Gene Expression Literature Summary

• Symbol: Fmn1
• Name: formin 1
• ID: MGI:101815

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E	P
Immunohistochemistry (section)																	1
In situ RNA (section)						1										1
In situ RNA (whole mount)		1		2		8		2			1	1		1	1	1
In situ reporter (knock in)						1
Northern blot			1		1		1		1								3
Western blot						1											1
RT-PCR						1		2		1			1			2	4
cDNA clones						1	1	1									2
RNase protection	1	2		2		5		1		2	2						5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fmn1  formin 1   (Synonyms: Fmn, formin-1, ld, limb deformity)
Results	Reference
8	J:29274 Chan DC, Wynshaw-Boris A, Leder P, Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. Development. 1995 Oct;121(10):3151-62
1*	J:71186 Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF, Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol. 2001 Aug 15;236(2):421-35
2*	J:226856 Dutta P, Maiti S, Expression of multiple formins in adult tissues and during developmental stages of mouse brain. Gene Expr Patterns. 2015 Sep-Nov;19(1-2):52-9
1*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
2	J:213598 Hu J, Lu J, Lian G, Ferland RJ, Dettenhofer M, Sheen VL, Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet. 2014 Sep 1;23(17):4663-73
12	J:1859 Jackson-Grusby L, Kuo A, Leder P, A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin. Genes Dev. 1992 Jan;6(1):29-37
1	J:84077 Khokha MK, Hsu D, Brunet LJ, Dionne MS, Harland RM, Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet. 2003 Jul;34(3):303-7
6*	J:17401 Maas R, Elfering S, Glaser T, Jepeal L, Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation. Dev Dyn. 1994 Mar;199(3):214-28
3*	J:22162 Maas RL, Zeller R, Woychik RP, Vogt TF, Leder P, Disruption of formin-encoding transcripts in two mutant limb deformity alleles. Nature. 1990 Aug 30;346(6287):853-5
3*	J:123068 Pavel E, Zhao W, Powell KA, Weinstein M, Kirschner LS, Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region. Int J Dev Biol. 2007;51(4):273-81
4*	J:38417 Wang CC, Chan DC, Leder P, The mouse formin (Fmn) gene: genomic structure, novel exons, and genetic mapping. Genomics. 1997 Feb 1;39(3):303-11
7*	J:10698 Woychik RP, Maas RL, Zeller R, Vogt TF, Leder P, 'Formins': proteins deduced from the alternative transcripts of the limb deformity gene. Nature. 1990 Aug 30;346(6287):850-3
5	J:43337 Wynshaw-Boris A, Ryan G, Deng CX, Chan DC, Jackson-Grusby L, Larson D , Dunmore JH , Leder P, The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Mol Med. 1997 Jun;3(6):372-84
4*	J:46539 Zeller R, Jackson-Grusby L, Leder P, The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation. Genes Dev. 1989 Oct;3(10):1481-92
2*	J:149484 Zhou F, Leder P, Zuniga A, Dettenhofer M, Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet. 2009 Jul 1;18(13):2472-82
1	J:58039 Zuniga A, Haramis AP, McMahon AP, Zeller R, Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature. 1999 Oct 7;401(6753):598-602
4	J:91385 Zuniga A, Michos O, Spitz F, Haramis AP, Panman L, Galli A, Vintersten K, Klasen C, Mansfield W, Kuc S, Duboule D, Dono R, Zeller R, Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 2004 Jul 1;18(13):1553-64
1*	J:49322 Zuniga A, Zeller R, Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development. 1999 Jan;126(1):13-21