Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lhx6. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 6, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lhx6
  • is located in the following cellular components:
    • nucleus ^[3]
• The gene product of Lhx6 has been shown to bind to the gene products of Ldb1. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lhx6
  • participates in the following biological processes:
    • cell maturation ^[3]
    • cerebral cortex GABAergic interneuron migration ^[3]
    • cerebral cortex radially oriented cell migration ^[3]
    • cerebral cortex tangential migration ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Lhx6
  • participates in the following biological processes:
    • cerebral cortex neuron differentiation based on interactions with Nkx2-1 ^[1]
    • forebrain neuron development based on interactions with Lhx8 ^[4]
    • forebrain neuron fate commitment based on interactions with Nkx2-1 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lhx6:
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Lhx6 encodes a protein or proteins that contain the following InterPro domains: Homeobox, conserved site, Homeodomain, Homeodomain-like, Zinc finger, LIM-type, indicating that the gene product:
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lhx6 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

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References

1. Du T et al. (2008) NKX2.1 specifies cortical interneuron fate by activating Lhx6. Development, 135:1559-67. (PubMed:18339674)
2. Kimura N et al. (1999) A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. J Biochem, 126:180-7. (PubMed:10393337)
3. Liodis P et al. (2007) Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci, 27:3078-89. (PubMed:17376969)
4. Mori T et al. (2004) The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci, 19:3129-41. (PubMed:15217369)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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