101941

65 matching records from 65 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E8.5	E9.5	E10	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)													1		1		2		1		1	1		1				1	1
In situ RNA (section)									1	1	1	1	4		6	1	6		7	1	7	5		3		4	2	1	6
In situ RNA (whole mount)										1		4	1	1			1				2
Western blot										1		1	1	1	1	1	6	1	2	1	4	3	2	1		1		1	6
RT-PCR	1	1	2	3	2	2	3	1		1	1	1			3		6		4	1	2		1	2	1	3		1	17
RNase protection																			1		1	1		1		1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

E2f1  E2F transcription factor 1   (Synonyms: E2F-1)
Results	Reference
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
6*	J:88220 Amasaki H, Ogawa M, Nagasao J, Mutoh K, Ichihara N, Asari M, Shiota K, Distributional changes of BrdU, PCNA, E2F1 and PAL31 molecules in developing murine palatal rugae. Ann Anat. 2003 Dec;185(6):517-23
3*	J:108720 Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P, Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell. 2006 May;10(5):563-73
3	J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
1	J:171415 Castro DS, Martynoga B, Parras C, Ramesh V, Pacary E, Johnston C, Drechsel D, Lebel-Potter M, Garcia LG, Hunt C, Dolle D, Bithell A, Ettwiller L, Buckley N, Guillemot F, A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev. 2011 May 1;25(9):930-45
2*	J:48572 Charng MJ, Frenkel PA, Lin Q, Yamada M, Schwartz RJ, Olson EN , Overbeek P , Schneider MD, A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice. Dev Biol. 1998 Jul 1;199(1):72-9
2	J:190713 Chen HZ, Ouseph MM, Li J, Pecot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G, Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202
1	J:74730 Chen Q, Ash JD, Branton P, Fromm L, Overbeek PA, Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002 Feb 7;21(7):1028-37
1	J:90298 Chen Q, Liang D, Fromm LD, Overbeek PA, Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb. J Biol Chem. 2004 Apr 23;279(17):17667-73
1	J:149879 Chen Q, Liang D, Overbeek PA, Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice. Mol Vis. 2008;14:602-14
3	J:236189 Chinnam M, Wang X, Zhang X, Goodrich DW, Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice. Mol Cell Biol. 2016 Jun 1;36(11):1621-7
8	J:40858 Dagnino L, Fry CJ, Bartley SM, Farnham P, Gallie BL, Phillips RA, Expression patterns of the E2F family of transcription factors during murine epithelial development. Cell Growth Differ. 1997 May;8(5):553-63
14*	J:42771 Dagnino L, Fry CJ, Bartley SM, Farnham P, Gallie BL, Phillips RA, Expression patterns of the E2F family of transcription factors during mouse nervous system development. Mech Dev. 1997 Aug;66(1-2):13-25
1	J:57767 Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, Elson D, Arbeit J, Kipreos ET, Johnson RS, Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet. 1999 Oct;23(2):245-8
5	J:129010 Dirlam A, Spike BT, Macleod KF, Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007 Dec;27(24):8713-28
7*	J:176371 Egashira A, Kano K, Naito K, Preimplantation-embryo-specific Cell-cycle Regulation is Attributable to a Low Expression of Retinoblastoma Protein Rather Than Its Phosphorylation. J Reprod Dev. 2011 Sep 6;57(4):492-9
3	J:89720 Fajas L, Annicotte JS, Miard S, Sarruf D, Watanabe M, Auwerx J, Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest. 2004 May;113(9):1288-95
2*	J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
1	J:317995 Futatsugi A, Utreras E, Rudrabhatla P, Jaffe H, Pant HC, Kulkarni AB, Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle. 2012 Apr 15;11(8):1603-10
1	J:227271 Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS, Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13627-32
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2	J:88217 Hedlund E, Karsten SL, Kudo L, Geschwind DH, Carpenter EM, Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. J Neurosci Res. 2004 Feb 1;75(3):307-19
2*	J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
1	J:193195 Katoh K, Yamazaki R, Onishi A, Sanuki R, Furukawa T, G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70
4	J:171431 Kim SY, Rane SG, The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors. Development. 2011 May;138(10):1903-12
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
9*	J:63376 Kusek JC, Greene RM, Nugent P, Pisano MM, Expression of the E2F family of transcription factors during murine development. Int J Dev Biol. 2000 Apr;44(3):267-77
1	J:321499 Lee DR, Rhodes C, Mitra A, Zhang Y, Maric D, Dale RK, Petros TJ, Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. Elife. 2022 Feb 17;11:e71864
4*	J:253703 Li L, Shi B, Chen J, Li C, Wang S, Wang Z, Zhu G, An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells. Sci Rep. 2017 Jul 11;7(1):5148
1*	J:276637 Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M, Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells. J Biol Chem. 2013 Dec 13;288(50):35626-35
2	J:122733 McClellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D, Bremner R, Park DS, Leone G, Slack RS, Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol. 2007 Jul;27(13):4825-43
1*	J:182713 McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD, Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73
1	J:100687 Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui CC, Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell. 2005 Aug;9(2):293-303
1	J:267889 Moon S, Im SK, Kim N, Youn H, Park UH, Kim JY, Kim AR, An SJ, Kim JH, Sun W, Hwang JT, Kim EJ, Um SJ, Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018 Nov 2;9(11):1118
1	J:311151 Nakano T, Aochi H, Hirasaki M, Takenaka Y, Fujita K, Tamura M, Soma H, Kamezawa H, Koizumi T, Shibuya H, Inomata R, Okuda A, Murakoshi T, Shimada A, Inoue I, Effects of Ppargamma1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Dev Biol. 2021 Oct;478:222-235
1	J:161950 O'Brien KB, Alberich-Jorda M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S, CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul;137(13):2147-56
1	J:240000 Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S, The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development. 2016 Jan 01;143(1):133-46
1	J:226897 Parker A, Cross SH, Jackson IJ, Hardisty-Hughes R, Morse S, Nicholson G, Coghill E, Bowl MR, Brown SD, The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells. Dis Model Mech. 2015 Dec 1;8(12):1555-68
1	J:218949 Perucho L, Artero-Castro A, Guerrero S, Ramon y Cajal S, LLeonart ME, Wang ZQ, RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PLoS One. 2014;9(6):e99956
2*	J:93571 Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL, Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct;131(20):5139-52
1	J:149518 Sakagami K, Gan L, Yang XJ, Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J Neurosci. 2009 May 27;29(21):6932-44
3*	J:117790 Singh S, Yin X, Pisano MM, Greene RM, Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development. Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):35-44
1	J:147145 Susaki E, Nakayama K, Yamasaki L, Nakayama KI, Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5192-7
1*	J:153105 Tallack MR, Keys JR, Humbert PO, Perkins AC, EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem. 2009 Jul 31;284(31):20966-74
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1	J:270077 Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ, Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions. Cell Stem Cell. 2014 May 1;14(5):632-43
10*	J:31363 Tevosian SG, Paulson KE, Bronson R, Yee AS, Expression of the E2F-1/DP-1 transcription factor in murine development. Cell Growth Differ. 1996 Jan;7(1):43-52
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:188139 Tsume M, Kimura-Yoshida C, Mochida K, Shibukawa Y, Amazaki S, Wada Y, Hiramatsu R, Shimokawa K, Matsuo I, Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells. Biochem Biophys Res Commun. 2012 Sep 7;425(4):762-8
1	J:222249 Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, Inamura K, Kim SA, Morikawa T, Mima K, Sukawa Y, Yang J, Meredith G, Fuchs CS, Ogino S, Daley GQ, LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015 May 15;29(10):1074-86
1	J:310313 Vinjamur DS, Wade KJ, Mohamad SF, Haar JL, Sawyer ST, Lloyd JA, Kruppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation. Haematologica. 2014 Oct;99(10):1565-73
6*	J:213978 Vuong L, Brobst DE, Saadi A, Ivanovic I, Al-Ubaidi MR, Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012 Jul;53(8):4821-31
2	J:117307 Wenzel PL, Wu L, de Bruin A, Chong JL, Chen WY, Dureska G, Sites E, Pan T, Sharma A, Huang K, Ridgway R, Mosaliganti K, Sharp R, Machiraju R, Saltz J, Yamamoto H, Cross JC, Robinson ML, Leone G, Rb is critical in a mammalian tissue stem cell population. Genes Dev. 2007 Jan 1;21(1):85-97
2*	J:187480 Westendorp B, Major JL, Nader M, Salih M, Leenen FH, Tuana BS, The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012 Jun;26(6):2569-79
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:25759 Williamson CM, Dutton ER, Abbott CM, Beechey CV, Ball ST, Peters J, Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed. Genet Res. 1995 Apr;65(2):83-93
1	J:264125 Xu Z, Liang Q, Song X, Zhang Z, Lindtner S, Li Z, Wen Y, Liu G, Guo T, Qi D, Wang M, Wang C, Li H, You Y, Wang X, Chen B, Feng H, Rubenstein JL, Yang Z, SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. Development. 2018 Jul 23;145(14):dev165456
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
2	J:159853 Zhang J, Li H, Yabut O, Fitzpatrick H, D'Arcangelo G, Herrup K, Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci. 2010 Apr 14;30(15):5219-28
1	J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247
6*	J:233705 Zhao H, Wang H, Bauzon F, Lu Z, Fu H, Cui J, Zhu L, Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis. J Biol Chem. 2016 May 6;291(19):10201-9
5*	J:26610 Zhao J, Nornes HO, Neuman T, Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing spinal cord. Neurosci Lett. 1995 Apr 28;190(1):49-52
1	J:339443 Zocchi L, Mehta A, Wu SC, Wu J, Gu Y, Wang J, Suh S, Spitale RC, Benavente CA, Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. Oncogenesis. 2020 Feb 18;9(2):25