Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Involved in several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Localizes to basement membrane and cell surface. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).