Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fasl. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fasl
  • participates in the following biological processes:
    • apoptotic signaling pathway ^{[1, 2, 6]}
  • is located in the following cellular components:
    • external side of plasma membrane ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fasl
  • participates in the following biological processes:
    • retinal cell programmed cell death ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Fasl
  • participates in the following biological processes:
    • apoptotic process based on interactions with Raf1 ^[5]
    • positive regulation of apoptotic process based on interactions with Nf1, Pik3r1 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fasl:
  • participates in the following biological processes:
    • activation of cysteine-type endopeptidase activity involved in apoptotic process
    • activation of necroptosis by extracellular signals
    • activation of necroptosis of activated-T cells
    • apoptotic signaling pathway
    • cellular chloride ion homeostasis
    • endosomal lumen acidification
    • extrinsic apoptotic signaling pathway via death domain receptors
    • induction of apoptosis
    • inflammatory cell apoptotic process
    • necrotic cell death
    • negative regulation of angiogenesis
    • negative regulation of transcription from RNA polymerase II promoter
    • positive regulation of apoptotic process
    • positive regulation of cell proliferation
    • positive regulation of epidermal growth factor receptor signaling pathway
    • positive regulation of neuron apoptotic process
  • performs the following molecular functions:
    • tumor necrosis factor receptor binding
  • is located in the following cellular components:
    • caveola
    • cytoplasmic membrane-bounded vesicle
    • extracellular space
    • extracellular vesicular exosome
    • membrane raft
    • nucleus
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Fasl encodes a protein or proteins that contain the following InterPro domains: Fas ligand, Tumour necrosis factor, Tumour necrosis factor alpha/beta/c, Tumour necrosis factor, conserved site, Tumour necrosis factor-like, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
    • signal transduction
  • is located in the following cellular components:
    • extracellular region
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fasl indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • cytokine activity
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • extracellular region
    • integral to membrane
    • lysosome
    • membrane
    • plasma membrane

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References

1. Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol, 164:1471-9. (PubMed:15039234)
2. Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun, 327:415-23. (PubMed:15629131)
3. Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity, 25:441-54. (PubMed:16973387)
4. Pequignot MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn, 228:231-8. (PubMed:14517994)
5. Piazzolla D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-{alpha} signaling. J Cell Biol, 171:1013-22. (PubMed:16365167)
6. Takahashi T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76:969-76. (PubMed:7511063)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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