Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of cellular metabolic process; and regulation of programmed cell death. Localizes to several cellular components, including chromosome; cytosol; and mitochondrial matrix. Predicted to colocalize with nuclear body and transcription factor TFIID complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study several diseases, including CHARGE syndrome; Li-Fraumeni syndrome; bone cancer (multiple); diffuse large B-cell lymphoma; and endometrial cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).