Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atoh1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atoh1
  • participates in the following biological processes:
    • auditory receptor cell differentiation ^[15]
    • auditory receptor cell fate determination ^[8]
    • positive regulation of auditory receptor cell differentiation ^{[3, 16]}
    • positive regulation of neuron differentiation ^[4]
    • positive regulation of transcription from RNA polymerase II promoter ^[10]
    • regulation of neuron differentiation ^[5]
  • performs the following molecular functions:
    • chromatin DNA binding ^[13]
    • DNA binding ^[5]
    • sequence-specific DNA binding ^[10]
  • is located in the following cellular components:
    • nucleus ^[4]
• The gene product of Atoh1 has been shown to bind to the gene products of Tcf3. ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Atoh1
  • participates in the following biological processes:
    • apoptotic process ^[2]
    • auditory receptor cell differentiation ^{[2, 15]}
    • auditory receptor cell fate specification ^[1]
    • axon guidance ^[11]
    • brain development ^[6]
    • cell differentiation ^[15]
    • cerebral cortex development ^[9]
    • inner ear development ^[12]
    • inner ear morphogenesis ^{[11, 15]}
    • neuron differentiation ^[7]
    • neuron migration ^[14]
    • positive regulation of inner ear receptor cell differentiation ^{[12, 17]}
    • positive regulation of transcription from RNA polymerase II promoter ^{[9, 13]}

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Summary text based on GO annotations supported by structural data

• Atoh1 encodes a protein or proteins that contain the following InterPro domains: Helix-loop-helix domain, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atoh1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • nervous system development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Bermingham NA et al. (1999) Math1: an essential gene for the generation of inner ear hair cells. Science, 284:1837-41. (PubMed:10364557)
2. Chen P et al. (2002) The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development, 129:2495-505. (PubMed:11973280)
3. Doetzlhofer A et al. (2009) Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell, 16:58-69. (PubMed:19154718)
4. Farah MH et al. (2000) Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development, 127:693-702. (PubMed:10648228)
5. Gazit R et al. (2004) Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development, 131:903-13. (PubMed:14757642)
6. Jensen P et al. (2002) Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J Neurosci, 22:8110-6. (PubMed:12223565)
7. Jensen P et al. (2004) Analysis of cerebellar development in math1 null embryos and chimeras. J Neurosci, 24:2202-11. (PubMed:14999071)
8. Jones JM et al. (2006) Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci, 26:550-8. (PubMed:16407553)
9. Krizhanovsky V et al. (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech Dev, 123:67-75. (PubMed:16325379)
10. Krizhanovsky V et al. (2006) Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites. J Mol Neurosci, 28:211-29. (PubMed:16679559)
11. Matei V et al. (2005) Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn, 234:633-50. (PubMed:16145671)
12. Pan N et al. (2010) Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res, null:null. (PubMed:21146598)
13. Saba R et al. (2005) Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1. Development, 132:2147-55. (PubMed:15788459)
14. Wang VY et al. (2005) Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron, 48:31-43. (PubMed:16202707)
15. Woods C et al. (2004) Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci, 7:1310-8. (PubMed:15543141)
16. Zheng JL et al. (2000) Hes1 is a negative regulator of inner ear hair cell differentiation Development, 127:4551-60. (PubMed:11023859)
17. Zine A et al. (2002) Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice. Hear Res, 170:22-31. (PubMed:12208538)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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