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Gene Ontology Classifications
Symbol
Name
ID
Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
MGI:99779

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Automated description from the Alliance of Genome Resources

Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity and extracellular ligand-gated ion channel activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production; and regulation of protein metabolic process. Localizes to several cellular components, including the axolemma; cholinergic synapse; and integral component of synaptic membrane. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in several structures, including hemolymphoid system; nervous system; paravertebral ganglion; retina; and tongue. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion).



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory