Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Jund. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage, including non-AUG codons, results in the production of different isoforms. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Jund
  • participates in the following biological processes:
    • cellular response to calcium ion ^[1]
  • performs the following molecular functions:
    • DNA binding ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Jund
  • participates in the following biological processes:
    • osteoblast development based on interactions with Men1 ^[3]
    • positive regulation of osteoblast differentiation based on interactions with Men1 ^[3]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Jun ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Jund:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • double-stranded DNA binding
    • ligand-dependent nuclear receptor binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • transcription regulatory region DNA binding
  • is located in the following cellular components:
    • nucleus
    • protein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Jund indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent

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References

1. Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell, 136:1122-35. (PubMed:19303854)
2. Gong P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch Biochem Biophys, 405:265. (PubMed:12220541)
3. Naito J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J Biol Chem, 280:4785-91. (PubMed:15563473)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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