Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of cellular metabolic process; and regulation of programmed cell death. Localizes to the chromosome; cytoplasm; and nucleus. Predicted to colocalize with the nuclear body and transcription factor TFIID complex. Used to study several diseases, including CHARGE syndrome; Li-Fraumeni syndrome; diffuse large B-cell lymphoma; endometrial cancer; and glioblastoma multiforme. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; carcinoma (multiple); hematologic cancer (multiple); nose disease (multiple); and open-angle glaucoma (multiple). Orthologous to human TP53 (tumor protein p53).