Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp1b1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atp1b1
  • is located in the following cellular components:
    • basolateral plasma membrane ^[1]
    • plasma membrane ^[1]
• The gene product of Atp1b1 has been shown to bind to the gene products of Pxk. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Atp1b1
  • participates in the following biological processes:
    • blastocyst development ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atp1b1:
  • participates in the following biological processes:
    • metal ion transport
    • potassium ion transport
    • response to hypoxia
    • sodium ion transport
  • performs the following molecular functions:
    • sodium:potassium-exchanging ATPase activity
  • is located in the following cellular components:
    • apical plasma membrane
    • basolateral plasma membrane
    • caveola
    • sodium:potassium-exchanging ATPase complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atp1b1 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • ion transport
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. MacPhee DJ et al. (2000) Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse. Dev Biol, 222:486-98. (PubMed:10837135)
2. MacPhee DJ et al. (1998) Role of the alpha and beta subunits of Na+,K+-ATPase in trophectoderm differentiation and cavitation Trophoblast Res, 11:87-99.
3. Mao H et al. (2005) MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. J Neurosci, 25:7934-43. (PubMed:16135750)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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