Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pde1b. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Pde1b
  • participates in the following biological processes:
    • locomotory behavior ^{[2, 3]}
    • regulation of dopamine metabolic process ^[3]
    • regulation of neurotransmitter levels ^[3]
    • response to amphetamine ^{[1, 3]}
    • serotonin metabolic process ^[3]
    • signal transduction ^[2]
    • visual learning ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Pde1b
  • participates in the following biological processes:
    • response to amphetamine based on interactions with Ppp1r1b ^[1]
    • visual learning based on interactions with Ppp1r1b ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pde1b:
  • participates in the following biological processes:
    • cAMP catabolic process
    • cellular response to granulocyte macrophage colony-stimulating factor stimulus
    • cellular response to macrophage colony-stimulating factor stimulus
    • cGMP catabolic process
  • performs the following molecular functions:
    • 3',5'-cyclic-AMP phosphodiesterase activity
    • calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
    • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
    • cyclic-nucleotide phosphodiesterase activity
  • is located in the following cellular components:
    • cytoplasm
    • neuronal cell body
    • nucleus

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Summary text based on GO annotations supported by structural data

• Pde1b encodes a protein or proteins that contain the following InterPro domains: 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase N-terminal, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, HD/PDEase domain, indicating that the gene product:
  • performs the following molecular functions:
    • 3',5'-cyclic-nucleotide phosphodiesterase activity
    • catalytic activity
    • phosphoric diester hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pde1b indicates that it:
  • performs the following molecular functions:
    • calmodulin binding
    • hydrolase activity
    • metal ion binding
• Pde1b has been associated with the Enzyme Commission numbers: 3.1.4.17, which implies that the gene product:
  • performs the following molecular functions:
    • 3',5'-cyclic-nucleotide phosphodiesterase activity

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References

1. Ehrman LA et al. (2006) Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice. Genes Brain Behav, 5:540-51. (PubMed:17010100)
2. Reed TM et al. (2002) Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J Neurosci, 22:5188-97. (PubMed:12077213)
3. Siuciak JA et al. (2007) Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme. Neuropharmacology, 53:113-24. (PubMed:17559891)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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