Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Timp3. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Timp3
  • participates in the following biological processes:
    • cellular response to organic substance ^[1]
  • is located in the following cellular components:
    • basement membrane ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Timp3:
  • participates in the following biological processes:
    • negative regulation of membrane protein ectodomain proteolysis
    • negative regulation of proteolysis
  • is located in the following cellular components:
    • cytoplasm
    • extracellular matrix

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Summary text based on GO annotations supported by structural data

• Timp3 encodes a protein or proteins that contain the following InterPro domains: Netrin domain, Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, Tissue inhibitor of metalloprotease 3, Tissue inhibitor of metalloproteinases-like, OB-fold, indicating that the gene product:
  • performs the following molecular functions:
    • metalloendopeptidase inhibitor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Timp3 indicates that it:
  • participates in the following biological processes:
    • negative regulation of peptidase activity
  • performs the following molecular functions:
    • enzyme inhibitor activity
    • metal ion binding
    • metalloendopeptidase inhibitor activity
    • peptidase inhibitor activity
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Nishino K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev Growth Differ, 44:35-43. (PubMed:11869290)
2. Yoshiba N et al. (2003) Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development. Dev Dyn, 228:105-12. (PubMed:12950084)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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