About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Pou3f4
POU domain, class 3, transcription factor 4
MGI:101894

63 matching records from 63 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E6.5 E7.5 E8.5 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E A
In situ protein (section) 1 1 8 1 1 1 3 1 2 2 2 2 4 1 3 1 1 2 1 1 3
In situ RNA (section) 1 1 5 5 2 6 2 4 1 7 10 1 1 1 3 3 6
In situ protein (whole mount) 1 1
In situ RNA (whole mount) 2 4 2 1 1
Northern blot 1 1
Western blot 1 1
RT-PCR 1 1 1 1 2 2 2 2 2 1 1 2 3 1 3
cDNA clones 1 1
RNase protection 1 1 1 1 1 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pou3f4  POU domain, class 3, transcription factor 4   (Synonyms: Brn4, BRN-4, Otf9)
Results  Reference
1J:41860 Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R , Rubenstein JL, Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron. 1997 Jul;19(1):27-37
3J:120055 Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R, MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3853-8
2J:174114 Batista-Brito R, Machold R, Klein C, Fishell G, Gene expression in cortical interneuron precursors is prescient of their mature function. Cereb Cortex. 2008 Oct;18(10):2306-17
1*J:98482 Bouchard M, Grote D, Craven SE, Sun Q, Steinlein P, Busslinger M, Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. Development. 2005 Jun;132(11):2633-43
3J:175160 Braunstein EM, Crenshaw EB 3rd, Morrow BE, Adams JC, Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol. 2008 Mar;9(1):33-43
1J:150080 Braunstein EM, Monks DC, Aggarwal VS, Arnold JS, Morrow BE, Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis. BMC Dev Biol. 2009;9:31
2J:119653 Castro DS, Skowronska-Krawczyk D, Armant O, Donaldson IJ, Parras C, Hunt C, Critchley JA, Nguyen L, Gossler A, Gottgens B, Matter JM, Guillemot F, Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell. 2006 Dec;11(6):831-44
2J:129103 Chao CS, Loomis ZL, Lee JE, Sussel L, Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15;312(2):523-32
1J:198578 Chervenak AP, Hakim IS, Barald KF, Spatiotemporal expression of zic genes during vertebrate inner ear development. Dev Dyn. 2013 Jul;242(7):897-908
2*J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
7J:179898 Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW, Otic Mesenchyme Cells Regulate Spiral Ganglion Axon Fasciculation through a Pou3f4/EphA4 Signaling Pathway. Neuron. 2012 Jan 12;73(1):49-63
1J:160437 Dames P, Puff R, Weise M, Parhofer KG, Goke B, Gotz M, Graw J, Favor J, Lechner A, Relative roles of the different Pax6 domains for pancreatic alpha cell development. BMC Dev Biol. 2010;10:39
3J:70561 Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG, Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell. 1999 May 28;97(5):587-98
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
13J:36227 Dominov JA, Miller JB, POU homeodomain genes and myogenesis. Dev Genet. 1996;19(2):108-18
1J:154416 Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL, Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009 Sep;58(9):2059-69
1J:99610 Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V, Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005 Jun;3(6):e186
1J:174967 Flandin P, Zhao Y, Vogt D, Jeong J, Long J, Potter G, Westphal H, Rubenstein JL, Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron. 2011 Jun 9;70(5):939-50
1J:175526 Gomez-Lopez S, Wiskow O, Favaro R, Nicolis SK, Price DJ, Pollard SM, Smith A, Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. Glia. 2011 Nov;59(11):1588-99
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
3J:92173 Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB 3rd, Madsen OD, Serup P, The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol. 2004 Apr 1;268(1):123-34
1J:69519 Heydemann A, Nguyen L, Crenshaw EB 3rd, Regulatory regions from the Brn4 promoter direct LACZ expression to the developing forebrain and neural tube. Brain Res Dev Brain Res. 2001 May 31;128(1):83-90
1J:142415 Hoffman BG, Zavaglia B, Beach M, Helgason CD, Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol. 2008;8:81
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
2J:76349 Hussain MA, Miller CP, Habener JF, Brn-4 Transcription Factor Expression Targeted to the Early Developing Mouse Pancreas Induces Ectopic Glucagon Gene Expression in Insulin-producing beta Cells. J Biol Chem. 2002 May 3;277(18):16028-32
1J:194010 Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, Rutter GA, Prentki M, Thorens B, Wahli W, PPARbeta/delta affects pancreatic beta cell mass and insulin secretion in mice. J Clin Invest. 2012 Nov 1;122(11):4105-17
2J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
8J:120581 Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P, Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes. 2000 Feb;49(2):163-76
4J:104323 Jones JM, Montcouquiol M, Dabdoub A, Woods C, Kelley MW, Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci. 2006 Jan 11;26(2):550-8
2J:58952 Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P, Rosenfeld MG, Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14378-82
1J:176201 Kordowich S, Collombat P, Mansouri A, Serup P, Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Dev Biol. 2011;11:52
1J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
1J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:178173 Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L, Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
1J:152582 Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA, The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 2009 Jul;119(7):1888-98
1J:59387 Phippard D, Boyd Y, Reed V, Fisher G, Masson WK, Evans EP, Saunders JC, Crenshaw EB 3rd, The sex-linked fidget mutation abolishes Brn4/Pou3f4 gene expression in the embryonic inner ear. Hum Mol Genet. 2000 Jan 1;9(1):79-85
4J:79100 Riccomagno MM, Martinu L, Mulheisen M, Wu DK, Epstein DJ, Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 2002 Sep 15;16(18):2365-78
8J:30430 Schonemann MD, Ryan AK, McEvilly RJ, O'Connell SM, Arias CA, Kalla KA, Li P, Sawchenko PE, Rosenfeld MG, Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 1995 Dec 15;9(24):3122-35
1*J:63215 Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS, Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000 Aug;127(16):3533-42
2J:52381 Shimazaki T, Arsenijevic Y, Ryan AK, Rosenfeld MG, Weiss S, A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation. EMBO J. 1999 Jan 15;18(2):444-56
4J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
9*J:36967 Sornson MW, Wu W, Dasen JS, Flynn SE, Norman DJ, O'Connell SM, Gukovsky I, Carriere C, Ryan AK, Miller AP, Zuo L, Gleiberman AS, Andersen B, Beamer WG, Rosenfeld MG, Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature. 1996 Nov 28;384(6607):327-33
2J:77999 Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, Mori K, Ogawa M, Noda T, Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 2002 Jul 15;16(14):1760-5
1J:48576 Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA , Rubenstein JL , German MS, Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
4J:145841 Tanaka S, Kamachi Y, Tanouchi A, Hamada H, Jing N, Kondoh H, Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol. 2004 Oct;24(20):8834-46
3J:48144 Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG, Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
2J:66789 Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG, Hedgehog signaling is required for pituitary gland development. Development. 2001 Feb;128(3):377-86
5J:134489 Trowe MO, Maier H, Schweizer M, Kispert A, Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes. Development. 2008 May;135(9):1725-34
2J:160473 Trowe MO, Shah S, Petry M, Airik R, Schuster-Gossler K, Kist R, Kispert A, Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse. Dev Biol. 2010 Jun 1;342(1):51-62
3J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
1J:85590 Vincent M, Guz Y, Rozenberg M, Webb G, Furuta M, Steiner D, Teitelman G, Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis. Endocrinology. 2003 Sep;144(9):4061-9
1*J:127119 Visel A, Carson J, Oldekamp J, Warnecke M, Jakubcakova V, Zhou X, Shaw CA, Alvarez-Bolado G, Eichele G, Regulatory pathway analysis by high-throughput in situ hybridization. PLoS Genet. 2007 Oct 19;3(10):1867-83
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4J:65759 Wang W, Lufkin T, The murine otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. Dev Biol. 2000 Nov 15;227(2):432-49
3J:77320 Wilson ME, Kalamaras JA, German MS, Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev. 2002 Jul;115(1-2):171-6
1J:193048 Wu L, Sagong B, Choi JY, Kim UK, Bok J, A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
1J:174673 Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV, Context-specific {alpha}-to-{beta}-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011 Aug 15;25(16):1680-5
3*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1J:79854 Yun K, Fischman S, Johnson J, De Angelis MH, Weinmaster G, Rubenstein JL, Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development. 2002 Nov;129(21):5029-40
1J:66590 Yun K, Potter S, Rubenstein JL, Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001 Jan;128(2):193-205
2J:123923 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA, A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory