Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of C1qbp. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of C1qbp
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}
• The gene product of C1qbp has been shown to bind to the gene products of U2af1l4. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of C1qbp:
  • participates in the following biological processes:
    • mature ribosome assembly
    • negative regulation of defense response to virus
    • negative regulation of interferon-gamma production
    • negative regulation of interleukin-12 production
    • negative regulation of MDA-5 signaling pathway
    • negative regulation of mRNA splicing, via spliceosome
    • negative regulation of RIG-I signaling pathway
    • negative regulation of transcription from RNA polymerase II promoter
    • phosphatidylinositol 3-kinase cascade
    • positive regulation of apoptotic process
    • positive regulation of cell adhesion
    • positive regulation of dendritic cell chemotaxis
    • positive regulation of neutrophil chemotaxis
    • positive regulation of protein kinase B signaling cascade
    • positive regulation of substrate adhesion-dependent cell spreading
    • positive regulation of trophoblast cell migration
    • regulation of complement activation
  • performs the following molecular functions:
    • adrenergic receptor binding
    • complement component C1q binding
    • hyaluronic acid binding
    • kininogen binding
    • protein kinase C binding
    • transcription corepressor activity
    • transcription factor binding
  • is located in the following cellular components:
    • cell surface
    • cytoplasm
    • cytosol
    • extracellular space
    • membrane
    • mitochondrion
    • nucleus

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Summary text based on GO annotations supported by structural data

• C1qbp encodes a protein or proteins that contain the following InterPro domains: Mitochondrial glycoprotein, indicating that the gene product:
  • is located in the following cellular components:
    • mitochondrial matrix

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References

1. Heyd F et al. (2008) Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26. J Biol Chem, 283:19636-45. (PubMed:18460468)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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