Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Timm9. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Timm9
  • participates in the following biological processes:
    • protein import into mitochondrial inner membrane ^[2]
  • is located in the following cellular components:
    • mitochondrial intermembrane space protein transporter complex ^[2]
    • mitochondrion ^{[1, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Timm9:
  • participates in the following biological processes:
    • chaperone-mediated protein transport
    • protein import into mitochondrial inner membrane
  • performs the following molecular functions:
    • chaperone binding
    • protein homodimerization activity
    • transporter activity
  • is located in the following cellular components:
    • mitochondrial inner membrane
    • mitochondrial intermembrane space protein transporter complex
    • mitochondrion

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Timm9 indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • membrane

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Muhlenbein N et al. (2004) Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem, 279:13540-6. (PubMed:14726512)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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