Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lmcd1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. The presence of LIM domains implies involvement in protein-protein interactions. Expression of this gene has been detected in most tissues, with highest expression in skeletal muscle. Transcript variants utilizing alternative polyA signals have been observed. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lmcd1
  • performs the following molecular functions:
    • transcription corepressor activity ^[2]
  • is located in the following cellular components:
    • nucleus ^[2]
• The gene product of Lmcd1 has been shown to bind to the gene products of Gata6. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lmcd1
  • participates in the following biological processes:
    • positive regulation of calcineurin-NFAT signaling cascade ^[1]
    • regulation of cardiac muscle hypertrophy ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Lmcd1
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Gata6 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lmcd1:
  • participates in the following biological processes:
    • positive regulation of calcineurin-NFAT signaling cascade
    • regulation of cardiac muscle hypertrophy
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Lmcd1 encodes a protein or proteins that contain the following InterPro domains: PET domain, Zinc finger, LIM-type, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lmcd1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm

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References

1. Bian ZY et al. (2010) LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling. Hypertension, 55:257-63. (PubMed:20026769)
2. Rath N et al. (2005) LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Mol Cell Biol, 25:8864-73. (PubMed:16199866)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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