Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Krt17. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Krt17
  • is located in the following cellular components:
    • cell periphery ^[1]
    • cytoplasm ^[3]
• The gene product of Krt17 has been shown to bind to the gene products of Sfn, Tradd. ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Krt17
  • participates in the following biological processes:
    • positive regulation of cell growth ^[2]
    • positive regulation of hair follicle development ^[3]
    • positive regulation of translation ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Krt17
  • participates in the following biological processes:
    • intermediate filament organization based on interactions with Krt6a, Krt6b ^[4]
    • keratinization based on interactions with Krt6a, Krt6b ^[4]
    • morphogenesis of an epithelium based on interactions with Krt6a, Krt6b ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Krt17:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • MHC class II protein binding
    • MHC class II receptor activity

---

Summary text based on GO annotations supported by structural data

• Krt17 encodes a protein or proteins that contain the following InterPro domains: Filament, Intermediate filament protein, Intermediate filament protein, conserved site, Keratin, type I, Prefoldin, indicating that the gene product:
  • performs the following molecular functions:
    • structural molecule activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Krt17 indicates that it:
  • is located in the following cellular components:
    • intermediate filament

---

References

1. Andl T et al. (2006) The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol, 16:1041-9. (PubMed:16682203)
2. Kim S et al. (2006) A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature, 441:362-5. (PubMed:16710422)
3. Tong X et al. (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev, 20:1353-64. (PubMed:16702408)
4. Wong P et al. (2005) Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice. Mol Cell Biol, 25:197-205. (PubMed:15601842)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---