Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hyal1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hyal1
  • participates in the following biological processes:
    • response to virus ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hyal1
  • participates in the following biological processes:
    • embryonic skeletal joint morphogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hyal1:
  • participates in the following biological processes:
    • cell death
    • cellular response to fibroblast growth factor stimulus
    • cellular response to interleukin-1
    • cellular response to pH
    • cellular response to platelet-derived growth factor stimulus
    • cellular response to UV-B
    • hyaluronan biosynthetic process
    • hyaluronan catabolic process
    • hyaluronan metabolic process
    • inflammatory response
    • negative regulation of cell growth
    • negative regulation of cell proliferation
    • positive regulation of angiogenesis
    • positive regulation of cell adhesion
    • positive regulation of cell growth
    • positive regulation of epithelial cell migration
    • positive regulation of epithelial cell proliferation
    • positive regulation of growth
    • positive regulation of hyaluranon cable assembly
    • positive regulation of S phase of mitotic cell cycle
    • response to antibiotic
    • response to reactive oxygen species
    • response to virus
  • performs the following molecular functions:
    • hyaluronan synthase activity
    • hyalurononglucosaminidase activity
    • transcription factor binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoplasmic vesicle
    • extracellular space
    • hyaluranon cable
    • lysosome

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Summary text based on GO annotations supported by structural data

• Hyal1 encodes a protein or proteins that contain the following InterPro domains: Aldolase-type TIM barrel, Epidermal growth factor-like domain, Glycoside hydrolase, superfamily, Hyaluronidase, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hyal1 indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
    • hydrolase activity, acting on glycosyl bonds
  • is located in the following cellular components:
    • extracellular region

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References

1. Jadin L et al. (2008) Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX? FASEB J, 22:4316-26. (PubMed:18772348)
2. Rai SK et al. (2001) Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A, 98:4443-8. (PubMed:11296287)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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