Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcne1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kcne1
  • is located in the following cellular components:
    • apical plasma membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kcne1
  • participates in the following biological processes:
    • epithelial cell maturation ^[2]
    • heart contraction ^[1]
    • regulation of heart rate by cardiac conduction ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcne1:
  • participates in the following biological processes:
    • membrane depolarization
    • positive regulation of potassium ion transmembrane transport
    • potassium ion export
    • potassium ion transmembrane transport
    • protein N-linked glycosylation
    • protein O-linked glycosylation
  • performs the following molecular functions:
    • delayed rectifier potassium channel activity
    • potassium channel regulator activity
    • telethonin binding
    • voltage-gated potassium channel activity
  • is located in the following cellular components:
    • lysosome
    • plasma membrane
    • voltage-gated potassium channel complex
    • Z disc

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Summary text based on GO annotations supported by structural data

• Kcne1 encodes a protein or proteins that contain the following InterPro domains: Potassium channel, voltage-dependent, beta subunit, KCNE, Potassium channel, voltage-dependent, beta subunit, KCNE1, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcne1 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
    • regulation of ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • potassium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Balasubramaniam R et al. (2003) Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol, 552:535-46. (PubMed:14561835)
2. Nicolas M et al. (2001) KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells. Hear Res, 153:132-45. (PubMed:11223304)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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