Automated description from the Alliance of Genome Resources
Exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in DNA replication; DNA topological change; and embryonic cleavage. Localizes to the cytoplasm; nucleus; and perikaryon. Predicted to colocalize with the nuclear chromosome. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA topoisomerase I).