Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lipa. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lipa
  • participates in the following biological processes:
    • cell morphogenesis ^[1]
    • cell proliferation ^[1]
    • cytokine production ^[1]
    • homeostasis of number of cells within a tissue ^[1]
    • inflammatory response ^[1]
    • lung development ^[1]
    • tissue remodeling ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lipa:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • sterol metabolic process
  • performs the following molecular functions:
    • lipase activity
    • sterol esterase activity
  • is located in the following cellular components:
    • lysosome

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Summary text based on GO annotations supported by structural data

• Lipa encodes a protein or proteins that contain the following InterPro domains: Alpha/beta hydrolase fold-1, Lipase, eukaryotic, Partial AB-hydrolase lipase domain, indicating that the gene product:
  • participates in the following biological processes:
    • lipid metabolic process
  • performs the following molecular functions:
    • hydrolase activity, acting on ester bonds

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lipa indicates that it:
  • participates in the following biological processes:
    • lipid catabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • hydrolase activity

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References

1. Lian X et al. (2004) Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol, 286:L801-7. (PubMed:14644759)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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