Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gcgr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gcgr:
  • participates in the following biological processes:
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway
    • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
    • cellular response to glucagon stimulus
    • exocytosis
    • G-protein coupled receptor signaling pathway
    • hormone-mediated signaling pathway
  • performs the following molecular functions:
    • glucagon receptor activity
    • peptide hormone binding
  • is located in the following cellular components:
    • endosome
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Gcgr encodes a protein or proteins that contain the following InterPro domains: GPCR, family 2, extracellular hormone receptor domain, GPCR, family 2, glucagon receptor, GPCR, family 2, glucagon-like peptide-1/glucagon receptor, GPCR, family 2, secretin-like, GPCR, family 2, secretin-like, conserved site, GPCR, family 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gcgr indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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