Automated description from the Alliance of Genome Resources
Predicted to have death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Localizes to the external side of plasma membrane. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); multiple sclerosis; and pancreatic cancer (multiple). Orthologous to human FASLG (Fas ligand).