Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ucp1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ucp1
  • participates in the following biological processes:
    • proton transport ^[5]
    • regulation of transcription from RNA polymerase II promoter ^[4]
    • transmembrane transport ^[5]
  • performs the following molecular functions:
    • oxidative phosphorylation uncoupler activity ^[5]
  • is located in the following cellular components:
    • mitochondrial envelope ^[5]
    • mitochondrion ^{[1, 2, 3]}
• The gene product of Ucp1 has been shown to bind to the gene products of Cidea. ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ucp1:
  • participates in the following biological processes:
    • mitochondrial transport
    • proton transport
  • performs the following molecular functions:
    • oxidative phosphorylation uncoupler activity
  • is located in the following cellular components:
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Ucp1 encodes a protein or proteins that contain the following InterPro domains: Mitochondrial brown fat uncoupling protein, Mitochondrial carrier domain, Mitochondrial substrate/solute carrier, indicating that the gene product:
  • is located in the following cellular components:
    • mitochondrial membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ucp1 indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • mitochondrial inner membrane

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References

1. Carmona MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem, 277:21489-98. (PubMed:11940593)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. Yao D et al. (2007) High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem, 282:31038-45. (PubMed:17670746)
5. Zhou Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet, 35:49-56. (PubMed:12910269)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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