Gene Ontology Classifications

Symbol
Name
ID

Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
MGI:99779

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Automated description from the Alliance of Genome Resources

Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity and extracellular ligand-gated ion channel activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production; and regulation of protein metabolic process. Localizes to several cellular components, including the axolemma; cholinergic synapse; and integral component of synaptic membrane. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in several structures, including hemolymphoid system; nervous system; paravertebral ganglion; retina; and tongue. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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