Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Localizes to external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).